Re: Help please with interpreting test results

[Guest guest]

Sheila,

You wrote:

>

> But was not on any thyroid hormone replacement when his TSH and

> FT£ were high in two of his previous tests. Also, he is only taking 50

> mcgs T4.

If the pituitary is over producing TSH, that tells the thyroid to keep

trying. The problem is that the resulting high FT3 fails to bring the

TSH back down, so you get both going up. High TSH also stimulates T4/T3

conversion, so you end up with high T3/FT3, high TSH, and low/normal T4.

OTOH, hyperT from this cause is less common than Cushing's.

Chuck

[Guest guest]

Hi Mo, I did get my reverse T3 Done with my last set of tests

(reverse T3 O.44 ref 0.14-0.54) to try to find out what is going on,

my adrenals were at stage 5 back in April and although I have tried

liquorice root and B12 I don't think it has helped, maybe HC is the

answer. I prefer your scenario to Chuck's, but only time will tell

which is right.

Best wishes

>

> High cortisol can block conversion of T4 into T3 and low cortisol

> prevents uptake into the cells.

> Have you had your RT3 checked ? I am not 100% on this I have

to

> say but iot may be implicated in high FT3 I think......

>

> Mo

>

>

> >

[Guest guest]

On the face of it , I would have thought you would need

something a lot stronger like hydrocortisone, with an ASI like that.

As to the possible RT3 dominance as being another factor in the high

FT3.

Your RT3 result looks high but I believe it is the ratio between this

and your FT3 which is important. If the ratio of T3 to Reverse T3 is

less than ten to one along with clinical symptoms, then this

indicates an issue with RT3.

Mo

>

> Hi Mo, I did get my reverse T3 Done with my last set of tests

> (reverse T3 O.44 ref 0.14-0.54) to try to find out what is going

on,

> my adrenals were at stage 5 back in April and although I have tried

> liquorice root and B12 I don't think it has helped, maybe HC is the

> answer. I prefer your scenario to Chuck's, but only time will tell

> which is right.

>

> Best wishes

>

>

> >

> > High cortisol can block conversion of T4 into T3 and low cortisol

> > prevents uptake into the cells.

> > Have you had your RT3 checked ? I am not 100% on this I have

> to

> > say but iot may be implicated in high FT3 I think......

> >

> > Mo

> >

> >

> > >

>

[Guest guest]

ps. and, of course, if there is an RT3 issue , then you would

need to come off any thyroid med with T4 in it AND ensure your own

TSH is suppressed so that your body does not add in any more of your

own T4 to feed the process.

Mo

>

> On the face of it , I would have thought you would need

> something a lot stronger like hydrocortisone, with an ASI like that.

> As to the possible RT3 dominance as being another factor in the

high

> FT3.

> Your RT3 result looks high but I believe it is the ratio between

this

> and your FT3 which is important. If the ratio of T3 to Reverse T3

is

> less than ten to one along with clinical symptoms, then this

> indicates an issue with RT3.

>

> Mo

>

> >

> > Hi Mo, I did get my reverse T3 Done with my last set of tests

> > (reverse T3 O.44 ref 0.14-0.54) to try to find out what is going

> on,

> > my adrenals were at stage 5 back in April and although I have

tried

> > liquorice root and B12 I don't think it has helped, maybe HC is

the

> > answer. I prefer your scenario to Chuck's, but only time will

tell

> > which is right.

> >

> > Best wishes

> >

> >

> > >

> > > High cortisol can block conversion of T4 into T3 and low

cortisol

> > > prevents uptake into the cells.

> > > Have you had your RT3 checked ? I am not 100% on this I

have

> > to

> > > say but iot may be implicated in high FT3 I think......

> > >

> > > Mo

> > >

> > >

> > > >

> >

>

[Guest guest]

Hi

... perhaps I should have said 'look at the Supplementary Data ~ Tables

1b and 1d' in Panicker's paper, and left it at that....

then I wouldn't have made a mess of transcribing it :-)

best wishes

Bob

> Hi

> the line in the Supplementary data:-

> This SNP ~ rs2235544

[Guest guest]

This is Dr Lowe's take on Conversion of T4 to T3 and Reverse-T3: http://www.drlowe.com/QandA/askdrlowe/thymetab.htm

Luv - Sheila

ps. and, of course, if there is an RT3 issue , then you would need to come off any thyroid med with T4 in it AND ensure your own TSH is suppressed so that your body does not add in any more of your own T4 to feed the process.Mo

..

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[Guest guest]

I don't understand this bit:

" Also, if impaired conversion was the source of the problem in my

fibromyalgia patients, they would respond to a normal physiologic

dosage of T3. However, most euthyroid fibromyalgia patients require

far more than normal physiologic dosages to overcome their thyroid

hormone resistance. "

As I understand it (and I don't understand it very well at all),

where there is an RT3 situation, the T4 converts into T3 AND RT3.

The RT3 then blocks the thyroid receptors and so they cannot respond

to a normal physiologic dose of T3.

The T3 dose is increased to higher than physiologic doses in order to

waken up the receptors. Then this happens, hyperthyroid status is

temprarily reached and the patient reduces the dose down. She then

stays away from T4 to prevent the situation recurring and keeps her

(or his) TSH suppressed to prevent any naturally-occurring T4 to

enter the system and cause the problem again.

Mo

Mo

> This is Dr Lowe's take on Conversion of T4 to T3 and Reverse-

T3: http://www.drlowe.com/QandA/askdrlowe/thymetab.htm

>

> Luv - Sheila

>

>

> ps. and, of course, if there is an RT3 issue , then you

would

> need to come off any thyroid med with T4 in it AND ensure your

own

> TSH is suppressed so that your body does not add in any more of

your

> own T4 to feed the process.

>

> Mo

>

>

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[Guest guest]

,

You wrote:

> ... I prefer your scenario to Chuck's, but only time will tell

> which is right.

RT3 is another possibility, but since RT3 does have some effect on TSH,

it tends to combine hypoT symptoms with moderate TSH.

Chuck

[Guest guest]

Hi sheila and all, thanks everyone for all the input.I think as my

adrenals are still low and the only thing I can do anything about at

the moment, I,m going to come off the T4 and concentrate on the

adrenals. I going for a blood test today (T4,T3,TSH) ordered by my

endo and I will see her in 5 weeks time. This should Give me 1-2

weeks back on T4 before I see her. I'll post any updates as things

develop.

Best wishes

>

> You wrote:

> > ... I prefer your scenario to Chuck's, but only time will tell

> > which is right.

>

> RT3 is another possibility, but since RT3 does have some effect on

TSH,

> it tends to combine hypoT symptoms with moderate TSH.

>

> Chuck

>

[Guest guest]

Hi Sheila,

hmmm, I thought that is was the other way round- reduces conversion which is why they are contraindicated with hypo and prescribed to ameliorate the symptoms of hyper.

Are you taking any beta-blockers . I believe these can cause high T3?

Luv - Sheila

Hi Chuck, I don't think hyperpituitary can explain my drop in T4 105.0 to 98.5 and 83.0 (ref 58-154) before I started on levthyroxine.Though thinking isn't one of my best attributes at the moment.Thanks for replybest wishes keith

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