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You don't have to have any allergies to have a reaction to toxic molds!! My

problems were all respiratory ( coughing, sinus, bronchitis, post nasal

drip, sore throats, etc.) before the neurological problems began. I suggest you

take the VCS test on line at _www.chronicneurotoxins.com_

(http://www.chronicneurotoxins.com) . It is inexpensive & very accurate! If

you test positive

you can be fairly certain that you have been exposed to toxic mold. Then you

need to find a Dr. that can help you.

Hello everyone,

I am frustrated and hoping someone might be able to help me. I will

try to give you the short story. I started teaching about 6 six

years ago. Since then I have had numerous cases of bronchitis

increasing in length and frequency each year. Prior to this, I was

free of any respiatory illnesses. A little over a year ago at 30 I

was diagnosed with Asthma.

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Colleen

Some do not respond positively to allergy tests for mold. It could also be

that you are reacting to mycotoxin which they probably did not test you for. I

even knew someone who showed no mold exposure in her blood stream even though

she had high levels of tricothecene mycotoxin in her urine. Sometimes when a

person's immune system becomes too compromised and shuts down, it does not

produce antibodies to mold during the tests (skin and/or blood).

Kathy

Colleen <cpkelly2@...> wrote:

Hello everyone,

I am frustrated and hoping someone might be able to help me. I will

try to give you the short story. I started teaching about 6 six

years ago. Since then I have had numerous cases of bronchitis

increasing in length and frequency each year. Prior to this, I was

free of any respiatory illnesses. A little over a year ago at 30 I

was diagnosed with Asthma.

3 months ago I had a series of progressively worse asthma attacks

landing me in the ER. On the third visit I was admitted to ICU and

was in the hosptial for 10 days. I have been out of work since and

am on countless medications. I attempted to go back to work last

week and was there a day and a half before I was back in the

hospital. Thankfully just an overnight stay this time.

I have had allery testing done and the allergist claims I am not

allergic to anything. The school library was shut down 2 years ago

to clean mold for two months. Currently a classroom has been closed

due to the mold and is being completly redone.

I have been being treated by a pulonologist since the first hosptial

visit, but I am not sure if there is anything else i should be doing.

Can it still be the building if they say I am not allergic to

anything.

Any help would be appreciated!!

COL

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Colleen,

I hope this fact sheet will help you understand a little more.

KC

http://www.germology.com/indoor_mold.htm

FACT SHEETS

HEALTH EFFECTS OF INDOOR MOLD

Exposure to indoor fungi and their biochemical products may occur by

means of one or more routes or " pathways " : 1) inhalation (breathing

of inhaled spores, spore fragments, or volatile compounds), 2)

absorption or dermal contact (contact with skin), and 3) ingestion

(consuming contaminated materials). Inhalation and dermal contact

represent the most probable exposure pathways for occupants under

typical indoor conditions.

The presence of fungi on indoor building materials does not present

unequivocal proof of exposure. Cells, spores, cell fragments, or

metabolites must first come in contact with the occupant. This is

often achieved by direct contact with contaminated materials or by

indirect contact after contaminants become aerosolized and disperse

to areas not directly affected by fungal growth or water damage.

Depending on the location and extent of contamination, air currents

within buildings and homes as well as normal occupant activities are

sufficient to disperse fungal contaminants. Remediation activities

may cause even greater releases of aerosolized microbes (Rautiala et

al, 1996). Microbial contamination within concealed building

cavities also poses concerns for occupant exposure as spore

dispersal may occur via through-wall openings and structural

joints. Exposure assessments must also account for the fact that

nonviable (i.e. dead) spores retain their allergenic, irritant, and

toxigenic properties. The viability of fungal contaminants is

therefore irrelevant when considering risks other than infection.

Cell or spore fragments, which are not measured by routine sampling,

also retain their physical properties. Cell fragments may actually

present even greater risks because their smaller size enables deeper

penetration into airway passages (Gorny et al., 2002). Furthermore,

many common contaminants produce metabolites called Volatile Organic

Compounds (VOCs) that readily migrate through building materials

such as wood sheathing, concrete, drywall, and even plastic vapor

barriers.

