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I started taking 1.75mg LDN about 6 weeks ago. I seem to have

developed severe numbness and/or water retention in my legs and feet.

Has anybody experienced that during the early stages of using LDN?

If so, how did you handle it? I never use medications because I tend

to be super sensitive to almost all. Thus the 1.75mg dosage. Thanks

for any suggestions.

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> I started taking 1.75mg LDN about 6 weeks ago. I seem to have

> developed severe numbness and/or water retention in my legs and feet.

> Has anybody experienced that during the early stages of using LDN?

> If so, how did you handle it? I never use medications because I tend

> to be super sensitive to almost all. Thus the 1.75mg dosage. Thanks

> for any suggestions.

>

===========

,

many of us experienced an increase in a few symptoms when first starting LDN. I

had numb hands for awhile but that went away. Some have found that the numbness

stays with them and I figure it's the LDN that has awakened a damaged area to

only half way to the point you are feeling the damaged area and that feeling

could be numbness.

I've not heard anyone having water retention on LDN. LDN has acted more like a

diuretic for several people.

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--- In low dose naltrexone , " Bren " <TwisterAlley2@w...>

wrote:

> --- In low dose naltrexone , " lncrssk " <linkasis@w...>

wrote:

> > I started taking 1.75mg LDN about 6 weeks ago. I seem to have

> > developed severe numbness and/or water retention in my legs and

feet.

> > Has anybody experienced that during the early stages of using LDN?

> > If so, how did you handle it? I never use medications because I

tend

> > to be super sensitive to almost all. Thus the 1.75mg dosage.

Thanks

> > for any suggestions.

> >

>

> ===========

>

> ,

many of us experienced an increase in a few symptoms when first

starting LDN. I had numb hands for awhile but that went away. Some

have found that the numbness stays with them and I figure it's the

LDN that has awakened a damaged area to only half way to the point

you are feeling the damaged area and that feeling could be numbness.

>

> I've not heard anyone having water retention on LDN. LDN has acted

more like a diuretic for several people.

>

>

Thank you so much, . Your answer is very encouraging. Every day

I debate taking the LDN that night. I wondered about whether my

symptoms could indicate something positive happening, as with using

alternative medicine. Best to you.

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  • 2 weeks later...

,

Don't get discouraged! As you can tell, it's different for everyone. You have gotten several different viewpoints. Start trying something different than what you did the first two nights. Like I said before, hang in there! Be tough!

Marcie

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Hi,

Isn't it wonderful how you received so many responses to your post? I love it.

I found it very helpful to me as I am newly diagnosed and 6 days into LDN. I

had trouble sleeping the first night but that was it now I sleep great.

I was very nervous about it at first but not anymore. I would give it some time

AND don't overlook the other things you can be doing for your MS. For

instance the doctor working with me wants to check all the metal toxin levels

in my body because they are damaging to the central nervous system. He

also told me that dairy is often a culprit of ms exacerbations. And that's just

for

starters. I think any disease has to be dealt with on all levels.

I believe the LDN needed to be in place tho to give proper support to my body

but the buck doesn't stop there.

I agree with others - try perhaps a different time or give it more time. Each

person will have their own response to the drug just as each person has their

own form of MS.

Stay connected. Reaching out is the best thing to do until you get stablized.

All the best to you,

Alice

>

> Hi-

> I took my first two 3 mg doses at about 10 PM for two successive

> nights and I was not able to sleep at all those nights. I have not

> taken a dose since as it leaves me so exhausted the next day that I

> cannot function. BTW I have SPMS, so fatigue is already an issue.

> Can anyone offer any advice about this problem?

>

> Thanks,

>

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,

I experienced a similar problem when I started LDN. It passed in a week or so.

Regards,

Tom

----- Original Message -----

From: marciemjm@...

low dose naltrexone

Sent: Wednesday, October 13, 2004 7:02 PM

Subject: Re: [low dose naltrexone] New User Questions

In a message dated 10/13/2004 5:46:15 PM Central Daylight Time, abolo@... writes:

Hi- I took my first two 3 mg doses at about 10 PM for two successive nights and I was not able to sleep at all those nights. I have not taken a dose since as it leaves me so exhausted the next day that I cannot function. BTW I have SPMS, so fatigue is already an issue. Can anyone offer any advice about this problem? Thanks, , Surely you were aware that this is a possible side effect that usually doesn't last more than 3 - 4 weeks, if that long. Either stick it out or give up after 2 nights. It's strictly up to you. Are you still mobile? If so, believe me, it can get much worse. I would hate to see you throw in the towel so soon only to continue progressing. I didn't sleep for nearly one month after starting LDN. But since I can't stand, balance, or walk at all, my life pretty much consists of doing very little anyway. My bladder issues were much improved immediately, and after the first month I sleep very well. I do believe my progression has stopped. I was about one step away from some type of assisted living arrangement. I know that different people's tolerance to pain varies. Also, some people just handle situations differently. Hang in there! Marcie

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---

I am SPMS and I have been on LDN for almost a year now. The first 3-4

weeks I went through many changes, but you should be used to changes

just by the fact of having MS. (most of which are negative)Stick with

it, you will be glad you did! I sure am!

