Re: Solid evidence that best treatment for multiple sclerosis is pregnancy

[Guest guest]

Then the stress of having to deal with the babies afterwards causes

another exacerbation or relapse. No thank you! I have three lovely

children, the last 2 were twins and in the first year after birth I

lost partial vision in my left eye. Often the first sign of this

disease. I know that was stress related. They are now 17, 15 & 15

and the stress has not let up ;( I love them to bits, but no more

thankyou!

Kathy

On 26-Oct-04, at 10:30 AM, Cabbie54@... wrote:

> Solid evidence that best treatment for multiple sclerosis is pregnancy

>

> http://www.news-medical.net/?id=4375

>

> Posted By: News-Medical in Medical Research News

> Published: Friday, 27-Aug-2004

>                          

> For years, doctors have suggested the best treatment for multiple

> sclerosis is

> pregnancy. Now, an Oregon study is delivering solid evidence to

> support the theory.

>

> Researchers at Oregon Health & Science University and the Portland

> Veterans Affairs Medical

> Center have uncovered the mechanism by which estrogen, produced in

> high volumes during

> pregnancy, boosts the expression and number of regulatory cells that

> are key to fighting MS

> and other autoimmune diseases, such as arthritis and diabetes.

>

> The study, published in the " Cutting Edge " section of the current

> issue of The Journal of

> Immunology, shows the hormone augments a compartment containing T

> cells known as

> CD4+CD25+, and a regulatory protein called FoxP3. The cells are

> important for protecting mice

> against a model for human MS called experimental autoimmune

> encephalomyelitis (EAE).

>

> Autoimmune disease has been associated with a deficiency of FoxP3,

> whose expression is a

> reliable indicator of the regulatory T cells' function and

> development.

>

> " This is the first report that this single, benign compound – estrogen

> – can increase regulatory

> cells, " said study co-author Halina Offner, Ph.D., professor of

> neurology, and anesthesiology

> and peri-operative medicine, OHSU School of Medicine and the Portland

> VA Medical Center.

> " When you remove (the CD4+CD25+ cells), animals get autoimmune

> disease. They're very

> important to maintaining a healthy state. "

>

> Dennis Bourdette, M.D., professor and chairman of neurology, OHSU

> School of Medicine, and

> director of OHSU's MS Center of Oregon, says understanding how

> estrogens boost protective T

> cells to fight MS will lead to the development of " estrogen-like "

> drugs that could increase the

> cells without the female hormone's side effects.

>

> " Dr. Offner and her research team have made a major breakthrough in

> understanding how

> estrogens help MS, " Bourdette said. " This breakthrough will provide a

> critical 'tool' for developing these new estrogen-like drugs. "

>

> The study found that estrogen treatment simulates pregnancy in

> increasing T cell levels. It also

> demonstrated that estrogen boosts expression of the FoxP3 protein not

> only in a mouse model,

> but also in cell culture. " In vitro, estrogen can induce regulatory

> cells, " Offner added.

>

> In their research, the OHSU-VAMC scientists saw a " significant

> increase " in the number of

> CD4+CD25+ regulatory T cells – 43 percent – and a correlated boost in

> FoxP3 expression in

> mice treated for 14 days with estrogen versus untreated mice.

> Pregnancy increased the

> CD4+CD25+ count and amplified FoxP3 expression as well.

>

> Scientists have long been interested in the role sex hormones play in

> the body's ability to fight

> autoimmune diseases like MS, particularly since these disorders occur

> more frequently in

> females than in males. But the link between pregnancy and MS has been

> hotly debated.

>

> In 1998, scientists in France went a step closer to putting the issue

> to rest when they

> conducted the first large study aimed at assessing pregnancy and

> delivery on the course of the

> disease. The group found there was a marked reduction in the rate of

> MS relapse during

> pregnancy, especially in the third trimester.

>

> Three years later, Offner and a team of OHSU and Portland VA Medical

> Center neurologists

> published a study showing treatment with low doses of estrogen

> protects mice from developing

> EAE, but the mechanism of the effect hadn't been fully characterized.

> And earlier this year,

> researchers in the United Kingdom found that human pregnancy elevated

> levels of the

> disease-fighting CD4+CD25+ T cells.

>

> However, " They didn't say it was (due to) estrogen, " Offner said.

>

> Estrogen levels during pregnancy can be 50 to 100 times higher than

> normal, Offner said.

> Scientists attribute this jump to the body's natural defense against

> its own immune system,

> whose reaction to self-antigen proteins, or " self-Ags, " in fetal

> tissue can lead to fetal rejection,

> as well as the chronic inflammation that is the root of autoimmune

> disease.

>

> " It's very well known that pregnant women are in remission. They do

> feel better, " Offner said. " If

> you could mimic pregnancy somehow, it would be great " as a therapy.

