Re: the most important article about opiatreceptor and immunsystem

[Guest guest]

Dear Dr. Fuhrmann,

Thank you so much for becoming involved with this board. It is

wonderfull to have a doctor who is willing to respond to some of our

questions.

If my neurologist is intersted, would you mind if she sent you an

email?

Pam

[Guest guest]

Dr. Fuhrmann perhaps you can tell us more about you and MS, what sort of symptoms did you have prior taking Naltrexone, how long do you have MS, what symptoms do you have now taking Naltrexone, and how long are you taking Naltrexone? Are there days when you do not take Naltrexone?

Thank you

***Zora*** San Trinidad, West Indies ****** ***

[Guest guest]

> 1. Re: the most important article about opiatreceptor and

> immunsystem

> From: " pamridge49 " <prsklak@...>

>

this is the article:

http://tinylink.com/?9eRwRnTSkJ

Is the goal of the antagonist to be immunosuppressive?

so endorphin counts also would go way down?

this doesn't go with my thinking the last time I did some reading (a

few months back now)

where MS is caused by oligodendracyte apoptosis and the LDN is blocking

that programmed

cell death.

but you're the doc!

[Guest guest]

Well I started taking LDN about month ago, I think I get enough benefit from it this way, if I take higher dosage like you I am opening myself to another danger...cancer...I think I have plenty to deal with as it is, I am not doubting you, you might be right, but neither LDN nor Naltrexone are cures and taking that amount for long period of time might be very detrimental to your health....

As it is al this is still anecdotal, we are only now making some progress with some doctors, perhaps you can try to speak to Dr. Behari directly, he might listen to you.

Zora

Hi Zora!

I have answerde all your questions in english on my forum,take a look,please.The forum is better,because I have about 5000 hits per day and more people can read it.

Thanks Manfred

http://f27.parsimony.net/forum67820/index.htm

----- Original Message -----

From: Zora

low dose naltrexone

Sent: Sunday, October 03, 2004 3:40 PM

Subject: Re: [low dose naltrexone] the most important article about opiatreceptor and immunsystem

Dr. Fuhrmann perhaps you can tell us more about you and MS, what sort of symptoms did you have prior taking Naltrexone, how long do you have MS, what symptoms do you have now taking Naltrexone, and how long are you taking Naltrexone? Are there days when you do not take Naltrexone?

Thank you

***Zora*** San Trinidad, West Indies ****** ***

[Guest guest]

Dr Furmann, you have not addressed the side effect that causes "junkies" to stop using Naltrexone, the depression. For people with MS depression is an extremely serious issue. Do you find that your moods stay upbeat on the higher dose? Do you experience a sense of well being? One of the effects of LDN has been an improved sense of well being, another side effect for many of us has been muscle stiffness. What happens with the muscle stiffness at higher doses?

How many people are using Naltrexone for MS at the 50 mg dosage?

Thanks for your input.

----- Original Message -----

From: Dr.Fuhrmann

low dose naltrexone

Sent: Sunday, October 03, 2004 9:49 AM

Subject: Re: [low dose naltrexone] the most important article about opiatreceptor and immunsystem

Hi Zora!

You are not right.The danger of cancer is only theoretically speculation,because the OGF(opiod growth factor) is blocked,which stopps growing cancer,but many junkies take Nemexin without getting cancer.Maybe you dont need OGF,if you dont have cancer cells.Naltrex at 50 mg is without serios side effects even if you take it longer,it is a very harmless drug.If 50 mg works better,why you dont even try it?I would also take the risk of getting cancer,as to be undertreated.If Naltrex really can produce cancer it can also produce it at low dose.If Dr.Bihari wants to speak with me,he can write in my forum,give him the adress,tell him about the new found opiat receptors,which block the immun system.

: J Neuroimmunol. 2004 Feb;147(1-2):121-2.

