Re: Vitamin D ~ what more can I say?

[Guest guest]

Hi Bob

I dont understand what this means.

Can you explain in simple please.

Chris

>

> CCAAT ENHANCER BINDING PROTEIN ÁLPHA IS A MOLECULAR TARGET OF

> 1,25DIHYDROXYVITAMIN D3 IN MCF 7 BREAST CANCER CELLS

>

> http://www.jbc.org/cgi/doi/10.1074/jbc.M803602200

>

> JBC Papers in Press. Published on December 3, 2008 as

> Manuscript M803602200

>

> [[....INTRODUCTION

> Vitamin D, in order to exert its effects, must be metabolized to

its

> most active form, 1,25dihydroxyvitaminD3 (1,25(OH)2D3) (1).

> The actions of 1,25(OH)2D3 include not only maintenance of calcium

> homeostasis but also effects on numerous other systems including

> effects on the immune system and the growth and differentiation of

a

> number of malignant cells including breast cancer cells (1).

>

> 1,25(OH)2D3 acts by binding to a high affinity intracellular

receptor

> protein (the vitamin D receptor or VDR). 1,25(OH)2D3 bound to the

VDR

> heterodimerizes with the retinoid X receptor (RXR) and along with

> coactivators and additional accessory nuclear proteins interacts

with

> vitamin D response elements (VDREs) in the promoter of target

genes

> and modulates their transcription (1). .....]]

>

[Guest guest]

Bob - my calcium tablets contain Vit D3 - should I not take it?

Chris

>

> CCAAT ENHANCER BINDING PROTEIN ÁLPHA IS A MOLECULAR TARGET OF

> 1,25DIHYDROXYVITAMIN D3 IN MCF 7 BREAST CANCER CELLS

>

> http://www.jbc.org/cgi/doi/10.1074/jbc.M803602200

>

> JBC Papers in Press. Published on December 3, 2008 as

> Manuscript M803602200

>

> [[....INTRODUCTION

> Vitamin D, in order to exert its effects, must be metabolized to

its

> most active form, 1,25dihydroxyvitaminD3 (1,25(OH)2D3) (1).

> The actions of 1,25(OH)2D3 include not only maintenance of calcium

> homeostasis but also effects on numerous other systems including

> effects on the immune system and the growth and differentiation of

a

> number of malignant cells including breast cancer cells (1).

>

> 1,25(OH)2D3 acts by binding to a high affinity intracellular

receptor

> protein (the vitamin D receptor or VDR). 1,25(OH)2D3 bound to the

VDR

> heterodimerizes with the retinoid X receptor (RXR) and along with

> coactivators and additional accessory nuclear proteins interacts

with

> vitamin D response elements (VDREs) in the promoter of target

genes

> and modulates their transcription (1). .....]]

>

[Guest guest]

Hi

From my brief reading of this paper, it says Vit D3 should help with

breast cancer prevention and potentially with remission also.

I'll have to re-read it, to make sure I've understood it correctly.

best wishes

Bob

>

> Hi Bob

>

> I dont understand what this means.

>

> Can you explain in simple please.

>

> Chris

>

[Guest guest]

I haven't had a chance to read the report and Bob's post is confusing

me. Bob are you saying that taking Vit D3 will cause breast cancer?

I take 50,000units of D once a week and this has me concerned if this

is what you are saying. Also, my husband takes D at 50,000 units which

he just started today.

Venizia

> Bob - my calcium tablets contain Vit D3 - should I not take it?

> Chris

[Edit Abbrev Mod]

[Guest guest]

Hi Venezia,

On a first reading, I came to the conclusion that Vit D3 is likely to

prevent and/or cause remission of breast cancer.

Whether it is advisable to use such a large excess of Vit D3, I don't

know, and I'm going to have to re-read the letter from Cannell

et al, posted elsewhere recently on this topic.

Bob

> > Bob - my calcium tablets contain Vit D3 - should I not take it?

> > Chris

>

>

>

> [Edit Abbrev Mod]

>

[Guest guest]

Bob,

I am wondering if the high dose is ok as long as one stays within

normal levels. When I was first diagnose with low levels, I was at 18

and my level at its highest was 75 I believe which is still within the

normal ranges. How could it be bad then?

Venizia

> Hi Venezia,

> On a first reading, I came to the conclusion that Vit D3 is likely to

> prevent and/or cause remission of breast cancer.

[Edit Abbrev Mod]

[Guest guest]

Hi

My understanding is that it is OK to take Calcium with Vit D (VitD3 for

preference) ~ I'm not so sure about the 'large excess of Vit D3' and I

will need to re-read the recent article from Cannell and partners

on just this subject.

Bob

[Guest guest]

Hi Venizia

That was my understanding of the recent paper by Cannell et al.

I suspect the thinking is along the lines of 'test if using high

doses'.

Bob

> > Hi Venezia,

> > On a first reading, I came to the conclusion that Vit D3 is

likely to

> > prevent and/or cause remission of breast cancer.

>

>

>

> [Edit Abbrev Mod]

>

[Guest guest]

Awesome, thanks Bob

[Guest guest]

Hi Bob

This is an interesting write-up on Vit D:

http://slate.msn.com/id/2105560/

From other reading on the subject it seems that perhaps in a minority

of people 2000iu per day is too high.

For my part, Ive been taking an average of 2500iu for a good 2

months, & whether this is the reason or not have been feeling a lot

healthier than usual in these gloomy months of the year. I'm inclined

to believe the people who say that Vit D is to be much preferred over

a flu jab.

Rgds

Hans

>

> Hi

>

> From my brief reading of this paper, it says Vit D3 should help

with

> breast cancer prevention and potentially with remission also.

....

best wishes

> Bob