>

> Bourdette said many of his patients have told him their MS symptoms

> improved dramatically

> during pregnancy. And a small clinical trial at the University of

> California, Los Angeles, showed

> estriol, the estrogen hormone produced during pregnancy and available

> as an oral therapy,

> showed " some benefit " for MS patients.

>

> " However, long-term estrogen therapy has potential side effects, " and

> developing estrogen-like

> drugs can help patients avoid these potentially detrimental effects,

> he said.

>

> Research is continuing on regulatory T cells – " T-regs, " as they're

> often called – and their

> potential benefit for other autoimmune diseases, Offner said.

>

> " It would be nice to look at regulatory T cells in an animal model for

> arthritis, " she said. " There's

> still a lot to do. "

>

> The study was supported by grants from the National Institutes of

> Health, the National Multiple

> Sclerosis Society, the MS Center Without Walls, the

> Department of Veterans

> Affairs, the American Diabetes Association and the Juvenile Diabetes

> Research Foundation.

>

>

>

>

>

>

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> don't have or can't do. "

>

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[Guest guest]



----- Original Message -----

From: Cabbie54@...

ndpmultiplesclerosiscaucus ; MSchat@... ; ddarg2@... ; SAVAPET@... ; lswillia@... ; low dose naltrexone ; mendozarjml@... ; nataliamarcu@... ; Shaky036@... ; Pat.Ter.Haar@... ; fthinman@... ; marleneu@... ; wnyselfadvocates

Sent: Tuesday, October 26, 2004 9:30 AM

Subject: [low dose naltrexone] Solid evidence that best treatment for multiple sclerosis is pregnancy

Solid evidence that best treatment for multiple sclerosis is pregnancyhttp://www.news-medical.net/?id=4375 Posted By: News-Medical in Medical Research NewsPublished: Friday, 27-Aug-2004 For years, doctors have suggested the best treatment for multiple sclerosis ispregnancy. Now, an Oregon study is delivering solid evidence to support the theory. Researchers at Oregon Health & Science University and the Portland Veterans Affairs MedicalCenter have uncovered the mechanism by which estrogen, produced in high volumes duringpregnancy, boosts the expression and number of regulatory cells that are key to fighting MSand other autoimmune diseases, such as arthritis and diabetes.

[Guest guest]

The baby's normal endorphin levels causes the mother's endorphin levels to rise

to normal putting her MS in remission and as soon as the baby is born those

endorphin levels start to drop and MS progression begins again.

[Guest guest]



Sorry, I hit "send" accidentally...

Anyway, I know they have been looking at estriol's effect on MS, but it seems simplistic to pick out one hormone in all of the endocrine changes and say that it is responsible. Plus, Pharma has a long record of creating synthetics that are not at all like the natural version, packing side effects and big price tags. Nope, we need to find out what is wrong with us, not create another expensive bandaid.

----- Original Message -----

From:

low dose naltrexone

Sent: Tuesday, October 26, 2004 5:11 PM

Subject: Re: [low dose naltrexone] Solid evidence that best treatment for multiple sclerosis is pregnancy

Subject: [low dose naltrexone] Solid evidence that best treatment for multiple sclerosis is pregnancy

Solid evidence that best treatment for multiple sclerosis is pregnancyhttp://www.news-medical.net/?id=4375 Posted By: News-Medical in Medical Research NewsPublished: Friday, 27-Aug-2004 For years, doctors have suggested the best treatment for multiple sclerosis ispregnancy. Now, an Oregon study is delivering solid evidence to support the theory. Researchers at Oregon Health & Science University and the Portland Veterans Affairs MedicalCenter have uncovered the mechanism by which estrogen, produced in high volumes duringpregnancy, boosts the expression and number of regulatory cells that are key to fighting MSand other autoimmune diseases, such as arthritis and diabetes.

[Guest guest]

This jives with our LDN treatment...

----- Original Message -----

From: Bren

low dose naltrexone

Sent: Tuesday, October 26, 2004 5:32 PM

Subject: [low dose naltrexone] Re: Solid evidence that best treatment for multiple sclerosis is pregnancy

The baby's normal endorphin levels causes the mother's endorphin levels to rise to normal putting her MS in remission and as soon as the baby is born those endorphin levels start to drop and MS progression begins again.

[Guest guest]

Amen !

On 26-Oct-04, at 6:33 PM, wrote:

> Sorry, I hit " send " accidentally...

>  

> Anyway, I know they have been looking at estriol's effect on MS, but

> it seems simplistic to pick out one hormone in all of the endocrine

> changes and say that it is responsible.  Plus, Pharma has a long

> record of creating synthetics that are not at all like the natural

> version, packing side effects and big price tags.  Nope, we need to

> find out what is wrong with us, not create another expensive bandaid.

