Guest guest Posted January 24, 2006 Report Share Posted January 24, 2006 Mike, I hope you will consult your dr. about the bleeding. It's worth checking out. When I initially went up to 1300/day, I developed heartburn. I then switched to enteric aspirin and have not had a problem since (2 years). I take two with breakfast and one or two with dinner. I have been careful to be on the alert and have not had any bleeding. Many people with arthritis and other chronic pain have taken more than 1300/day for years. Other than the gastric problems, I have not read of any significant proven dangers with this dosage. If anyone has any references of studies showing problems, I would like to see them. Regarding desens, I was told at Scripps that they had seen some individuals who suffered severe reaction to only 5mg! Until you try aspirin, you really don't know where/how you will react. I would assume, like other " real " allergies, that your reaction threshold could change over time. I reacted to 63mg, but I've never had severe reactions to aspirin. Jim (Tx) > > I'm just curious to those who have done aspirin: How bad did your GI > problems get, and when was enough enough? > > I'm on 1300 and my stomach's just been generally ooky for the whole month so > far, but not bad enough to turn back. I've been taking about 1 prilosec a > day. Yesterday there was some evidence of intestinal bleeding (I'll spare > you the details), but it looked as though the trouble was very low in the > tract and it wasn't particularly painful. It's cleared up since then. > > But obviously that's kinda scary. I'm thinking of doubling the prilosec and, > if I see blood again, halving the aspirin. I wish there were some numbers > on the efficacy of lower aspirin doses though. 1300 is an awful lot. My > allergist, who is pretty well versed in aspirin sensitivity, was shocked > when I told him that's what son's protocol used, and said eventually > most people would " bleed out " on that. > > > - > Mike > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 24, 2006 Report Share Posted January 24, 2006 ok if you dont mind and can remember. take me through your doses and when they were given to you from the time you arrived up until you got to go home from your desens. thanks. -- In samters , " Jim Brown " <jim747@s...> wrote: > > > Mike, > > I hope you will consult your dr. about the bleeding. It's worth > checking out. > > When I initially went up to 1300/day, I developed heartburn. I then > switched to enteric aspirin and have not had a problem since (2 > years). I take two with breakfast and one or two with dinner. I have > been careful to be on the alert and have not had any bleeding. Many > people with arthritis and other chronic pain have taken more than > 1300/day for years. Other than the gastric problems, I have not read > of any significant proven dangers with this dosage. If anyone has > any references of studies showing problems, I would like to see them. > > Regarding desens, I was told at Scripps that they had seen some > individuals who suffered severe reaction to only 5mg! Until you try > aspirin, you really don't know where/how you will react. I would > assume, like other " real " allergies, that your reaction threshold > could change over time. I reacted to 63mg, but I've never had severe > reactions to aspirin. > > Jim (Tx) > > > > > > > > > > > > I'm just curious to those who have done aspirin: How bad did your > GI > > problems get, and when was enough enough? > > > > I'm on 1300 and my stomach's just been generally ooky for the > whole month so > > far, but not bad enough to turn back. I've been taking about 1 > prilosec a > > day. Yesterday there was some evidence of intestinal bleeding > (I'll spare > > you the details), but it looked as though the trouble was very low > in the > > tract and it wasn't particularly painful. It's cleared up since > then. > > > > But obviously that's kinda scary. I'm thinking of doubling the > prilosec and, > > if I see blood again, halving the aspirin. I wish there were some > numbers > > on the efficacy of lower aspirin doses though. 1300 is an awful > lot. My > > allergist, who is pretty well versed in aspirin sensitivity, was > shocked > > when I told him that's what son's protocol used, and said > eventually > > most people would " bleed out " on that. > > > > > > - > > Mike > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 24, 2006 Report Share Posted January 24, 2006 Well I did it from home, it was just, first day: 20, 40, 60 (reaction), then 80 the next day, over the course of the day, then I doubled it each day until I was at 1300. I also tried to increase the proximity of doses, so if the first day I had them over the course of 12 hours, on the second day, I grouped 40 within an hour, then another 40 later in the day. That's slower than they do it at scripps i think, but I had some pretty big polyps bangin' around in there, and I was doing it from home, so I erred on the side of caution. I'd love to hear more specifics from people who went through scripps, if they remember.On 1/24/06, tex22_us < tex22_us@...> wrote:ok if you dont mind and can remember. take me through your doses and when they were given to you from the time you arrived up until yougot to go home from your desens. thanks.-- In samters , " Jim Brown " <jim747@s...