Panax Ginseng might be useful in asthma

[Guest guest]

J Ethnopharmacol. 2011 Apr 28. [Epub ahead of print]Panax ginseng ameliorates airway inflammation in an ovalbumin-sensitized mouse allergic asthma model.Kim DY, Yang WM.SourceDepartment of Pharmacology, Sungkyunkwan University School of Medicine, 300 Chunchun-dong, Jangan-ku, Suwon 440-746, Republic of Korea.AbstractAIM OF THE STUDY:Panax ginseng (PG) is a medicinal herb that has been used to treat various immune diseases including asthma and COPD. In this study, we investigated the inhibitory mechanism of PG on asthma parameters in mice.MATERIALS AND METHODS:BALB/c mice were sensitized with 20μg/200μl OVA adsorbed on 1.0mg/50μl aluminum hydroxide gel adjuvant by i.p. injection on days 0 and 14. Mice were then challenged with 5% OVA in PBS to the nose for 30min once a day for 3 days, from day 20 until day 22, using a nebulizer. PG (20mg/kg) or vehicle was administrated by i.p. injection once a day 10min before every OVA challenge for 3 days. The recruitment of inflammatory cells into bronchoalveolar lavage fluid or lung tissues was measured. The expression of EMBP, Muc5ac, CD40, and CD40 ligand (CD40L) in lung tissues was investigated. In addition, the cytokines and mitogen activated protein (MAP) kinases were measured by RT-PCR and Western blot.RESULTS AND CONCLUSIONS:PG restored the expression of EMBP, Muc5ac, CD40, and CD40L, as well as the mRNA and protein levels of interleukin (IL)-1β, IL-4, IL-5, and tumor necrosis factor (TNF)-α. In addition, PG inhibited the numbers of goblet cells and further small G proteins and MAP kinases in bronchoalveolar lavage cells and lung tissues increased in ovalbumin-induced allergic asthma in mice. These results suggest that PG may be used as a therapeutic agent in asthma, based on reductions of various allergic responses.

[Guest guest]

Hi Asfy.It only makes sense that some plant compounds can influence inate

immunity since the inate immune system itself is derived from plant based

immunity.Dr. Desrosiers also suggested I might take ginseng on my last visit.

Sincerely Wayne

>

> J Ethnopharmacol. <http://www.ncbi.nlm.nih.gov/pubmed/21549818> 2011

> Apr 28. [Epub ahead of print]Panax ginseng ameliorates airway

> inflammation in an ovalbumin-sensitized mouse allergic asthma model.Kim

> DY <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Kim%20DY%22%5BAuthor%5D>

> , Yang WM

> <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Yang%20WM%22%5BAuthor%5D>

> .Source

> Department of Pharmacology, Sungkyunkwan University School of Medicine,

> 300 Chunchun-dong, Jangan-ku, Suwon 440-746, Republic of Korea.

> AbstractAIM OF THE STUDY:

> Panax ginseng (PG) is a medicinal herb that has been used to treat

> various immune diseases including asthma and COPD. In this study, we

> investigated the inhibitory mechanism of PG on asthma parameters in

> mice.

> MATERIALS AND METHODS:

> BALB/c mice were sensitized with 20μg/200μl OVA adsorbed on

> 1.0mg/50μl aluminum hydroxide gel adjuvant by i.p. injection on days

> 0 and 14. Mice were then challenged with 5% OVA in PBS to the nose for

> 30min once a day for 3 days, from day 20 until day 22, using a

> nebulizer. PG (20mg/kg) or vehicle was administrated by i.p. injection

> once a day 10min before every OVA challenge for 3 days. The recruitment

> of inflammatory cells into bronchoalveolar lavage fluid or lung tissues

> was measured. The expression of EMBP, Muc5ac, CD40, and CD40 ligand

> (CD40L) in lung tissues was investigated. In addition, the cytokines and

> mitogen activated protein (MAP) kinases were measured by RT-PCR and

> Western blot.

> RESULTS AND CONCLUSIONS:

> PG restored the expression of EMBP, Muc5ac, CD40, and CD40L, as well as

> the mRNA and protein levels of interleukin (IL)-1β, IL-4, IL-5, and

> tumor necrosis factor (TNF)-α. In addition, PG inhibited the numbers

> of goblet cells and further small G proteins and MAP kinases in

> bronchoalveolar lavage cells and lung tissues increased in

> ovalbumin-induced allergic asthma in mice. These results suggest that PG

> may be used as a therapeutic agent in asthma, based on reductions of

> various allergic responses.

>

[Guest guest]

Hi Wayne,

I have been trying Panax GInseng lately and can say it is safe. In fact, it may

lessen inflammation. At any rate, it is a mild stimulant and helps work.

> >

> > J Ethnopharmacol. <http://www.ncbi.nlm.nih.gov/pubmed/21549818> 2011

> > Apr 28. [Epub ahead of print]Panax ginseng ameliorates airway

> > inflammation in an ovalbumin-sensitized mouse allergic asthma model.Kim

> > DY <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Kim%20DY%22%5BAuthor%5D>

> > , Yang WM

> > <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Yang%20WM%22%5BAuthor%5D>

> > .Source

> > Department of Pharmacology, Sungkyunkwan University School of Medicine,

> > 300 Chunchun-dong, Jangan-ku, Suwon 440-746, Republic of Korea.

> > AbstractAIM OF THE STUDY:

> > Panax ginseng (PG) is a medicinal herb that has been used to treat

> > various immune diseases including asthma and COPD. In this study, we

> > investigated the inhibitory mechanism of PG on asthma parameters in

> > mice.

> > MATERIALS AND METHODS:

> > BALB/c mice were sensitized with 20μg/200μl OVA adsorbed on

> > 1.0mg/50μl aluminum hydroxide gel adjuvant by i.p. injection on days

> > 0 and 14. Mice were then challenged with 5% OVA in PBS to the nose for

> > 30min once a day for 3 days, from day 20 until day 22, using a

> > nebulizer. PG (20mg/kg) or vehicle was administrated by i.p. injection

> > once a day 10min before every OVA challenge for 3 days. The recruitment

> > of inflammatory cells into bronchoalveolar lavage fluid or lung tissues

> > was measured. The expression of EMBP, Muc5ac, CD40, and CD40 ligand

> > (CD40L) in lung tissues was investigated. In addition, the cytokines and

> > mitogen activated protein (MAP) kinases were measured by RT-PCR and

> > Western blot.

> > RESULTS AND CONCLUSIONS:

> > PG restored the expression of EMBP, Muc5ac, CD40, and CD40L, as well as

> > the mRNA and protein levels of interleukin (IL)-1β, IL-4, IL-5, and

> > tumor necrosis factor (TNF)-α. In addition, PG inhibited the numbers

> > of goblet cells and further small G proteins and MAP kinases in

> > bronchoalveolar lavage cells and lung tissues increased in

> > ovalbumin-induced allergic asthma in mice. These results suggest that PG

> > may be used as a therapeutic agent in asthma, based on reductions of

> > various allergic responses.

> >

>