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I had my gall bladder removed when I was very young (21) due to stones.

I have been taking 12.5 mg of iodoral for six months, then upped it to 24 mg for

the last six months. Recently I upped it to 36 mg.

I want to do a liver cleanse but I'm worried about what effect not having a gall

bladder will have on that. Should I do something different than someone with a

gall bladder?

I don't think I've had detox symptoms - but I have had weight gain,

irritability, slight depression. I know I am very low in magnesium and I have

been taking 800 mg of magnesium. My blood pressure went down and I feel better

since starting the magnesium, but I think I need more.

What type of detox/cleanse would be best for me?

I also have a B mutation in the MTHFR gene, which I think means I need much more

B vitamins than the average person and it also interferes with mythlation.

Lovely.

Viola

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What I have always read is that you need the liver cleanse MORE when you don't have a gall bladder. (Essentially, a cruddy liver is WHY you lost your gall bladder.)Methyl B12 is supposed to help with methylation, but the problem is that it is hard to absorb. Capsules that you swallow are useless. Most preparations are now sublingual -- sprays that you spray under the tongue, or tablets that you dissolve under the tongue -- the theory being that the nutrient is absorbed through the mucous membranes. (Some preparations are now designed with liposomes or nano-whatevers, to enter the mucous membranes more easily.) You do need to be sure it is the methyl form of B12.AnneOn Feb 28, 2011, at 3:08 AM, Viola wrote: I had my gall bladder removed when I was very young (21) due to stones. I have been taking 12.5 mg of iodoral for six months, then upped it to 24 mg for the last six months. Recently I upped it to 36 mg. I want to do a liver cleanse but I'm worried about what effect not having a gall bladder will have on that. Should I do something different than someone with a gall bladder? I don't think I've had detox symptoms - but I have had weight gain, irritability, slight depression. I know I am very low in magnesium and I have been taking 800 mg of magnesium. My blood pressure went down and I feel better since starting the magnesium, but I think I need more. What type of detox/cleanse would be best for me? I also have a B mutation in the MTHFR gene, which I think means I need much more B vitamins than the average person and it also interferes with mythlation. Lovely. Viola

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Recommend that you read Dr. Loretta Lanphier's article " Living Without A

Gallbadder " :

http://www.oasisadvancedwellness.com/learning/living-without-gallbladder.html.

Her site also has several articles about cleanses or detox that may be of

interest to you. Also read the recent post #71461 on this forum in which Anne

Seals and Dr. L talk about detoxification pathways. Just type that number into

the Message search box.

Weight gain could be considered a detox symptom in that it has often been said

on this forum that if the detox pathways are not working well weight gain may

occur. If one or more of the detox pathways are sluggish or impaired then

irritability will certainly ensue :-)

Some forms of magnesium are better than others ~ magnesium chloride being the

most bioavailable. The general recommendation on this forum is to use topical

magnesium chloride which will bypass the digestive system and be fully available

to the body. You may want to do a search on this forum for 'Dr. Norm Shealy

magnesium' to read other posts I have made about magnesium. Personally I use 2

or 3 different forms of Mg at any given time, the mainstays being topical Mg

chloride, USP grade oral Mg chloride, oral Mg taurate.

The MTFHR mutation generally means that a person would do better to use the

methyl forms of supplementation as their bodies are either poor converters of

some of the B's or do not convert at all. For example a person with MTHFR

issues using B12 as methylcobalamin and using 5-MTHF for folate (B9) would be

best and selenium may be best used as se-methylselenocysteine.

>

> I had my gall bladder removed when I was very young (21) due to stones.

>

> I have been taking 12.5 mg of iodoral for six months, then upped it to 24 mg

for the last six months. Recently I upped it to 36 mg.

>

> I want to do a liver cleanse but I'm worried about what effect not having a

gall bladder will have on that. Should I do something different than someone

with a gall bladder?

>

> I don't think I've had detox symptoms - but I have had weight gain,

irritability, slight depression. I know I am very low in magnesium and I have

been taking 800 mg of magnesium. My blood pressure went down and I feel better

since starting the magnesium, but I think I need more.

>

> What type of detox/cleanse would be best for me?

>

> I also have a B mutation in the MTHFR gene, which I think means I need much

more B vitamins than the average person and it also interferes with mythlation.

>

> Lovely.

