For Bob

[Guest guest]

Hello Bob

Just out of interest how much thyroxine does your wife now take along

with the HC? Dr P seems to think my fast, hard heart beat last night

was a sign of too much T4, I have been on 75mcg for 9 days and previous

to that 50mcg for a week, my pulse has risen slightly and like I have

said I am aware of my heart beat sometimes but have had no other signs

of going hyper apart from maybe the anxiety?

I really dont know if to stick it out and see if it settles or reduce

back to 50mcg. I realise the cortisone is doing its job so I wont need

as much T4. Another thought is that maybe taking it at night is wrong

for me so am going back to taking it in the mornings but at 75mcg or

50mcg, I seem thing things may settle as the dose stabalizes

[Guest guest]

I think maybe I will drop to 50mcg, my heart is beating faster, I can feel it now while sitting and here was me thinking I need more, how confusing this all is, I wont take any tonight and start 50 in the morning I think, the faster heart beat is only adding to the anxiety--- On Wed, 17/9/08, xxsarahxx_40 <xxsarahxx_40@...>

Hello BobJust out of interest how much thyroxine does your wife now take along with the HC? Dr P seems to think my fast, hard heart beat last night was a sign of too much T4, I have been on 75mcg for 9 days and previous to that 50mcg for a week, my pulse has risen slightly and like I have said I am aware of my heart beat sometimes but have had no other signs of going hyper apart from maybe the anxiety?I really dont know if to stick it out and see if it settles or reduce back to 50mcg. I realise the cortisone is doing its job so I wont need as much T4. Another thought is that maybe taking it at night is wrong for me so am going back to taking it in the mornings but at 75mcg or 50mcg, I seem thing things may settle as the dose stabalizes

[Guest guest]

Hi Lilian,

I wonder if Chuck might be able to get a copy for us?

It's one of those papers without an abstract and we can't read it without paying

a fee.

I cannot possibly do that for the number of papers I scan or read.

I've been waiting some time to see that particular one, myself.

It may be 'released' after 6-12mths.

best wishes

Bob

>

> Hi Bob,

>

> You have put in the files " Thyroid Replacement Might Not Be Enough........ "

but I cannot read it. Is there some way you can tell us what it says or how we

can read about it.

>

> Lilian

>

[Guest guest]

Hi Lilian,

I'm also trying to dream up ways to make the information easier to access.

Sheila suggested we use the Links more often ~ which I now do.

Using folders may be helpful in some respects, but I tend to think the more that

is directly visible, the better....long titles are also a bit unwieldy....trying

to balance informative content with brevity is always a nightmare ?

Bob

>

> Hi Bob,

>

> You have put in the files " Thyroid Replacement Might Not Be Enough........ "

but I cannot read it. Is there some way you can tell us what it says or how we

can read about it.

>

> Lilian

>

[Guest guest]

Thanks Bob.

As it seems to be new I wondered whether my endo would have seen it. I am due to see him in December and would like to discuss it with him - if it is appropriate to me.

Lilian

Re: For Bob

Hi Lilian,I wonder if Chuck might be able to get a copy for us?It's one of those papers without an abstract and we can't read it without paying a fee.I cannot possibly do that for the number of papers I scan or read.I've been waiting some time to see that particular one, myself.It may be 'released' after 6-12mths.best wishesBob>> Hi Bob,> > You have put in the files "Thyroid Replacement Might Not Be Enough........" but I cannot read it. Is there some way you can tell us what it says or how we can read about it.> > Lilian>------------------------------------TPA is not medically qualified. Consult with a qualified medical practitioner before changing medication.

[Guest guest]

I tried to access this article through uni login but it won't let me see

articles less than one year old. However when you try to access the article, it

comes up with this 'patient access' information (see below). Perhaps if you try

to email the guy below, he might send you a 'patient copy'.

Incidentally the article is just an editorial (not a piece of research) however

as it's published in the same issue as the recent Colin Dayan article, I imagine

that it is talking about Dayan et al's 2009 paper on genes and the need for T3 -

which you can find an abstract of online to show your endo.

PS the info you need to send is.....

W. Kim and C. Bianco

EDITORIAL:For Some, L-Thyroxine Replacement Might Not Be Enough: A Genetic

Rationale

J Clin Endocrinol Metab 2009 94: 1521-1523 doi:10.1210/jc.2009-0410

..................................