Related Articles,

Links

Antibody response and allogeneic mixed lymphocyte reaction in mu-, delta-, and kappa-opioid receptor knockout mice.Gaveriaux-Ruff C, Simonin F, Filliol D, Kieffer B.Department of Neurobiology, Institute de Genetique et de Biologie Moleculaire et Cellular, BP 163, CU de Strasborg, 67404 Illkirch cedex, France. gaveriau@...The implication of opioid receptors in immune response has been studied using mu-, delta- and kappa-opioid receptor knockout mice. The mutant animals were compared to their wild-type (WT) counterparts for antibody (Ab) response to the prototype Ag keyhole limpet hemocyanin (KLH). Kappa-receptor deficient mice displayed higher Ab titers for either total Ig, IgM, IgG1 or IgG2a isotypes, whereas mu and delta animals behaved as wild-type mice. Therefore, endogenous kappa-receptor activation would tonically inhibit Ab response. Opioid receptor deficient mice were also used to investigate the immunosuppressive action of naltrindole, a delta-opioid receptor antagonist, shown earlier to inhibit graft rejection and the allogeneic mixed lymphocyte reaction (MLR) in vitro. Naltrindole and two related compounds inhibited MLR performed with lymphocytes from wild-type and delta-opioid receptor knockout mice. These compounds also suppressed MLR assayed with cells from triple mu/delta/kappa-opioid receptor mutants. We therefore demonstrate that naltrindole immunosuppressive activity is not mediated by any of the three mu-, delta- or kappa-opioid receptors, but by a target which remains to be discovered.

----- Original Message -----

From: Zora

low dose naltrexone

Sent: Sunday, October 03, 2004 6:17 PM

Subject: Re: [low dose naltrexone] the most important article about opiatreceptor and immunsystem

Well I started taking LDN about month ago, I think I get enough benefit from it this way, if I take higher dosage like you I am opening myself to another danger...cancer...I think I have plenty to deal with as it is, I am not doubting you, you might be right, but neither LDN nor Naltrexone are cures and taking that amount for long period of time might be very detrimental to your health....

As it is al this is still anecdotal, we are only now making some progress with some doctors, perhaps you can try to speak to Dr. Behari directly, he might listen to you.

Zora

Hi Zora!

I have answerde all your questions in english on my forum,take a look,please.The forum is better,because I have about 5000 hits per day and more people can read it.

Thanks Manfred

http://f27.parsimony.net/forum67820/index.htm

----- Original Message -----

From: Zora

low dose naltrexone

Sent: Sunday, October 03, 2004 3:40 PM

Subject: Re: [low dose naltrexone] the most important article about opiatreceptor and immunsystem

Dr. Fuhrmann perhaps you can tell us more about you and MS, what sort of symptoms did you have prior taking Naltrexone, how long do you have MS, what symptoms do you have now taking Naltrexone, and how long are you taking Naltrexone? Are there days when you do not take Naltrexone?

Thank you

***Zora*** San Trinidad, West Indies ****** ***

[Guest guest]

another side effect of Naltrexone is stomach cramps

Zora

Dr Furmann, you have not addressed the side effect that causes "junkies" to stop using Naltrexone, the depression. For people with MS depression is an extremely serious issue. Do you find that your moods stay upbeat on the higher dose? Do you experience a sense of well being? One of the effects of LDN has been an improved sense of well being, another side effect for many of us has been muscle stiffness. What happens with the muscle stiffness at higher doses?

How many people are using Naltrexone for MS at the 50 mg dosage?

Thanks for your input.

----- Original Message -----

From: Dr.Fuhrmann

low dose naltrexone

Sent: Sunday, October 03, 2004 9:49 AM

Subject: Re: [low dose naltrexone] the most important article about opiatreceptor and immunsystem

Hi Zora!

You are not right.The danger of cancer is only theoretically speculation,because the OGF(opiod growth factor) is blocked,which stopps growing cancer,but many junkies take Nemexin without getting cancer.Maybe you dont need OGF,if you dont have cancer cells.Naltrex at 50 mg is without serios side effects even if you take it longer,it is a very harmless drug.If 50 mg works better,why you dont even try it?I would also take the risk of getting cancer,as to be undertreated.If Naltrex really can produce cancer it can also produce it at low dose.If Dr.Bihari wants to speak with me,he can write in my forum,give him the adress,tell him about the new found opiat receptors,which block the immun system.