Steve

In low dose naltrexone , " Bayuk " <tbayuk@c...>

wrote:

> ,

> I experienced a similar problem when I started LDN. It passed in a

week or so.

> Regards,

> Tom

>

> ----- Original Message -----

> From: marciemjm@a...

> low dose naltrexone

> Sent: Wednesday, October 13, 2004 7:02 PM

> Subject: Re: [low dose naltrexone] New User Questions

>

>

> In a message dated 10/13/2004 5:46:15 PM Central Daylight Time,

abolo@d... writes:

>

>

>

> Hi-

> I took my first two 3 mg doses at about 10 PM for two

successive

> nights and I was not able to sleep at all those nights. I have

not

> taken a dose since as it leaves me so exhausted the next day

that I

> cannot function. BTW I have SPMS, so fatigue is already an

issue.

> Can anyone offer any advice about this problem?

>

> Thanks,

>

>

>

>

>

> ,

>

> Surely you were aware that this is a possible side effect that

usually doesn't last more than 3 - 4 weeks, if that long. Either

stick it out or give up after 2 nights. It's strictly up to you.

Are you still mobile? If so, believe me, it can get much worse. I

would hate to see you throw in the towel so soon only to continue

progressing. I didn't sleep for nearly one month after starting

LDN. But since I can't stand, balance, or walk at all, my life

pretty much consists of doing very little anyway. My bladder issues

were much improved immediately, and after the first month I sleep

very well. I do believe my progression has stopped. I was about one

step away from some type of assisted living arrangement.

>

> I know that different people's tolerance to pain varies. Also,

some people just handle situations differently. Hang in there!

>

> Marcie

>

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,

I'm sure you'll be getting lots of reply on this question. Believe me I can

relate, I don't mean to scare you but I took ldn for 6 months before I

started getting 5 to 6 hours. The first few weeks are the worst, if your

against sleeping pills, go to your health food store and buy something more

natural. It's worth the work, it's the best treatment there is for MS!

Presently I sleep like a baby and I've been taking 4.5mg. Best of luck to

you, hang in there!

-----Original Message-----

From: abolo@... [mailto:abolo@...]

Sent: Wednesday, October 13, 2004 6:43 PM

low dose naltrexone

Subject: [low dose naltrexone] New User Questions

Hi-

I took my first two 3 mg doses at about 10 PM for two successive nights and

I was not able to sleep at all those nights. I have not taken a dose since

as it leaves me so exhausted the next day that I cannot function. BTW I have

SPMS, so fatigue is already an issue.

Can anyone offer any advice about this problem?

Thanks,

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In a message dated 10/14/2004 8:57:07 AM Central Daylight Time, bob <chiefman596@... writes:

Only problem that's concerning me write now is, I started the LDN write after a dose of solumedrol, and was feeling 100% normal with all sensation in my feet back to normal. But in the last week I feel my feet once again going numb again. Does this seem like a normal thing to most people taking LDN at first.

I've just started 4.5 mg after a month of 3.0 mg. I had the same thing happen. Improved stiffness and energy for first couple of weeks, but began to notice this eroding in last 2 weeks. More leg stiffness and what I call my ankle/lower leg just "seizing up, especially in the evening." I've been on 4.5 for a couple of days now and this has improved and I'm back to where I was in first 2 weeks of LDN. No side effects at 4.5 so I'll probably just stay here unless this happens again.

I've decided the 'warm' feeling up my r. leg is the numbness going away a little at a time. A very tamped down version of your leg waking up after circulation has been cut off.

and , I take the LDN right before I fall asleep--whatever time that is. I've had times when I felt a bit speedy during the day, even, but that has toned down and now I just feel--well--normal! normal energy....normal getting tired after a full day.

I don't always get to bed at the same time, and I'm usually really sleepy by the time I do. I have a bottle of water right by my bed, and take the LDN, slide down and go right to sleep. Someone else here suggested that and it really works for me. I woke up early for a few nights at first, and couldn't get back to sleep, but that has stopped.

Daphne

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