>

> Viola

>

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What would make a doctor test for the MTHFR gene mutation?  Are there symptoms that would lead one to suspecting this issue?

 

I will read the article linked below.  Thanks for sharing.  My gall bladder was removed several years ago.  If I had known more then I might have saved it, but I was miserable, with heart attack like pains but on the right side.  Mine was malfunctioning but no stones.

 

Jaxi

On Mon, Feb 28, 2011 at 11:24 AM, baxrox <baxrox@...> wrote:

Recommend that you read Dr. Loretta Lanphier's article " Living Without A Gallbadder " :  http://www.oasisadvancedwellness.com/learning/living-without-gallbladder.html.  Her site also has several articles about cleanses or detox that may be of interest to you.   Also read the recent post #71461 on this forum in which Anne Seals and Dr. L talk about detoxification pathways.  Just type that number into the Message search box.

Weight gain could be considered a detox symptom in that it has often been said on this forum that if the detox pathways are not working well weight gain may occur.  If one or more of the detox pathways are sluggish or impaired then irritability will certainly ensue :-)

Some forms of magnesium are better than others ~ magnesium chloride being the most bioavailable.  The general recommendation on this forum is to use topical magnesium chloride which will bypass the digestive system and be fully available to the body.  You may want to do a search on this forum for 'Dr. Norm Shealy  magnesium' to read other posts I have made about magnesium.  Personally I use 2 or 3 different forms of Mg at any given time, the mainstays being topical Mg chloride, USP grade oral Mg chloride, oral Mg taurate.

The MTFHR mutation generally means that a person would do better to use the methyl forms of supplementation as their bodies are either poor converters of some of the B's or do not convert at all.  For example a person with MTHFR issues using B12 as methylcobalamin and using 5-MTHF for folate (B9) would be best and selenium may be best used as se-methylselenocysteine.

>> I had my gall bladder removed when I was very young (21) due to stones.

>> I have been taking 12.5 mg of iodoral for six months, then upped it to 24 mg for the last six months.  Recently I upped it to 36 mg.>> I want to do a liver cleanse but I'm worried about what effect not having a gall bladder will have on that.  Should I do something different than someone with a gall bladder?

>> I don't think I've had detox symptoms - but I have had weight gain, irritability, slight depression.  I know I am very low in magnesium and I have been taking 800 mg of magnesium.  My blood pressure went down and I feel better since starting the magnesium, but I think I need more.

>> What type of detox/cleanse would be best for me?>> I also have a B mutation in the MTHFR gene, which I think means I need much more B vitamins than the average person and it also interferes with mythlation.

>> Lovely.>> Viola>------------------------------------All off topic posts should go to the IodineOT group  IodineOT/

Commonly asked questions:   http://tinyurl.com/yhnds5e

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what I have is selenomethianine--so that is not the methyl one?

Gracia

The MTFHR mutation generally means that a person would do

better to use the methyl forms of supplementation as their

bodies are either poor converters of some of the B's or do

not convert at all. For example a person with MTHFR issues

using B12 as methylcobalamin and using 5-MTHF for folate

(B9) would be best and selenium may be best used as

se-methylselenocysteine.

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Oh gosh, the answer to that is pretty broad because the methylation pathway is

so extensive. Some of the first things that come to mind are elevated

homocysteine (and related cardiovascular things), clotting issues, history of

miscarriage, autism & /or other autism spectrum disorders, unexplained chronic

illness.

Here is a link to one lab that gives an overview of MTHFR & why to test:

http://www.kimballgenetics.com/tests-mthfr.html (though even LabCorp has this

test)

And here is a link to a pretty good article about the methylation pathway:

http://www.enzymestuff.com/methylation.htm

Dr. Rich Van Konynenburg Ph D has done extensive research about the methylation

pathway as it relates to CFS and glutathione depletion. His simplified protocol

is derived from the more complex approach of Dr. Amy Yasko ND, PhD who works

with autism.

> > >

> > > I had my gall bladder removed when I was very young (21) due to stones.

> > >

> > > I have been taking 12.5 mg of iodoral for six months, then upped it to 24

> > mg for the last six months. Recently I upped it to 36 mg.

> > >

> > > I want to do a liver cleanse but I'm worried about what effect not having

> > a gall bladder will have on that. Should I do something different than

> > someone with a gall bladder?