> wrote:>>> Mike,>> I hope you will consult your dr. about the bleeding. It's worth> checking out.>> When I initially went up to 1300/day, I developed heartburn. I then > switched to enteric aspirin and have not had a problem since (2> years). I take two with breakfast and one or two with dinner. Ihave> been careful to be on the alert and have not had any bleeding. Many > people with arthritis and other chronic pain have taken more than> 1300/day for years. Other than the gastric problems, I have notread> of any significant proven dangers with this dosage. If anyone has > any references of studies showing problems, I would like to seethem.>> Regarding desens, I was told at Scripps that they had seen some> individuals who suffered severe reaction to only 5mg! Until you try > aspirin, you really don't know where/how you will react. I would> assume, like other " real " allergies, that your reaction threshold> could change over time. I reacted to 63mg, but I've never had severe> reactions to aspirin.>> Jim (Tx)>>>>>>>> > >> > I'm just curious to those who have done aspirin: How bad didyour> GI> > problems get, and when was enough enough?> >> > I'm on 1300 and my stomach's just been generally ooky for the > whole month so> > far, but not bad enough to turn back. I've been taking about 1> prilosec a> > day. Yesterday there was some evidence of intestinal bleeding> (I'll spare> > you the details), but it looked as though the trouble was very low> in the> > tract and it wasn't particularly painful. It's cleared up since> then.> >> > But obviously that's kinda scary. I'm thinking of doubling the> prilosec and, > > if I see blood again, halving the aspirin. I wish there weresome> numbers> > on the efficacy of lower aspirin doses though. 1300 is an awful> lot. My> > allergist, who is pretty well versed in aspirin sensitivity, was > shocked> > when I told him that's what son's protocol used, and said> eventually> > most people would " bleed out " on that.> >> >> > -> > Mike > >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 24, 2006 Report Share Posted January 24, 2006 Jim, (or anyone else) did your doctor suggest anything specific to watch for w/r/t GI irritation? I will definitely contact the doctor if this happens again, and I've doubled my prilosec already. On 1/24/06, Condouris <condour@...> wrote: Well I did it from home, it was just, first day: 20, 40, 60 (reaction), then 80 the next day, over the course of the day, then I doubled it each day until I was at 1300. I also tried to increase the proximity of doses, so if the first day I had them over the course of 12 hours, on the second day, I grouped 40 within an hour, then another 40 later in the day. That's slower than they do it at scripps i think, but I had some pretty big polyps bangin' around in there, and I was doing it from home, so I erred on the side of caution. I'd love to hear more specifics from people who went through scripps, if they remember.On 1/24/06, tex22_us < tex22_us@...> wrote:ok if you dont mind and can remember. take me through your doses and when they were given to you from the time you arrived up until yougot to go home from your desens. thanks.-- In samters , " Jim Brown " <jim747@s...> wrote:>>> Mike,>> I hope you will consult your dr. about the bleeding. It's worth> checking out.>> When I initially went up to 1300/day, I developed heartburn. I then > switched to enteric aspirin and have not had a problem since (2> years). I take two with breakfast and one or two with dinner. Ihave> been careful to be on the alert and have not had any bleeding. Many > people with arthritis and other chronic pain have taken more than> 1300/day for years. Other than the gastric problems, I have notread> of any significant proven dangers with this dosage. If anyone has > any references of studies showing problems, I would like to seethem.>> Regarding desens, I was told at Scripps that they had seen some> individuals who suffered severe reaction to only 5mg! Until you try > aspirin, you really don't know where/how you will react. I would> assume, like other " real " allergies, that your reaction threshold> could change over time. I reacted to 63mg, but I've never had severe> reactions to aspirin.>> Jim (Tx)>>>>>>>> > >> > I'm just curious to those who have done aspirin: How bad didyour> GI> > problems get, and when was enough enough?> >> > I'm on 1300 and my stomach's just been generally ooky for the > whole month so> > far, but not bad enough to turn back. I've been taking about 1> prilosec a> > day. Yesterday there was some evidence of intestinal bleeding> (I'll spare> > you the details), but it looked as though the trouble was very low> in the> > tract and it wasn't particularly painful. It's cleared up since> then.> >> > But obviously that's kinda scary. I'm thinking of doubling the> prilosec and, > > if I see blood again, halving the aspirin. I wish there weresome> numbers> > on the efficacy of lower aspirin doses though. 1300 is an awful> lot. My> > allergist, who is pretty well versed in aspirin sensitivity, was > shocked> > when I told him that's what son's protocol used, and said> eventually> > most people would " bleed out " on that.