: J Neuroimmunol. 2004 Feb;147(1-2):121-2.

Related Articles,

Links

Antibody response and allogeneic mixed lymphocyte reaction in mu-, delta-, and kappa-opioid receptor knockout mice.Gaveriaux-Ruff C, Simonin F, Filliol D, Kieffer B.Department of Neurobiology, Institute de Genetique et de Biologie Moleculaire et Cellular, BP 163, CU de Strasborg, 67404 Illkirch cedex, France. gaveriau@...The implication of opioid receptors in immune response has been studied using mu-, delta- and kappa-opioid receptor knockout mice. The mutant animals were compared to their wild-type (WT) counterparts for antibody (Ab) response to the prototype Ag keyhole limpet hemocyanin (KLH). Kappa-receptor deficient mice displayed higher Ab titers for either total Ig, IgM, IgG1 or IgG2a isotypes, whereas mu and delta animals behaved as wild-type mice. Therefore, endogenous kappa-receptor activation would tonically inhibit Ab response. Opioid receptor deficient mice were also used to investigate the immunosuppressive action of naltrindole, a delta-opioid receptor antagonist, shown earlier to inhibit graft rejection and the allogeneic mixed lymphocyte reaction (MLR) in vitro. Naltrindole and two related compounds inhibited MLR performed with lymphocytes from wild-type and delta-opioid receptor knockout mice. These compounds also suppressed MLR assayed with cells from triple mu/delta/kappa-opioid receptor mutants. We therefore demonstrate that naltrindole immunosuppressive activity is not mediated by any of the three mu-, delta- or kappa-opioid receptors, but by a target which remains to be discovered.

----- Original Message -----

From: Zora

low dose naltrexone

Sent: Sunday, October 03, 2004 6:17 PM

Subject: Re: [low dose naltrexone] the most important article about opiatreceptor and immunsystem

Well I started taking LDN about month ago, I think I get enough benefit from it this way, if I take higher dosage like you I am opening myself to another danger...cancer...I think I have plenty to deal with as it is, I am not doubting you, you might be right, but neither LDN nor Naltrexone are cures and taking that amount for long period of time might be very detrimental to your health....

As it is al this is still anecdotal, we are only now making some progress with some doctors, perhaps you can try to speak to Dr. Behari directly, he might listen to you.

Zora

Hi Zora!

I have answerde all your questions in english on my forum,take a look,please.The forum is better,because I have about 5000 hits per day and more people can read it.

Thanks Manfred

http://f27.parsimony.net/forum67820/index.htm

----- Original Message -----

From: Zora

low dose naltrexone

Sent: Sunday, October 03, 2004 3:40 PM

Subject: Re: [low dose naltrexone] the most important article about opiatreceptor and immunsystem

Dr. Fuhrmann perhaps you can tell us more about you and MS, what sort of symptoms did you have prior taking Naltrexone, how long do you have MS, what symptoms do you have now taking Naltrexone, and how long are you taking Naltrexone? Are there days when you do not take Naltrexone?

Thank you

***Zora*** San Trinidad, West Indies ****** ***

[Guest guest]

Again, thank you for your response. I understand that 50mg is not a high dose of this medication, nor do I have any real concerns regarding its safety. I am most concerned about the depression seen in addicts (but perhaps that is due to physiological changes caused by the addiction) and the muscle stiffness and spasms we tend to experience on the low dose. Your information is very interesting, please continue to participate in our group.