Health effects caused by fungal contaminants are difficult to

predict and reactions depend on several important variables such as

duration and frequency of exposure, concurrent exposures to other

sources (e.g. outdoor fungi), the type of agents involved, the

physiological condition of the agent, and the sensitivity of the

exposed individual. Still, it is well established that fungi cause

or exacerbate numerous ailments (Ajello and Hay, 1998; AAP, 1998;

Burge and Ammann, 1999; Croft et al., 2002; Hardin et al., 2003;

Horner, et. al., 1995; Yang and Johanning, 1996). Examples of

typical mold-related effects include cough, congestion, wheezing,

chest tightness, runny nose, headaches, flu-like symptoms, muscle

and joint pain, fatigue, dizziness, nosebleeds, eye irritations,

infections, confusion, memory loss, and anxiety. Furthermore,

exposures to fungal antigens and irritants such as proteins, beta-(1-

->3)-D-Glucans, mycotoxins, and other secondary metabolites may have

complex results with unknown etiological mechanisms.

Allergy effects

The contaminants documented by this investigation may cause short

and long-term hypersensitive reactions (allergies). Hypersensitive

reactions are exaggerated immune responses resulting in tissue

inflammation or damage. Such responses are categorized based on the

timing of the reaction as well as the nature of the immune

components involved. The most common allergenic responses caused by

fungi include Type I, Type III, and Type IV hypersensitivities

(Burge and Otten, 1999; Horner et al., 1995; Yang and Johanning,

1996). Type I hypersensitivities involve an immediate but localized

response to allergens such as fungi, pollen, dust mites, or animal

dander. By virtue of common components of spore walls, most fungi

are capable of causing Type I reactions. Type I responses are

mediated by a particular class of circulating antibodies

or " immunoglobulins " referred to as IgE, which can be detected

directly by antigen-specific analyses of blood serum or indirectly

by allergy skin tests. Common symptoms of a Type I response include

itchy or watery eyes, runny nose, sinusitis, coughing or sneezing,

congestion, chest tightness, and shortness of breath.

Type III hypersensitivities involve delayed responses (usually

within hours or days) caused by the formation of insoluble antigen-

antibody complexes. These complexes migrate within the blood stream

and may eventually cause acute inflammation, constriction of blood

vessels, and tissue necrosis. Such reactions may persist for weeks

or even months following the last known exposures. Examples of this

type of disorder include " Farmer's Lung " and Hypersensitivity

Pneumonitis, both of which are caused by wide variety of fungi and

other microorganisms. Type III reactions are mediated primarily by

antibodies referred to as IgG and IgM, which are best assessed by

antigen-specific analyses of blood serum. Symptoms of Type III

hypersensitivities may include fatigue, muscle and joint pain,

respiratory disorders, chest pressure, and general flu-like

symptoms.

Type IV hypersensitivities or " delayed hypersensitive reactions " are

not mediated by antibodies. Instead, these reactions are mediated

by T-Cells, a type of lymphocyte produced in bone marrow and

modified within the thymus. Delayed hypersensitive reactions are

wholly or partly responsible for extrinsic allergic alveolitis and

contact dermatitis - a common skin disorder resulting in

inflammatory responses to antigens such as detergents, solvents,

poison ivy, latex, and various cell wall components or metabolites

of fungi.

Irritant effects

Irritants are biological, physical, or chemical substances that

cause cellular changes in epithelial, connective, nervous, or muscle

tissue. Although the terms " irritant " and " allergen " are often used

synonymously, the term " irritant " is typically used to denote

symptoms that cannot be diagnosed or explained by other etiological

mechanisms, including immune responses. Because conditions caused

by allergens and irritants are manifested as similar inflammatory

responses, careful evaluation is necessary for proper diagnosis. For

example, conditions such as bronchitis, rhinitis, sinusitis, and

conjunctivitis (inflammation of the eye) are the result of allergic

and irritant (non-allergic) responses. Allergy symptoms such as

airway constriction, headache, fatigue, nausea, and memory loss, and

inability to concentrate are also caused by irritants. In many

instances multiple etiological mechanisms and their respective

symptoms may coexist and the cause might not be distinguished by

routine or even specialized medical evaluations. Diagnostics for

irritants such as VOCs, mycotoxins, endotoxins, or other cell wall

constituents may be altogether lacking; and it may therefore be

extremely difficult to establish definitive causation.

