Naltrexone, low or normal dose? Please do LDN!

[Guest guest]

Hello Dear LDNer,

I have read all the messages here and I am gratefull to participate

on Your Experiencies with LDN.

However, I also read the messages of Dr. Fuhrman.

Instead of trying to see the backgrounds of dr. Bihari´s Theory on

LDN, dr Fuhrman proposes a fully different workingprincip of

opioidantagonists. His theory is, the blocking of all the opioid

receptors, including a yet not known, proposed receptor, must be

immune suppressive. However, that is definitivly not true.

The problem ist, there are a lot of experimental study´s that have

shown contradictory results. The usual normal dose of Naltrexone

boosts Your Immunesystem wich means, Your MS may worsen. Therefore I

must warn You for taking higher doses as 6 mg a day.

You can find a very good E-Book in the www with a very good capitle

about opioids and the immunesystem by Sacerdote and several other

international known investegators at:

http://www.ncbi.nlm.nih.gov/books/bv.fcgi?

call=bv.View..ShowSection & rid=eurekah.chapter.10978

It is a very medical publication but hard to read for people without

a medical education..

Dr. Bihari says, LDN works, while it puts up the level of natrurally

Endorphins in the immunecells. That is correct. All the knowm

Antagonists have a biphasic workingprincip. In very low doses they

increase the level of Endorphins. And that is what is working

immunesuppressive. Beta-interferons like avonex, betaseron and rebif

also increase the intracellular level of the Endorphins and the

scientific world now believes, the Immunsystem is being regulated not

only by cyokines but also by opioids and they are a counterpart of

eachother. If the cytokinesystem makes an up regulation, the

opioidsystem will downregulate it again, and vv.

In MS, there is an overactivity of proinflammatory cytokines, wich

induces an upregulation of the immune cells. Naltrexone in very low

doses modulates the opioid receptors on immunecells and attenuates

the effect of the naturally endorphins. The Immuneresponse is

being " normalised " .

After passing a " Point of no return " increasing the dose of

Naltrexone suddenly blocks these effects and intracellular levels of

endorphins will decrease again. This causes an Upregulation of the

Immunecells as well.

Taken at higher doses than 10 mg, Naltrexone may cause a worsening of

diseases like MS, Crohn´s disease, colitis, psoriasis and rheumatoid

arthritis. It also may have the effect, that some kinds of cancer may

worsen unther higher doses of Naltrexone,

Therefore: please stay at your doses of 3-4,5 mg once daily.

Theoreticly this works, but we need to do a lot of research on LDN

and find out how good it really is. If it really is as good as the

interferons are, LDN must be introduced in our therapeutic repertoire

for MS.

Preliminary results of the survey done by (LDN research Trust)

and Dr. Coles in the UK ar very exiting! Please see for the

results: http://ldners.org/Reports/LDN_Survey1_Analysis.pdf

To me: I am a german neurologist and I am very interested to read

Your experiencies here and am very interested on more scientific

information about LDN. I would be gratefull if could me help me in

the last point.