> > >

> > > I don't think I've had detox symptoms - but I have had weight gain,

> > irritability, slight depression. I know I am very low in magnesium and I

> > have been taking 800 mg of magnesium. My blood pressure went down and I

> > feel better since starting the magnesium, but I think I need more.

> > >

> > > What type of detox/cleanse would be best for me?

> > >

> > > I also have a B mutation in the MTHFR gene, which I think means I need

> > much more B vitamins than the average person and it also interferes with

> > mythlation.

> > >

> > > Lovely.

> > >

> > > Viola

> > >

> >

> >

> >

> >

> > ------------------------------------

> >

> > All off topic posts should go to the IodineOT group

> > IodineOT/

> >

> >

> > Commonly asked questions: http://tinyurl.com/yhnds5e

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According to this abstract (1) L-selenomethionine is a methylated form however I

reckon whether it or L-Se-methylselenocysteine is appropriate may depend on a

person's genetic status ... or ? Perhaps or Dr. L will chime in on

this.

Here is a sales blurb from Life Extension about their L-Se-Methylselenocysteine:

http://www.lifeextensionvitamins.com/noname9.html

Here are a couple of abstrasts on PubMed about L-selenomethionine &

L-Se-Methylselenocysteine:

http://www.ncbi.nlm.nih.gov/pubmed/21261286

http://www.ncbi.nlm.nih.gov/pubmed/21213327

(1) http://www.ncbi.nlm.nih.gov/pubmed/11799920

I have a family member that was consistently low in selenium (via SpectraCell

testing & also RBC) despite aggressive supplementation. Amongst other things I

gave them two forms of selenium equating to 400 mcg daily - one form was

L-Se-Methylselenocysteine. Their selenium levels are now very good and they

continue this approach still today - though I often wonder if they should only

be taking the L-Se-Methylselenocysteine :-)

>

> what I have is selenomethianine--so that is not the methyl one?

> Gracia

> >

> >

> > The MTFHR mutation generally means that a person would do better to

> > use the methyl forms of supplementation as their bodies are either

> > poor converters of some of the B's or do not convert at all. For

> > example a person with MTHFR issues using B12 as methylcobalamin and

> > using 5-MTHF for folate (B9) would be best and selenium may be best

> > used as se-methylselenocysteine.

> >

>

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thanks! I just ordered the life extension one. I am not feeling

good and maybe this will help.

XO

Gracia

On 2/28/2011 3:19 PM, baxrox wrote:

According to this abstract (1) L-selenomethionine is a

methylated form however I reckon whether it or

L-Se-methylselenocysteine is appropriate may depend on a

person's genetic status ... or ? Perhaps or Dr.

L will chime in on this.

Here is a sales blurb from Life Extension about their

L-Se-Methylselenocysteine: http://www.lifeextensionvitamins.com/noname9.html

Here are a couple of abstrasts on PubMed about

L-selenomethionine & L-Se-Methylselenocysteine:

http://www.ncbi.nlm.nih.gov/pubmed/21261286

http://www.ncbi.nlm.nih.gov/pubmed/21213327

(1) http://www.ncbi.nlm.nih.gov/pubmed/11799920

I have a family member that was consistently low in

selenium (via SpectraCell testing & also RBC) despite

aggressive supplementation. Amongst other things I gave

them two forms of selenium equating to 400 mcg daily - one

form was L-Se-Methylselenocysteine. Their selenium levels

are now very good and they continue this approach still

today - though I often wonder if they should only be

taking the L-Se-Methylselenocysteine :-)

>

> what I have is selenomethianine--so that is not the

methyl one?

> Gracia

> >

> >

> > The MTFHR mutation generally means that a person

would do better to

> > use the methyl forms of supplementation as their

bodies are either

> > poor converters of some of the B's or do not

convert at all. For

> > example a person with MTHFR issues using B12 as

methylcobalamin and

> > using 5-MTHF for folate (B9) would be best and

selenium may be best

> > used as se-methylselenocysteine.

> >

>

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I'm thinking that folks with the MTHFR genetic mutation mostly have a blip with

folate metabolism so it is possible that 5-MTHF may solve the problem or most of

the problem.

Though if there are mutations in the MTR or MTRR the cycle will fail with B12

metabolism.

My thought here is that with MTHFR genetic mutation do not overlook the

importance of using 5-MTHF.