> >> >> > -> > Mike > >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 24, 2006 Report Share Posted January 24, 2006 Sorry, but I don't remember. Actually, I'm not sure I was told. I checked into Scripps on a Sunday evening and checked out Thurs. morning. They gave me pills every four hours or so and checked my breathing, etc. It was a scientific study and what they gave me (and how much) was not revealed at the time. At Dr. son's request, I allowed them to test me with Vioxx as part of his ongoing study. He told me later that I, along with 170 previous samterites, did not react to Vioxx. That test was, of course, done before they started giving me aspirin. Jim > > > > > > I'm just curious to those who have done aspirin: How bad did > your > > GI > > > problems get, and when was enough enough? > > > > > > I'm on 1300 and my stomach's just been generally ooky for the > > whole month so > > > far, but not bad enough to turn back. I've been taking about 1 > > prilosec a > > > day. Yesterday there was some evidence of intestinal bleeding > > (I'll spare > > > you the details), but it looked as though the trouble was very > low > > in the > > > tract and it wasn't particularly painful. It's cleared up since > > then. > > > > > > But obviously that's kinda scary. I'm thinking of doubling the > > prilosec and, > > > if I see blood again, halving the aspirin. I wish there were > some > > numbers > > > on the efficacy of lower aspirin doses though. 1300 is an awful > > lot. My > > > allergist, who is pretty well versed in aspirin sensitivity, was > > shocked > > > when I told him that's what son's protocol used, and said > > eventually > > > most people would " bleed out " on that. > > > > > > > > > - > > > Mike > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 24, 2006 Report Share Posted January 24, 2006 My doctor really didn't give me any specifics to look for. My gastric symptoms were just acid reflux and a burning sensation in my lower esophagus. Nexium didn't get rid of it by itself (I had been already taking it for acid reflux). I had to take some Maalox for a week or so before it stopped. As far as internal bleeding, I assume that the hemocult or other tests that look for blood in the stool are the best way to check. Also, I would think that typical blood tests would show anemia if you are bleeding internally. Since going on aspirin, I have not noticed any increased tendency to bleed or bruise. I have heard, mainly from news reports, that you should wean yourself gradually if you decide to discontinue aspirin. Apparently there may be a higher risk of clotting (heart attack), if you stop taking it abruptly after being on aspirin for an extended time. I'm not sure if this has been confirmed by research. Jim > > > > > > > > > > I'm just curious to those who have done aspirin: How bad did > > > your > > > > GI > > > > > problems get, and when was enough enough? > > > > > > > > > > I'm on 1300 and my stomach's just been generally ooky for the > > > > whole month so > > > > > far, but not bad enough to turn back. I've been taking about 1 > > > > prilosec a > > > > > day. Yesterday there was some evidence of intestinal bleeding > > > > (I'll spare > > > > > you the details), but it looked as though the trouble was very > > > low > > > > in the > > > > > tract and it wasn't particularly painful. It's cleared up since > > > > then. > > > > > > > > > > But obviously that's kinda scary. I'm thinking of doubling the > > > > prilosec and, > > > > > if I see blood again, halving the aspirin. I wish there were > > > some > > > > numbers > > > > > on the efficacy of lower aspirin doses though. 1300 is an awful > > > > lot. My > > > > > allergist, who is pretty well versed in aspirin sensitivity, was > > > > shocked > > > > > when I told him that's what son's protocol used, and said > > > > eventually > > > > > most people would " bleed out " on that. > > > > > > > > > > > > > > > - > > > > > Mike > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 24, 2006 Report Share Posted January 24, 2006 I couldn't remember the numbers but I knew I posted a report at the time. You can look it up, it is message #3756. I don't think the gin part of the recipe was a good idea in retrospect. I would use Alka-Seltzer next time. You should search the posts, there is a lot of good info hidden en the previous years. Good Luck, Pam On 1/24/06 12:58 PM, " tex22_us " <tex22_us@...> wrote: > ok if you dont mind and can remember. take me through your doses and > when they were given to you from the time you arrived up until you > got to go home from your desens. thanks. > -- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 24, 2006 Report Share Posted January 24, 2006 My doctor told me to stop taking the aspirin and go to the hospital if I get a strong pain in the bottom of my stomach (the top of my belly). He said it is possible to get an ulcer at the entrance to the intestines where the enteric aspirin dissolves. I have had no problems with aspirin or my GI tract and I take 1300 at once with dinner now. On 1/24/06 2:01 PM, " Condouris " <condour@...> wrote: Jim, (or anyone else) did your doctor suggest anything specific to watch for w/r/t GI irritation? I will definitely contact the doctor if this happens again, and I've doubled my prilosec already. -- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 24, 2006 Report Share Posted January 24, 2006 thank you so much! i really appreiciate the information. In samters , Pamela <pam@n...