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Jeff el sent me this very important info:

Regards,

Tom

September 23, 2004

Antioxidant effects of ferulic acid elucidated

By NewsRx.com

The antioxidant effects of ferulic acid have been elucidated.

"Although an antioxidant mechanism has been involved in the beneficial effects of ferulic acid in human diseases, there are few reports on the antioxidant properties of this compound in isolated membranes and intact cells," scientists in Italy explained.

To rectify this, S. Trombino and colleagues at the University of the Sacred Heart in Rome "evaluated the ability of ferulic acid in inhibiting lipid peroxidation in rat liver microsomal membranes and reactive oxygen species production in NIH-3T3 fibroblasts, induced by both tert-BOOH and AAPH."

"We also compared its antioxidant efficiency with that of other antioxidants, such as alpha-tocopherol, beta-carotene, and ascorbic acid, added alone or in combination," according to the report. "Ferulic acid acted as a potent antioxidant in our models, being more effective in protecting from tert-BOOH than from AAPH."

"Moreover, the compound was the most effective among the antioxidants tested," published data showed.

"Synergistic interactions were observed when the compound was used in combination with the other antioxidants, suggesting that they can cooperate in preserving physiological integrity of cells exposed to free radicals," the researchers concluded.

Trombino and coauthors published their findings in the Journal of Agricultural and Food Chemistry (Antioxidant effect of ferulic acid in isolated membranes and intact cells: Synergistic interactions with alpha-tocopherol, beta-carotene, and ascorbic acid. J Agr Food Chem, 2004;52(8):2411-2420).

Additional information can be obtained by contacting P. Palozza, University of the Sacred Heart, Institute of General Pathology, Largo F. Vito 1, I-00168 Rome, Italy.

The publisher of the Journal of Agricultural and Food Chemistry can be contacted at: American Chemical Society, 1155 16th St. NW, Washington, DC 20036 USA.

The information in this article comes under the major subject areas of Antioxidants, Biotechnology, Cell Biology, Endocrinology and Lipid Studies. This article was prepared by Biotech Week editors from staff and other reports. Copyright 2004, Biotech Week via NewsRx.com & NewsRx.net.

To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com.

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