Patient Request for Copy of an Article Recently Published by The Endocrine

Society Journals

Please use this request for articles recently published in The Journal of

Clinical Endocrinology & Metabolism, Endocrinology, Molecular Endocrinology, or

Endocrine Reviews.

Note that all articles published more than 12 months ago back to 1997 are free

to all online.

To receive your copy of the requested article, please provide the following

information:

* Article information, including author(s), title of journal, title of

article, issue date and page number. This information is available free online

for all articles in the Table of Contents.

* Your name and e-mail address.

Please e-mail this information to C. Herman at sherman@... so

that the staff at The Endocrine Society can assist you.

[Guest guest]

Oh boy - how we need this one ;o)

Luv - Sheila

I tried to access this article through uni

login but it won't let me see articles less than one year old. However when you

try to access the article, it comes up with this 'patient access' information

(see below). Perhaps if you try to email the guy below, he might send you a

'patient copy'.

Incidentally the article is just an editorial (not a piece of research) however

as it's published in the same issue as the recent Colin Dayan article, I

imagine that it is talking about Dayan et al's 2009 paper on genes and the need

for T3 - which you can find an abstract of online to show your endo.

PS the info you need to send is.....

W. Kim and C. Bianco

EDITORIAL:For Some, L-Thyroxine Replacement Might Not Be Enough: A Genetic

Rationale

J Clin Endocrinol Metab 2009 94: 1521-1523 doi:10.1210/jc.2009-0410

..................................

Patient Request for Copy of an Article Recently Published by The Endocrine

Society Journals

Please use this request for articles recently published in The Journal of

Clinical Endocrinology & Metabolism, Endocrinology, Molecular

Endocrinology, or Endocrine Reviews.

Note that all articles published more than 12 months ago back to 1997 are free

to all online.

To receive your copy of the requested article, please provide the following

information:

* Article information, including author(s), title of journal, title of article,

issue date and page number. This information is available free online for all

articles in the Table of Contents.

* Your name and e-mail address.

Please e-mail this information to C. Herman at sherman@... so that

the staff at The Endocrine Society can assist you.

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21:14:00

[Guest guest]

Bob,

You wrote:

>

> http://jcem.endojournals.org/cgi/content/full/94/5/1521

>

> B. W. Kim and A. C. Bianco

> For Some, L-Thyroxine Replacement Might Not Be Enough: A Genetic Rationale

>

> J. Clin. Endocrinol. Metab., May 1, 2009; 94(5): 1521 - 1523.

Thanks, but since that is an editorial, rather than a paper, there is no

abstract.

The full text is quite controlled, and our library subscription to that journal

expired last April. I could get it only by paying a fee, and then it would be

illegal to share with the list. Sorry.

Chuck

[Guest guest]

Hi Chuck,

many thanks, I tracked down the possible reason that Kim and Bianco were editorialising:-

http://jcem.endojournals.org/cgi/content/abstract/94/9/3521

Thyroid hormone-related regulation of gene expression in human fatty liver

Jussi Pihlajamäki, Tanner Boes, Eun-Young Kim, Farrell Dearie, W. Kim, Schroeder, Mun, Imad Nasser, J. Park, C. Bianco, B. Goldfine and Patti

and also:-

W. Visser, A. Heemstra, Sigrid M. A. Swagemakers, Zeliha Özgür, Eleonora P. Corssmit, us Burggraaf, Wilfred F. J. van Ijcken, J. van der Spek, Johannes W. A. Smit, and Theo J. Visser

Physiological Thyroid Hormone Levels Regulate Numerous Skeletal Muscle Transcripts J Clin Endocrinol Metab 2009 94: 3487-3496 , doi:10.1210/jc.2009-0782 [Abstract] [Full Text] [PDF] [supplemental Data] Skeletal muscle has a major contribution to the metabolic rate in humans; data demonstrate that skeletal muscle transcriptome is largely changed in different thyroid states.

as might be expected, the effects of thyroid hormones in the liver and muscles are significant

best wishes

Bob

> > > > http://jcem.endojournals.org/cgi/content/full/94/5/1521 > > > > B. W. Kim and A. C. Bianco > > For Some, L-Thyroxine Replacement Might Not Be Enough: A Genetic Rationale > > > > J. Clin. Endocrinol. Metab., May 1, 2009; 94(5): 1521 - 1523. > > Thanks, but since that is an editorial, rather than a paper, there is no abstract.> > The full text is quite controlled, and our library subscription to that journal expired last April. I could get it only by paying a fee, and then it would be illegal to share with the list. Sorry.> > Chuck>