Most fungal contaminants produce spores, cell wall constituents,

VOCs, and other metabolites that cause irritations in a wide variety

of tissue types. Of particular concern are irritations caused by

fungal glucans and VOCs (Volatile Organic Compounds). Glucans

represent structural components in cell walls of most fungi as well

as some bacteria and plants. Glucan exposures are expected wherever

fungi occur in high abundance. Symptoms such as chest tightness,

cough, shortness of breath, and wheezing are suggestive of glucan

inhalation in susceptible individuals or for otherwise healthy

individuals exposed to high levels of airborne fungi (Burge and

Ammann, 1999; Rylander and Lin, 2000). Volatile organic compounds

are chemical irritants responsible for the moldy or musty odors

often associated with microbial contamination. Other common odors

are described as being chemical, sweet, or pungent. It is important

to note that not all VOCs are detectable by human sensory

receptors. In other words, the absence of odors does not rule out

the possibility of irritant effects. Examples of VOCs produced by

fungal contaminants include hexanol, benzene, toluene, acetone, 2-

butanone, cyclohexane, and ethanol. Although the etiological

mechanisms remain poorly defined, some of the symptoms of VOC-

exposure include headache, nausea, rhinitis (runny nose), acute or

chronic respiratory effects, attention deficit, and inability to

concentrate (Ammann, 1999).

Toxic effects

Many species of fungi produce cell wall substances (e.g. proteins

and glucans) and secondary metabolites (e.g. mycotoxins and volatile

organic compounds) that are toxic to humans and other animals (Burge

and Ammann, 1999). Because glucans and mycotoxins have low

volatility they are not readily removed from the spore. So it is

presumed that wherever spores are found, toxic cell wall components

may also be present. As previously discussed, fungal cells/spores

retain their toxigenic properties regardless of whether the cell is

actually alive or dead.

Mycotoxins are toxic metabolites produced by certain species of

fungi. Although a given fungal species may produce several

mycotoxins, a particular mycotoxin is often produced by more than

one genus or species. Toxin production is also highly variable with

regards to environmental conditions and the metabolized substrate.

As a precautionary measure, it is assumed that if toxigenic species

are present, the associated mycotoxins may also be present. Still,

irritant or toxic effects are dependent on a number of variables

including the toxin type and concentration, the exposure pathway,

and the susceptibility of exposed individuals. Epidemiological

investigations involving airborne exposures suggest that mycotoxins

cause a variety of human diseases. The significance of these

findings has been previously assessed by several peer-reviewed

publications (American Academy of Pediatrics, 1998; Burge and

Ammann, 1999; Dearborn et al., 2002; Health Canada, 1995; Hendry and

Cole, 1993; Yang and Johanning, 1996). Common complaints associated

with mycotoxins include depression, headaches, fatigue, muscle and

joint pains, nausea, and upper or lower respiratory disorders. Other

symptoms may include chills, fever, tremors, sensitized skin,

numbness, vasoconstriction, nosebleeds, blood in feces or urine,

immune dysfunction, and altered conditions involving the central and

peripheral nervous systems.

Despite the growing evidence supporting a causal relationship

between airborne mycotoxins and health effects (Croft et al., 2002),

mycotoxicosis due to inhalation of indoor spores remains highly

controversial (Robbins et al., 2000; Hardin et al., 2003). The

amount of toxins contained in aerosolized spores, even at high

levels, may be insufficient to cause classical mycotoxin poisoning

such as that caused by mycotoxin-contaminated food. Nonetheless,

many mycotoxin-related effects may actually involve mechanisms not

explained by conventional dose-response models. In other words, the

mycotoxins could act as irritants or allergens. The synergistic

effects of mycotoxins, VOCs, and fungal glucans also remain unknown

and it is conceivable that such complex mixtures could account for

effects that are otherwise unsubstantiated by quantified mycotoxin

concentrations in sampled spores.