JT

----- Original Message -----

From: Dr.Fuhrmann

low dose naltrexone

Sent: Sunday, October 03, 2004 10:21 AM

Subject: Re: [low dose naltrexone] the most important article about opiatreceptor and immunsystem

The dosis is not so high,test of the toxicity showed,that 800 mg are without a danger.You cannot do more as to block your receptors.I think Naltrex is an antidepressive agent,at least it speeds you up.You have more of this positive effect if you take a higher dose.I feel extremly well.I have some patients,who lay at bed all the day since 3-4 years.On the third day of 50 mg Naltrex they did not need any muscle relaxants anymore.I am just starting giving patients Nemexin 50 mg,the pharmacy have not had it and they have to wait,the number soon grows.There are 5 people till yet. All are satiesfied.Manfred

----- Original Message -----k

From:

low dose naltrexone

Sent: Sunday, October 03, 2004 6:55 PM

Subject: Re: [low dose naltrexone] the most important article about opiatreceptor and immunsystem

Dr Furmann, you have not addressed the side effect that causes "junkies" to stop using Naltrexone, the depression. For people with MS depression is an extremely serious issue. Do you find that your moods stay upbeat on the higher dose? Do you experience a sense of well being? One of the effects of LDN has been an improved sense of well being, another side effect for many of us has been muscle stiffness. What happens with the muscle stiffness at higher doses?

How many people are using Naltrexone for MS at the 50 mg dosage?

Thanks for your input.

----- Original Message -----

From: Dr.Fuhrmann

low dose naltrexone

Sent: Sunday, October 03, 2004 9:49 AM

Subject: Re: [low dose naltrexone] the most important article about opiatreceptor and immunsystem

Hi Zora!

You are not right.The danger of cancer is only theoretically speculation,because the OGF(opiod growth factor) is blocked,which stopps growing cancer,but many junkies take Nemexin without getting cancer.Maybe you dont need OGF,if you dont have cancer cells.Naltrex at 50 mg is without serios side effects even if you take it longer,it is a very harmless drug.If 50 mg works better,why you dont even try it?I would also take the risk of getting cancer,as to be undertreated.If Naltrex really can produce cancer it can also produce it at low dose.If Dr.Bihari wants to speak with me,he can write in my forum,give him the adress,tell him about the new found opiat receptors,which block the immun system.

: J Neuroimmunol. 2004 Feb;147(1-2):121-2.

Related Articles,

Links

Antibody response and allogeneic mixed lymphocyte reaction in mu-, delta-, and kappa-opioid receptor knockout mice.Gaveriaux-Ruff C, Simonin F, Filliol D, Kieffer B.Department of Neurobiology, Institute de Genetique et de Biologie Moleculaire et Cellular, BP 163, CU de Strasborg, 67404 Illkirch cedex, France. gaveriau@...The implication of opioid receptors in immune response has been studied using mu-, delta- and kappa-opioid receptor knockout mice. The mutant animals were compared to their wild-type (WT) counterparts for antibody (Ab) response to the prototype Ag keyhole limpet hemocyanin (KLH). Kappa-receptor deficient mice displayed higher Ab titers for either total Ig, IgM, IgG1 or IgG2a isotypes, whereas mu and delta animals behaved as wild-type mice. Therefore, endogenous kappa-receptor activation would tonically inhibit Ab response. Opioid receptor deficient mice were also used to investigate the immunosuppressive action of naltrindole, a delta-opioid receptor antagonist, shown earlier to inhibit graft rejection and the allogeneic mixed lymphocyte reaction (MLR) in vitro. Naltrindole and two related compounds inhibited MLR performed with lymphocytes from wild-type and delta-opioid receptor knockout mice. These compounds also suppressed MLR assayed with cells from triple mu/delta/kappa-opioid receptor mutants. We therefore demonstrate that naltrindole immunosuppressive activity is not mediated by any of the three mu-, delta- or kappa-opioid receptors, but by a target which remains to be discovered.

----- Original Message -----

From: Zora

low dose naltrexone

Sent: Sunday, October 03, 2004 6:17 PM

Subject: Re: [low dose naltrexone] the most important article about opiatreceptor and immunsystem

Well I started taking LDN about month ago, I think I get enough benefit from it this way, if I take higher dosage like you I am opening myself to another danger...cancer...I think I have plenty to deal with as it is, I am not doubting you, you might be right, but neither LDN nor Naltrexone are cures and taking that amount for long period of time might be very detrimental to your health....

