Re: Aspirin desensitization failure - apparently - with bad results

[Guest guest]

I did get worse on 1300 mg of aspirin after being desensitized and developed pretty bad asthma, which I hadn’t had. I cut down to 650 mg/ day and then did better and now am fine on that does. But I didn’t get to the point you did, and hadn’t had much asthma before.On Apr 26, 2011, at 12:49 PM, philget wrote:

I posted a while ago about having a bad asthma attack about a week after being desensitized. I was put on Zyflo and Singulair and continued taking 1300 mg of aspirin a day in the hope that it would eventually benefit me. Four days ago I had the worst attack of my life, passed out, turned blue, etc. Fortunately someone called an ambulance and the EMTs and ER staff got me going again. Neither I nor my doctor knows why this happened. I took the aspirin faithfully every day but I guess my body decided on its own to become resensitized. Or it could have been a coincidence. But this seems unlikely since I haven't had a bad attack in years. I found one case report in the literature of a patient who spontaneously became resensitized to aspirin. But it is, as far as I know unheard of except for that instance. I've stopped the aspirin. I hope this doesn't frighten someone who would benefit from desensitization. It seems to help a lot of people. Maybe I did something wrong.

Feedback?

[Guest guest]

Did they check your blood eosinophil levels while on desensitization, to make

sure it remained within reasonable bounds ?

>

> I posted a while ago about having a bad asthma attack about a week after being

desensitized. I was put on Zyflo and Singulair and continued taking 1300 mg of

aspirin a day in the hope that it would eventually benefit me. Four days ago I

had the worst attack of my life, passed out, turned blue, etc. Fortunately

someone called an ambulance and the EMTs and ER staff got me going again.

Neither I nor my doctor knows why this happened. I took the aspirin faithfully

every day but I guess my body decided on its own to become resensitized. Or it

could have been a coincidence. But this seems unlikely since I haven't had a bad

attack in years. I found one case report in the literature of a patient who

spontaneously became resensitized to aspirin. But it is, as far as I know

unheard of except for that instance. I've stopped the aspirin. I hope this

doesn't frighten someone who would benefit from desensitization. It seems to

help a lot of people. Maybe I did something wrong. Feedback?

>

[Guest guest]

Is it possible the asthma attack had othing to do with aspirin? Occasionally I get a mild asthma attack, and I can usually put it down to having had either a curry in the past 12 hours or some wine (only a small amount - sometimes i'm totally fine, and sometimes I'm not) or bad stress. I have been desens to aspirin now for 3+ years and gone off it twice and been redesens twice (due to 2 seperate operatrions) .

That must have been very scary for you and those close to you. I hope it never happens again.

Best wishes

Becky

From: joan harvey <thomyris7@...>samters Sent: Tue, 26 April, 2011 20:21:30Subject: Re: Aspirin desensitization failure - apparently - with bad results

I did get worse on 1300 mg of aspirin after being desensitized and developed pretty bad asthma, which I hadn’t had. I cut down to 650 mg/ day and then did better and now am fine on that does. But I didn’t get to the point you did, and hadn’t had much asthma before.

On Apr 26, 2011, at 12:49 PM, philget wrote:

I posted a while ago about having a bad asthma attack about a week after being desensitized. I was put on Zyflo and Singulair and continued taking 1300 mg of aspirin a day in the hope that it would eventually benefit me. Four days ago I had the worst attack of my life, passed out, turned blue, etc. Fortunately someone called an ambulance and the EMTs and ER staff got me going again. Neither I nor my doctor knows why this happened. I took the aspirin faithfully every day but I guess my body decided on its own to become resensitized. Or it could have been a coincidence. But this seems unlikely since I haven't had a bad attack in years. I found one case report in the literature of a patient who spontaneously became resensitized to aspirin. But it is, as far as I know unheard of except for that instance. I've stopped the aspirin. I hope this doesn't frighten someone who would benefit from desensitization. It seems to help a lot of people. Maybe I did

something wrong. Feedback?