Completely agree about using sublingual tablets or sprays of methylcobalamin. I

believe there are also nasal spray applications available if one looks hard

enough.

Methylcobalamin or hydroxocobalamin are the best forms of B12.

>

> > I had my gall bladder removed when I was very young (21) due to

> > stones.

> >

> > I have been taking 12.5 mg of iodoral for six months, then upped it

> > to 24 mg for the last six months. Recently I upped it to 36 mg.

> >

> > I want to do a liver cleanse but I'm worried about what effect not

> > having a gall bladder will have on that. Should I do something

> > different than someone with a gall bladder?

> >

> > I don't think I've had detox symptoms - but I have had weight gain,

> > irritability, slight depression. I know I am very low in magnesium

> > and I have been taking 800 mg of magnesium. My blood pressure went

> > down and I feel better since starting the magnesium, but I think I

> > need more.

> >

> > What type of detox/cleanse would be best for me?

> >

> > I also have a B mutation in the MTHFR gene, which I think means I

> > need much more B vitamins than the average person and it also

> > interferes with mythlation.

> >

> > Lovely.

> >

> > Viola

> >

> >

>

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I believe that the nasal spray also requires a prescription.AnneOn Feb 28, 2011, at 12:31 PM, baxrox wrote: I'm thinking that folks with the MTHFR genetic mutation mostly have a blip with folate metabolism so it is possible that 5-MTHF may solve the problem or most of the problem. Though if there are mutations in the MTR or MTRR the cycle will fail with B12 metabolism. My thought here is that with MTHFR genetic mutation do not overlook the importance of using 5-MTHF. Completely agree about using sublingual tablets or sprays of methylcobalamin. I believe there are also nasal spray applications available if one looks hard enough. Methylcobalamin or hydroxocobalamin are the best forms of B12. > > > I had my gall bladder removed when I was very young (21) due to > > stones. > > > > I have been taking 12.5 mg of iodoral for six months, then upped it > > to 24 mg for the last six months. Recently I upped it to 36 mg. > > > > I want to do a liver cleanse but I'm worried about what effect not > > having a gall bladder will have on that. Should I do something > > different than someone with a gall bladder? > > > > I don't think I've had detox symptoms - but I have had weight gain, > > irritability, slight depression. I know I am very low in magnesium > > and I have been taking 800 mg of magnesium. My blood pressure went > > down and I feel better since starting the magnesium, but I think I > > need more. > > > > What type of detox/cleanse would be best for me? > > > > I also have a B mutation in the MTHFR gene, which I think means I > > need much more B vitamins than the average person and it also > > interferes with mythlation. > > > > Lovely. > > > > Viola > > > > >

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Not really. You can purchase them through Iherb. No presc. required.AyseOn Mon, Feb 28, 2011 at 10:52 PM, Anne Seals <anneseals@...> wrote:

 

I believe that the nasal spray also requires a prescription.AnneOn Feb 28, 2011, at 12:31 PM, baxrox wrote:

  I'm thinking that folks with the MTHFR genetic mutation mostly have a blip with folate metabolism so it is possible that 5-MTHF may solve the problem or most of the problem. Though if there are mutations in the MTR or MTRR the cycle will fail with B12 metabolism.

My thought here is that with MTHFR genetic mutation do not overlook the importance of using 5-MTHF. Completely agree about using sublingual tablets or sprays of methylcobalamin. I believe there are also nasal spray applications available if one looks hard enough.

Methylcobalamin or hydroxocobalamin are the best forms of B12. > > > I had my gall bladder removed when I was very young (21) due to

> > stones. > > > > I have been taking 12.5 mg of iodoral for six months, then upped it > > to 24 mg for the last six months. Recently I upped it to 36 mg. > > > > I want to do a liver cleanse but I'm worried about what effect not

> > having a gall bladder will have on that. Should I do something > > different than someone with a gall bladder? > > > > I don't think I've had detox symptoms - but I have had weight gain,

> > irritability, slight depression. I know I am very low in magnesium > > and I have been taking 800 mg of magnesium. My blood pressure went > > down and I feel better since starting the magnesium, but I think I

> > need more. > > > > What type of detox/cleanse would be best for me? > > > > I also have a B mutation in the MTHFR gene, which I think means I > > need much more B vitamins than the average person and it also

> > interferes with mythlation. > > > > Lovely. > > > > Viola > > > > >

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