>  

>

> ----- Original Message -----

> From:

> low dose naltrexone

> Sent: Tuesday, October 26, 2004 5:11 PM

> Subject: Re: [low dose naltrexone] Solid evidence that best treatment

> for multiple sclerosis is pregnancy

>

>  

> Subject: [low dose naltrexone] Solid evidence that best treatment for

> multiple sclerosis is pregnancy

>

>

> Solid evidence that best treatment for multiple sclerosis is pregnancy

>

> http://www.news-medical.net/?id=4375

>

> Posted By: News-Medical in Medical Research News

> Published: Friday, 27-Aug-2004

>                          

> For years, doctors have suggested the best treatment for multiple

> sclerosis is

> pregnancy. Now, an Oregon study is delivering solid evidence to

> support the theory.

>

> Researchers at Oregon Health & Science University and the Portland

> Veterans Affairs Medical

> Center have uncovered the mechanism by which estrogen, produced in

> high volumes during

> pregnancy, boosts the expression and number of regulatory cells that

> are key to fighting MS

> and other autoimmune diseases, such as arthritis and diabetes.

>

>

>

>

>

>

>

>

>

[Guest guest]

Hello Group,

Just so you all know. Estriol is a bioidentical estrogen, not a manufactured synthetic substitute.

Wayne Loveland, R.Ph.

----- Original Message -----

From: Kathy Huget

low dose naltrexone

Sent: Tuesday, October 26, 2004 7:34 PM

Subject: Re: [low dose naltrexone] Solid evidence that best treatment for multiple sclerosis is pregnancy

Amen !On 26-Oct-04, at 6:33 PM, wrote:

Sorry, I hit "send" accidentally... Anyway, I know they have been looking at estriol's effect on MS, but it seems simplistic to pick out one hormone in all of the endocrine changes and say that it is responsible. Plus, Pharma has a long record of creating synthetics that are not at all like the natural version, packing side effects and big price tags. Nope, we need to find out what is wrong with us, not create another expensive bandaid. ----- Original Message -----From: low dose naltrexone Sent: Tuesday, October 26, 2004 5:11 PMSubject: Re: [low dose naltrexone] Solid evidence that best treatment for multiple sclerosis is pregnancy Subject: [low dose naltrexone] Solid evidence that best treatment for multiple sclerosis is pregnancySolid evidence that best treatment for multiple sclerosis is pregnancyhttp://www.news-medical.net/?id=4375 Posted By: News-Medical in Medical Research NewsPublished: Friday, 27-Aug-2004 For years, doctors have suggested the best treatment for multiplesclerosis ispregnancy. Now, an Oregon study is delivering solid evidence to support the theory.Researchers at Oregon Health & Science University and the PortlandVeterans Affairs MedicalCenter have uncovered the mechanism by which estrogen, produced in high volumes duringpregnancy, boosts the expression and number of regulatory cells that are key to fighting MSand other autoimmune diseases, such as arthritis and diabetes.

[Guest guest]

I wasn't opposing Estriol, but the synthetic version that is bound to follow this research.

----- Original Message -----

From: Wayne Loveland

low dose naltrexone

Sent: Wednesday, October 27, 2004 6:38 AM

Subject: Re: [low dose naltrexone] Solid evidence that best treatment for multiple sclerosis is pregnancy

Hello Group,

Just so you all know. Estriol is a bioidentical estrogen, not a manufactured synthetic substitute.

Wayne Loveland, R.Ph.

----- Original Message -----

From: Kathy Huget

low dose naltrexone

Sent: Tuesday, October 26, 2004 7:34 PM

Subject: Re: [low dose naltrexone] Solid evidence that best treatment for multiple sclerosis is pregnancy

Amen !On 26-Oct-04, at 6:33 PM, wrote:

Sorry, I hit "send" accidentally... Anyway, I know they have been looking at estriol's effect on MS, but it seems simplistic to pick out one hormone in all of the endocrine changes and say that it is responsible. Plus, Pharma has a long record of creating synthetics that are not at all like the natural version, packing side effects and big price tags. Nope, we need to find out what is wrong with us, not create another expensive bandaid. ----- Original Message -----From: low dose naltrexone Sent: Tuesday, October 26, 2004 5:11 PMSubject: Re: [low dose naltrexone] Solid evidence that best treatment for multiple sclerosis is pregnancy Subject: [low dose naltrexone] Solid evidence that best treatment for multiple sclerosis is pregnancySolid evidence that best treatment for multiple sclerosis is pregnancyhttp://www.news-medical.net/?id=4375 Posted By: News-Medical in Medical Research NewsPublished: Friday, 27-Aug-2004 For years, doctors have suggested the best treatment for multiplesclerosis ispregnancy. Now, an Oregon study is delivering solid evidence to support the theory.Researchers at Oregon Health & Science University and the PortlandVeterans Affairs MedicalCenter have uncovered the mechanism by which estrogen, produced in high volumes duringpregnancy, boosts the expression and number of regulatory cells that are key to fighting MSand other autoimmune diseases, such as arthritis and diabetes.