Exposures to complex and nonspecific mixtures of compounds such as

fungal toxins, bacterial endotoxins, fungal proteins, and glucans

may result in non-allergenic, noninfectious lung reactions termed

Organic Dust Toxic Syndrome (ODTS). The clinical features of ODTS

resemble a flu-like illness and include breathing difficulty, cough,

headaches, fever & chills, fatigue, acute inflammatory lung

reaction, and negative chest X-ray (Burge and Ammann, 1999; Yang and

Johanning, 1996). The symptoms of ODTS (also called toxic

pneumonitis) are also very similar to a hypersensitive reaction

called hypersensitivity pneumonitis or extrinsic allergic

alveolitis; however, ODTS differs by being nonallergenic, thus high

antibody precipitins are not formed.

Infectious Agents

Fungal infections in healthy individuals are relatively rare.

Nonetheless, many common indoor contaminants represent potentially

infectious agents that are capable of causing localized and systemic

infections in susceptible individuals (Ajello and Hay, 1998).

Conditions such as antibiotic treatment, steroid treatment,

chemotherapy, and immune disorders are examples of predisposing or

susceptible or pre-disposed states. Children, pregnant women, and

elderly individuals also show greater susceptibility.

Literature Cited

ACGIH. 1999. Bioaerosols Assessment and Control. (J. Machler, Ed.).

American Conference of Industrial Hygienists, Cincinnati, OH.

Ajello, L. and R. Hay. 1998. Topley & 's Microbiology and

Microbial Infections, 9th ed., Vol. 4: Medical Mycology,

Arnold, New York.

American Academy of Pediatrics (AAP). 1998. Toxic effects of indoor

molds. Pediatrics 101:712-714.

Ammann, H.M. 1999. Microbial Volatile Organic Compounds. In:

Bioaerosols Assessment and Control. (J. Machler, Ed.). American

Conference of Industrial Hygienists, Cincinnati, OH.

Burge, H.A. and H.A. Ammann. 1999. Fungal Toxins and b-(1®3)-D-

Glucans. In: Bioaerosols Assessment and Control. (J. Machler, Ed.).

American Conference of Industrial Hygienists, Cincinnati, OH.

Burge, H.A. and J.A. Otten. 1999. Fungi. In: Bioaerosols Assessment

and Control. (J. Machler, Ed.). American Conference of Industrial

Hygienists, Cincinnati, OH.

Croft, W.A., B.M. Jastromski, A.L. Croft, and H.A. s. 2002.

Clinical Confirmation of Trichothecene Mycotoxicosis in Patient

Urine. J. Environ. Biol. 23:301-320.

Gorny R.L., T. Reponen, K. Willeke, D. Schmechel, E. Robine, M.

Boissier, and S.A. Grinshpun. 2002. Fungal Fragments as Indoor Air

Biocontaminants. Appl Environ Microbiol. 68:3522-3531.

Hardin, B.D., B.J. Kelman, and A. Saxon. 2003. Adverse Human Health

Effects Associated with Molds in the Indoor Environment. J. Occup.

Environ. Med. 45:470-478.

Health Canada. 1995. Fungal Contamination in Public Buildings: A

Guide to Recognition and Management. Federal-Provincial Committee

on Environmental and Occupational Health, Ottawa, Ontario.

Hendry, K.M. and E.C. Cole. 1993. A Review of Mycotoxins in Indoor

Air. Journal of Toxicology and Environmental Health 38:183-198.

Horner, W.E., A. Helbling, and J.E. Salvaggio.1995. Fungal

allergens. Clin. Micro. Rev. 8:161-179.

