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New Discussion: how rational are COX-2 inhibitors?

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Hello everybody I welcome you all for the discussion on the topic "how rational are COX-2 inhibitors?".

Definition

-2 inhibitors are non-steroidal

anti-inflammatory drugs (NSAIDs) which selectively inhibit

cyclooxygenase-2. The traditional NSAIDs inhibit both cyclooxygenase 1 and 2

(-1 and -2). However, while -2 is associated with inflammation and pain, -1 maintains the integrity of

the gastric mucosa, mediates normal platelet function, and regulates renal

blood flow.Dr. K. JaiswalLecturer, Dept of Pharmacology.GMC, Nagpur.

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