Guest guest Posted November 30, 2008 Report Share Posted November 30, 2008 Hertoghe TM, Hertoghe Th, Gadomski A, François M, Everard B, Duboé B Melatonin and Sleep: a Review J Eur Anti-Aging Med. 2005; 1: 32-7 A total of 199 human studies (196 different publications) on the relationship between melatonin and sleep, were found through a search on Pubmed, the Internet medical Medline databank: 58 observational and 141 treatment studies. 71% of the observational studies showed a beneficial positive association between the serum or urinary level of melatonin or of one of its metabolites and sleep. 98 of the treatment studies were placebo-controlled studies with 82 (84 %) of them showing significant beneficial results of melatonin supplementation on sleep. Most frequent beneficial effects were a reduction of sleep onset, an efficient muscle relaxation, better resynchronisation of advanced or delayed sleep phase syndromes, and restorations of circadian temperature and sleep-wake cycles. Slow wave sleep and REM stages were rarely significantly improved. Quote Link to comment Share on other sites More sharing options...
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