iodine alone vs iodide/iodine combo in breast cancer

[Guest guest]

I'm doing some digging today and came across this. Sorry, if it is old news.

It dates back to 2008.

" Our data in figure 1 shows that at 48 hours, 1 mM iodine/iodide had no effect

on cell proliferation or viability, relative to control cells. However,

treatment with 5 mM iodine/iodide was toxic to the cells, inhibiting cell

proliferation and reducing cell viability to less than 5% of control cells "

" Interestingly, it has been reported that iodine alone can induce apoptosis at

concentrations as low as 1µM [14], however we did not see cytotoxicity even at

significantly higher (1mM) doses. "

" Finally, since previous studies have all used iodine alone while we used a

combination of iodine and iodide, it is possible that the presence of iodide

protects the MCF-7 cells from the detrimental effects of iodine. Indeed, it has

been reported that iodide up to 5mM did not have a cytotoxic effect on MCF-7

cells [14]. Furthermore, this may explain why breast cancers, which have

increased NIS expression [17, 18] and increased iodide [18] uptake do not

undergo apoptosis. "

http://www.medsci.org/v05p0189.htm

Joan