As it is al this is still anecdotal, we are only now making some progress with some doctors, perhaps you can try to speak to Dr. Behari directly, he might listen to you.

Zora

Hi Zora!

I have answerde all your questions in english on my forum,take a look,please.The forum is better,because I have about 5000 hits per day and more people can read it.

Thanks Manfred

http://f27.parsimony.net/forum67820/index.htm

----- Original Message -----

From: Zora

low dose naltrexone

Sent: Sunday, October 03, 2004 3:40 PM

Subject: Re: [low dose naltrexone] the most important article about opiatreceptor and immunsystem

Dr. Fuhrmann perhaps you can tell us more about you and MS, what sort of symptoms did you have prior taking Naltrexone, how long do you have MS, what symptoms do you have now taking Naltrexone, and how long are you taking Naltrexone? Are there days when you do not take Naltrexone?

Thank you

***Zora*** San Trinidad, West Indies ****** ***

[Guest guest]

I am taking 3.0 MG, I tried 4.5 MG for 38 days and the higher dose was worse for me.

Thanks for your efforts, but it seems to me more like an attempted monkey wrench and plant from the CRAB companies than valid information.

I'm using 3.0 MG for 536 days now (except for 301-359 at 4.5 MG) and am doing GREAT. I see no need to mess with a good thing.

----- Original Message -----

From: Dr.Fuhrmann

low dose naltrexone

Sent: Sunday, October 03, 2004 13:21

Subject: Re: [low dose naltrexone] the most important article about opiatreceptor and immunsystem

The dosis is not so high,test of the toxicity showed,that 800 mg are without a danger.You cannot do more as to block your receptors.I think Naltrex is an antidepressive agent,at least it speeds you up.You have more of this positive effect if you take a higher dose.I feel extremly well.I have some patients,who lay at bed all the day since 3-4 years.On the third day of 50 mg Naltrex they did not need any muscle relaxants anymore.I am just starting giving patients Nemexin 50 mg,the pharmacy have not had it and they have to wait,the number soon grows.There are 5 people till yet. All are satiesfied.Manfred

[Guest guest]

We had someone come here who got Naltrexone for their father or some relative, but they got the 50 MG tabs and started taking them nightly. After he was getting violently ill in response, they came here (or maybe it was another LDN group) and we told them L-D-n, 3.0 or 4.5 MG, NOT 50 MG.

Someone else here was taking 25 MG but they dropped down to the LDN size, I believe they also did much better with their MS at the lower dose.

Something just doesn't seem right. I don't think this is beneficial to any of us, especially with a language barrier.

----- Original Message -----

From:

low dose naltrexone

Sent: Sunday, October 03, 2004 13:30

Subject: Re: [low dose naltrexone] the most important article about opiatreceptor and immunsystem

Again, thank you for your response. I understand that 50mg is not a high dose of this medication, nor do I have any real concerns regarding its safety. I am most concerned about the depression seen in addicts (but perhaps that is due to physiological changes caused by the addiction) and the muscle stiffness and spasms we tend to experience on the low dose. Your information is very interesting, please continue to participate in our group.

JT

----- Original Message -----

From: Dr.Fuhrmann

low dose naltrexone

Sent: Sunday, October 03, 2004 10:21 AM

Subject: Re: [low dose naltrexone] the most important article about opiatreceptor and immunsystem

The dosis is not so high,test of the toxicity showed,that 800 mg are without a danger.You cannot do more as to block your receptors.I think Naltrex is an antidepressive agent,at least it speeds you up.You have more of this positive effect if you take a higher dose.I feel extremly well.I have some patients,who lay at bed all the day since 3-4 years.On the third day of 50 mg Naltrex they did not need any muscle relaxants anymore.I am just starting giving patients Nemexin 50 mg,the pharmacy have not had it and they have to wait,the number soon grows.There are 5 people till yet. All are satiesfied.Manfred