Milton, D.K. 1999. Endotoxins and Other Bacterial Cell-Wall

Components. In: Bioaerosols Assessment and Control. (J. Machler,

Ed.). American Conference of Industrial Hygienists, Cincinnati, OH.

Olenchock, S.A. 1996. Airborne Endotoxin In: Manual of Environmental

Microbiology, C. Hurst (Editor in Chief), ASM Press, Washington, D.C.

Rautiala, S., T. Reponen, A. Hyvarinen, A. Nevalainen, T. Husman, A.

Vehvilainen, Pentti Kalliokoski. 1996. Exposure to Airborne Microbes

During the Repair of Moldy Buildings. AIHA Journal 57:279-284.

Robbins, C. A., L.J. Swenson, M.L. Nealley, B.J. Kelman, and R.E.

Gots. 2000. Health Effects of Mycotoxins in Indoor Air: A Critical

Review. Applied Occupational and Environmental Hygiene 15:773-784

Rylander, R. and R.H. Lin. 2000. (1®3)-Beta-D-Glucan – Relationship

to Indoor Air-Related Symptoms, Allergy and Asthma. Toxicology

152:47-52.

Wallace, L.A. 1997. Sick Building Syndrome. In: Indoor Air Pollution

and Health E.J. Bardana Jr. and A. Montanaro (Eds). Marcel Dekker,

Inc., New York.

Yang C., and E. Johanning, 1996. Airborne Fungi and Mycotoxins, In:

Manual of Environmental Microbiology, C. Hurst (Editor in Chief),

ASM Press, Washington, D.C.

--- In , " Colleen " <cpkelly2@h...>

wrote:

>

> Hello everyone,

>

> I am frustrated and hoping someone might be able to help me. I

will

> try to give you the short story. I started teaching about 6 six

> years ago. Since then I have had numerous cases of bronchitis

> increasing in length and frequency each year. Prior to this, I

was

> free of any respiatory illnesses. A little over a year ago at 30

I

> was diagnosed with Asthma.

>

> 3 months ago I had a series of progressively worse asthma attacks

> landing me in the ER. On the third visit I was admitted to ICU and

> was in the hosptial for 10 days. I have been out of work since

and

> am on countless medications. I attempted to go back to work last

> week and was there a day and a half before I was back in the

> hospital. Thankfully just an overnight stay this time.

> I have had allery testing done and the allergist claims I am not

> allergic to anything. The school library was shut down 2 years

ago

> to clean mold for two months. Currently a classroom has been

closed

> due to the mold and is being completly redone.

> I have been being treated by a pulonologist since the first

hosptial

> visit, but I am not sure if there is anything else i should be

doing.

> Can it still be the building if they say I am not allergic to

> anything.

>

> Any help would be appreciated!!

> COL

>

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Asthma headache and skin problems Yeast infection women must wash hands before

going to the toilet in the Think you are living in mold. the Doctor sure want

tell you this I learn the hard way before and after you must wash your hands.

1.allergist claims I am not

allergic to anything.

see another allergist and say nothing about mold or any thing else let them tell

you.

2.The school library was shut down 2 years ago

to clean mold for two months. Currently a classroom has been closed

due to the mold and is being completely redone.

There's some type of problem in the past 10 to 5 years in the Air-condition

system it's very bad on a tree it looks light green but around the AC it's black

beware,New Buildings most of all.

3.Can it still be the building if they say I am not allergic to

anything.

Yes it could also be in your home as well it's every where and getting much

worse hummmmmm question is who will stand tall on this issue we need to stay on

top of State, City,County, and the Congress. also try to get people like Oprah

to do shows on it also Dr Phil.

WETHEPEOPLE

Elvira

[] Looking for Help

Hello everyone,

I am frustrated and hoping someone might be able to help me. I will

try to give you the short story. I started teaching about 6 six

years ago. Since then I have had numerous cases of bronchitis

increasing in length and frequency each year. Prior to this, I was

free of any respiatory illnesses. A little over a year ago at 30 I

was diagnosed with Asthma.

