Re: The nitty-gritty of TPA-UK!

[Guest guest]

Hi Bob

Why haven't you yet jooined our GabLab forum. This has been created for such people as yourself to keep the science in one place. See you over there. This information would be needed over there.

Luv - Sheila

Hi Chuck

10:00 a.m. and 10:00 p.m. are where the FT3 crossed the center line.In a 24 hour cycle, you have two zero crossings, and they are right where the arrythmia stabilized

This looks like a clue to me, that the half-life for Free T3 must be less than 12 hours else how would it vary rapidly enough to follow this track, causing two 'active' zero crossings in a 24hr period.

Logically, a mechanism of degradation/inactivation has to have evolved to keep track of a 24 hr day, and it would be correspondingly illogical for it to have evolved a half-life of more than 24hrs when the daily requirement is ~ that it (T3) should be 'responsive' well within that period !

A 'periodic' model with a half-life built-in ought to show the limits of the 'possible'.

The et al 2008 'model' should 'fit'....

Bob

-- In thyroid treatment , <gumboyaya@...> wrote:> Bob, , and Sheila,> This paper is one that gives the T3 serum half life other than 8 hours.

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[Guest guest]

That will continue to be done on the GabLab site Dawn - so no worries )

Luv - Sheila

HiyaI will be joining GabLab.I quite like the science papers, sometimes I can even understand themhehe. Is it possible that if a topic is open and someone has posted scienceabout it they could post a link in the thread to it on Gablab? Bobused to point me to some cool stuff.thanksGod blessDawnx

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[Guest guest]

Hi Chuck,

[[...that can becomes apparent (dominates) if there is no T3 input,

either from conversion or ingestion..]]

that was the case, in retrospect.

Bob

> >

> > 10:00 a.m. and 10:00 p.m. are where the FT3 crossed the center

[Guest guest]

Hi Chuck

[[...The half life could be infinite, and you would still have

one high peak and two zero crossings...]]

infinite half-life would imply never reaching a plateau in either

build-up or loss

NO loss No circadian rhythm

Bob

> >

> > 10:00 a.m. and 10:00 p.m. are where the FT3 crossed the center

line.

[Guest guest]

Dear Sheila

Since I can't obtain many of the papers being cited in discussion

currently ~ I can get an abstract if I'm lucky and if I behave myself

~ I have to do extended searches to find alternative sources of

information and I don't have access to Athens, neither do I have

library staff to aid in getting older papers.

I will not participate in scientific discussion that requires

immediate access to the directly relevant (full) papers.

Incomplete citations will not allow me to track what is being

proposed, defended or argued.

best wishes

Bob

> Hi Bob

> Why haven't you yet jooined our GabLab forum. This has been created

[Guest guest]

Then you will have to behave yourself Bob *grin*. If you can get the abstracts, then one of the other scientists who CAN get access could probably get the paper for you, this is what GabLab is all about. Gill has access to Athens. Anyway, I see that you have joined us now and hey, one doesn't have to join in the discussions if one doesn't want. What does the like of li'l ol' Sheila have to offer? I am quite excited about GabLab now.

Luv - Sheila

Dear SheilaSince I can't obtain many of the papers being cited in discussion currently ~ I can get an abstract if I'm lucky and if I behave myself~ I have to do extended searches to find alternative sources of information and I don't have access to Athens, neither do I have library staff to aid in getting older papers.I will not participate in scientific discussion that requires immediate access to the directly relevant (full) papers.Incomplete citations will not allow me to track what is being proposed, defended or argued.best wishesBob > Hi Bob> Why haven't you yet jooined our GabLab forum. This has been created

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[Guest guest]

Hi Miriam,

Are Forest covering all bases on hypothyroid symptoms?

http://en.wikipedia.org/wiki/Forest_Laboratories

http://en.wikipedia.org/wiki/Citalopram

http://www.frx.com/news/PressRelease.aspx?ID=1005671

best wishes

Bob

- 5. One thing that can be done is to destroy Weetman's "functional

[Guest guest]

Hello Bob,

Sorry your message doesn't make any sense to me. Are you sure you

didn't mean to address it to ?

Miriam

- 5. One thing that can be done is to destroy

> Weetman's " functional

>

[Guest guest]

Hi Miriam

[[....There is a section on psychiatry including a couple of papers

criticising the research giving the somatization explanations for CFS.

One interesting point, (page 498) is that " the case for depression

consistently producing immunosuppression is weak, even when the

immunosuppression is measured during the depression " . In other words,

there isn't much evidence for the view that depression leads to

immunosuppression and consequently to the many and varied symptoms of

ME/CFS. ....]]

Forest seem to be looking for a Fibromyalgia drug as illustrated in my

last post....

backing many horses, that could all arise from hypothyroidism (or

hyper~)

Bob

[Guest guest]

There is very little research into the physical aspects of

ME/CFS/Fibromyalgia. Often when it makes the papers the article ends

with the hope of finding a drug to " cure " it. I suppose that reflects

the general strategy of using drugs to alleviate symptoms instead of

looking for root causes and avoiding or preventing the illness in the

first place. :-(

Miriam

> Hi Miriam

> Forest seem to be looking for a Fibromyalgia drug as illustrated in

my last post....

>

> backing many horses, that could all arise from hypothyroidism (or

> hyper~)

>

> Bob