Re: Update: LDN Trial at Univ. Texas Southwestern

[Guest guest]

I agree that studies are necessary, but I still feel a moral concern about using a placebo on someone with a progressive disease when so much empirical evidence shows that LDN helps. How much damage will occur during the twenty months on the placebo? I would not agree to participate in the study myself.

And no, I don't have any suggestions for a better way, just concerns about this particular method.

----- Original Message -----

From: redtruck99

low dose naltrexone

Sent: Friday, August 27, 2004 10:10 AM

Subject: [low dose naltrexone] Update: LDN Trial at Univ. Texas Southwestern

Just had checkup with my neuro. The LDN study is in the works, but still wending its way thru Internal Review. He described it: 2 groups of 20, placebo double blind for 20 months, then switch groups for another 20 months. And they are going for more than just symptom relief, only enroll long time MS patients with significant deficits, so they can measure recovery improvements like I've had in walking, strength, reflex etc. We will need larger trials than this to prove out LDN, so this is just the beginning.Told him I was solo on LDN since April when I saw him last. He was thrilled with my exam, hugely improved walk, new muscle mass, overall decrease in MS symptoms. He thinks that I am into repair mode now, and asked me to do an MRI to see if I am remylinating old lesions. Will have that in a month or so, and I have 4 recent MRIs from 2002-03 for comparison. I will try to get images I can post at http://LDNers.org He is really curious about this amazing LDN recovery since Feb 2004, because I was in bad shape after 3 years of precipitous decline, walking with cane, even approved for a motorized wheelchair last spring. He said there are very few progressive MS cases that enter recovery mode like I have. I'm not going to post at http://LDNers.org about the UTSW study until they have public info about recruitment, but I think it is OK to update the discussion groups. You can tell your doctors the UTSW trial, if they are reluctant to prescribe Or if they are researchers, I can get my doctors contact info to them.SammyJo