3 months ago I had a series of progressively worse asthma attacks

landing me in the ER. On the third visit I was admitted to ICU and

was in the hosptial for 10 days. I have been out of work since and

am on countless medications. I attempted to go back to work last

week and was there a day and a half before I was back in the

hospital. Thankfully just an overnight stay this time.

I have had allery testing done and the allergist claims I am not

allergic to anything. The school library was shut down 2 years ago

to clean mold for two months. Currently a classroom has been closed

due to the mold and is being completly redone.

I have been being treated by a pulonologist since the first hosptial

visit, but I am not sure if there is anything else i should be doing.

Can it still be the building if they say I am not allergic to

anything.

Any help would be appreciated!!

COL

FAIR USE NOTICE:

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Where would you get this urine test done? Loni

Treat <treats4you@...> wrote: Colleen

Some do not respond positively to allergy tests for mold. It could also be

that you are reacting to mycotoxin which they probably did not test you for. I

even knew someone who showed no mold exposure in her blood stream even though

she had high levels of tricothecene mycotoxin in her urine. Sometimes when a

person's immune system becomes too compromised and shuts down, it does not

produce antibodies to mold during the tests (skin and/or blood).

Kathy

Colleen <cpkelly2@...> wrote:

Hello everyone,

I am frustrated and hoping someone might be able to help me. I will

try to give you the short story. I started teaching about 6 six

years ago. Since then I have had numerous cases of bronchitis

increasing in length and frequency each year. Prior to this, I was

free of any respiatory illnesses. A little over a year ago at 30 I

was diagnosed with Asthma.

3 months ago I had a series of progressively worse asthma attacks

landing me in the ER. On the third visit I was admitted to ICU and

was in the hosptial for 10 days. I have been out of work since and

am on countless medications. I attempted to go back to work last

week and was there a day and a half before I was back in the

hospital. Thankfully just an overnight stay this time.

I have had allery testing done and the allergist claims I am not

allergic to anything. The school library was shut down 2 years ago

to clean mold for two months. Currently a classroom has been closed

due to the mold and is being completly redone.

I have been being treated by a pulonologist since the first hosptial

visit, but I am not sure if there is anything else i should be doing.

Can it still be the building if they say I am not allergic to

anything.

Any help would be appreciated!!

COL

FAIR USE NOTICE:

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The test was done through a labe called NeuroScience. They are in Wisconsin.

Phone number 715 755 3995

Kathy

Loni Rosser <loni326@...> wrote:

Where would you get this urine test done? Loni

Treat <treats4you@...> wrote: Colleen

Some do not respond positively to allergy tests for mold. It could also be

that you are reacting to mycotoxin which they probably did not test you for. I

even knew someone who showed no mold exposure in her blood stream even though

she had high levels of tricothecene mycotoxin in her urine. Sometimes when a

person's immune system becomes too compromised and shuts down, it does not

produce antibodies to mold during the tests (skin and/or blood).

Kathy

Colleen <cpkelly2@...> wrote:

Hello everyone,

I am frustrated and hoping someone might be able to help me. I will

try to give you the short story. I started teaching about 6 six

years ago. Since then I have had numerous cases of bronchitis

increasing in length and frequency each year. Prior to this, I was

free of any respiatory illnesses. A little over a year ago at 30 I

was diagnosed with Asthma.

3 months ago I had a series of progressively worse asthma attacks

landing me in the ER. On the third visit I was admitted to ICU and

was in the hosptial for 10 days. I have been out of work since and

am on countless medications. I attempted to go back to work last

week and was there a day and a half before I was back in the

hospital. Thankfully just an overnight stay this time.

I have had allery testing done and the allergist claims I am not

allergic to anything. The school library was shut down 2 years ago

to clean mold for two months. Currently a classroom has been closed

due to the mold and is being completly redone.

I have been being treated by a pulonologist since the first hosptial

visit, but I am not sure if there is anything else i should be doing.

Can it still be the building if they say I am not allergic to

anything.

Any help would be appreciated!!

COL

FAIR USE NOTICE:

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  • 1 year later...

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