> wrote: > > I couldn't remember the numbers but I knew I posted a report at the time. > You can look it up, it is message #3756. I don't think the gin part of the > recipe was a good idea in retrospect. I would use Alka-Seltzer next time. > You should search the posts, there is a lot of good info hidden en the > previous years. > > Good Luck, > > Pam > > > On 1/24/06 12:58 PM, " tex22_us " <tex22_us@y...> wrote: > > > ok if you dont mind and can remember. take me through your doses and > > when they were given to you from the time you arrived up until you > > got to go home from your desens. thanks. > > > > -- > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 25, 2006 Report Share Posted January 25, 2006 pamela, are you still on the 325mg twice a day for maintenance? thanks. > > > ok if you dont mind and can remember. take me through your doses and > > when they were given to you from the time you arrived up until you > > got to go home from your desens. thanks. > > > > -- > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 25, 2006 Report Share Posted January 25, 2006 , Would love to know where your allergist gets his data and when he says eventually bleed out, how long is eventually. I am not saying aspirin does not cause bleeding problems in some people (of course it does), but just I would like to know what data he is citing. All NSAIDs can cause GI bleeding, not just aspirin, and there are people who take really high doses of other NSAIDs besides aspirin for years and years for other conditions such as severe arthritis. I was on 1300 milligrams every day for seven years and never had any GI problems from the aspirin. I took it always with a full meal (not just a snack) and always took Ascriptin. I realize that this will not eliminate the bleeding problems or other GI problems from aspirin, because it works through the bloodstream on the platlets and it's just not at the point of absorption where it causes problems. But this is my experience. I am not saying that no one will have GI problems on it, but it is possible to go for as long as seven years without GI problems. There is information on the 650 dose. Scripps sent out information to participants from the study a couple of years ago that said that some participants were able to have symptom improvement on 650 a day, and they recommended that people try 650 a day and if they experienced symptom worsening they could return to 1300 a day. Hope this helps. Of course if you are having recurrent GI bleeding, you have to be cautious. Maybe you could reduce the dose to a smaller amount for a while to stay desensitized but let your GI tract heal if there was bleeding. Lori Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 25, 2006 Report Share Posted January 25, 2006 Please, I stress again, be careful with this. This is not only a science, it is an art. First of all, when I was at Scripps, they did not tell me the doses I was getting. Second of all, they had special preparations that are not commercially available. Thirdly, it would not be exactly the same for each person, it would really vary based on your reactions. I almost died twice taking aspirin/NSAIDs before I knew I was allergic/sensitive. Please be wise about this. Lori Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 25, 2006 Report Share Posted January 25, 2006 The one thing I will say about the procedure at Scripps is they give you one dose, you react. Then they give you that dose again and you probably do not react are desensitized to that dose apparently. Then they give you a higher dose until you react, and then you get the same one again. I don't know how many days yours lasted, , but the Scripps one can be 5-10 days. Lori Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 26, 2006 Report Share Posted January 26, 2006 On the issue of the " bleedout " ... he was definitely saying this in a fast and loose way, just that it was a risk. Which I suppose is true.And yes I should also stress that I can't recommend doing this on your own. Everyone reacts differnently. But I felt it was necessary to share my experience and seek group advice and experiences as well. My doc, for the record, wasn't too happy that I had done it myself either. It took me around 5 days to ramp up to 325, I think. I took my time with it.I haven't had a repeat of any GI problems yet. My stomach is just continuously a bit sour. I've switched between enteric and alka-seltzer to see if there's a significant difference, and the enteric is certainly a little easier on the stomach but I worry just as much about points south. I may go down to 650 after another month if my stomach remains a little queasy, and of course if it gets worse I'll certainly do so. On 1/25/06, truelori <lori@...> wrote: The one thing I will say about the procedure at Scripps is they giveyou one dose, you react. Then they give you that dose again and youprobably do not react are desensitized to that dose apparently. Thenthey give you a higher dose until you react, and then you get the same one again.I don't know how many days yours lasted, , but the Scripps onecan be 5-10 days.Lori Quote Link to comment Share on other sites More sharing options...
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