[Guest guest]

Asfy,

I don't know anything about blood eosinophil levels as they relate to

desensitization. I think I understand that they play a big role in asthma. I

know they go up when I stop prednisone, down when I take it. How do they affect

the desense process and the likelihood of problems later on? Thanks!

>

> Did they check your blood eosinophil levels while on desensitization, to make

sure it remained within reasonable bounds ?

> >

>

[Guest guest]

Joan,

Thanks for sharing that. Your experience was a lot different than what my doc

led me to expect. I was told that, once I could take my threshold dose without a

reaction, I could take any amount of aspirin without a reaction. I wonder if

there are other people who can tolerate lower doses but not higher doses after

desensitization? It might be a good thing for a doc who does the procedure to

know!

>

> I did get worse on 1300 mg of aspirin after being desensitized and developed

pretty bad asthma, which I hadn't had. I cut down to 650 mg/ day and then did

better and now am fine on that does. But I didn't get to the point you did, and

hadn't had much asthma before.

[Guest guest]

> From: Crusher Miler <crusher75060@...>

> Back 15 or more years ago I reacted at 20 mg (1/4 baby aspirin). After the

> second day I was up to 1 regular aspirin or 325 mg. That was what I was

> supposed to take daily. Seems low compared to everyone else in here.

>  

325mg, or probably even 81mg, is enough to stay desensitized, but may not

achieve the reduction of symptoms that larger doses will.

[Guest guest]

For an example of this possibility, see post #13860.

> >

> > Did they check your blood eosinophil levels while on desensitization, to

make sure it remained within reasonable bounds ?

> > >

> >

>

[Guest guest]

I read the referenced post. If I read it right, it was: that individual

experienced increased blood eosinophil levels after aspirin desent? My

experience with samters was one primarly of uncontrolled asthma, sure I have no

sense of smell and my sinuses where totally occluded, but It was my asthma that

was making life difficult. After desent my ENT felt that the polpy growth slowed

but my asthma was about the same, requiring prednisone taper every 4-6 weeks.

Zyflo CR has finally stablized my asthma however.

Question:

Do most people after desent experience no, little, or worstening of their asthma

but stablization of polyp growth?

Does anyone know the significance of increased blood eosinophil levels to polyps

or asthma? Is it relevant to asthma and not polyps?

> > >

> > > Did they check your blood eosinophil levels while on desensitization, to

make sure it remained within reasonable bounds ?

> > > >

> > >

> >

>

[Guest guest]

I also had very high eosinophil levels post desense. Seem to have gotten them under control, first with steroids and antibiotics, then with lots of Vit D, fish oil, chinese herbs and acupuncture.On Apr 28, 2011, at 5:54 PM, damianodavid wrote:

I read the referenced post. If I read it right, it was: that individual experienced increased blood eosinophil levels after aspirin desent? My experience with samters was one primarly of uncontrolled asthma, sure I have no sense of smell and my sinuses where totally occluded, but It was my asthma that was making life difficult. After desent my ENT felt that the polpy growth slowed but my asthma was about the same, requiring prednisone taper every 4-6 weeks. Zyflo CR has finally stablized my asthma however.

Question:

Do most people after desent experience no, little, or worstening of their asthma but stablization of polyp growth?

Does anyone know the significance of increased blood eosinophil levels to polyps or asthma? Is it relevant to asthma and not polyps?

> > >

> > > Did they check your blood eosinophil levels while on desensitization, to make sure it remained within reasonable bounds ?

> > > >

> > >

> >

>

[Guest guest]

,

eosinophils are relevant to both asthma and nasal polyps ; high eosinophil

levels lead to severe asthma and fast-growing polyps. Locally, polyp tissue

generally shows high eosinophil levels.

> > > >

> > > > Did they check your blood eosinophil levels while on desensitization, to

make sure it remained within reasonable bounds ?

> > > > >

> > > >

> > >

> >

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