Re: Leukotrienes and aortic stenosis

[Guest guest]

>

> Aortic stenosis is a cause of sudden death.Read this today in Science daily

from the journal Circulation. " Inflammation behind heart valve

disease " Mar16,2011.A group of immune cells and leukotrienes found in calcified

heart valves.Statins capable of preventing arteriosclerosis but ineffective in

preventing calcification of the aortic valve.Anti-inflammatories could be a

future treatment.I need to know which group of immune cells is involved and if

there is any relation to this and calcifying sinuses?Sincerely Wayne

>

Found this paper and here are a few exerpts; " Apparently inflammatory

infiltration of activated macrophages and T-cells as well as cytokine release

has been described in human aortic valves. "

" LT's exert there effects by activating BLT1 and BLT2 receptors(BLT2R),the high

and low affinity receptors for LTB4,respectively,and cysteinyl LT1 (CysT1)and

CysLT2receptors for Leukotriene C4(LTC4).D4 and E4.These LT receptors are

expressed on inflammatory cells such as macrophages,lymphocytes,and

granulocytes,and on structural cells within the vascular and airway walls. "

" Despite beneficial effects of anti-LT's in experimental arteriosclerosis ,no

study has explored the role of ant-LT's in aortic stenosis "

" LTC-4-Induced effects in human valvular myofibroblasts....Exposure of

myofibroblasts to LTC4caused a significant rise in [Ca+2] with the most

pronounced increase detected in the nuclear and perinuclear region of the cell. "

" Our results point to an important role of LT's in aortic valve stenosis

..LT-producing enzymes and LT receptors were upregulated in thickened valve

tissue.Further,5-LO,FLAP,LTC4S and LTA4H expression levels correlated

significantly with the severity of aortic valve stenosis.Also,LTC4 induced

nuclear calcium signaling,morphological changes,calcification,and mitochondrial

ROS (ie reactive oxygen species)production in valvular myofibroblasts "

In summary I believe this is probably a useful model for us for A.E.R.D..Also

the use of anti-inflammatory,anti-oxidants,and anti-leukotriene agents may be a

good starting point fo therapy.There is a lot more detail in this paper ,so best

to read it.Sincerely Wayne

[Guest guest]

Wayne,

I think any sort of inflammation that is prolonged long enough will eventualy

produce calcification. In that matter, the sinuses are not specific : reducing

the inflammation levels will also reduce the calcification, scarring and

remodeling processes.

>

> Aortic stenosis is a cause of sudden death.Read this today in Science daily

from the journal Circulation. " Inflammation behind heart valve

disease " Mar16,2011.A group of immune cells and leukotrienes found in calcified

heart valves.Statins capable of preventing arteriosclerosis but ineffective in

preventing calcification of the aortic valve.Anti-inflammatories could be a

future treatment.I need to know which group of immune cells is involved and if

there is any relation to this and calcifying sinuses?Sincerely Wayne

>