Re: Cant get rid of infection

[Guest guest]

Have you heard of Xylitol?

I found a study on xylitol an staph and the full text is available pubmed. Their

are xylitol nasal sprays available.

Web link xylitol nasal spray:

http://www.xlear.com/nasal-spray.aspx

From Wikipedia:

Xylitol (play /?za?l?t?l/; Greek: ?????, xyl[on], " wood " + suffix -itol, used to

denote sugar alcohols) is a sugar alcohol sweetener used as a naturally

occurring sugar substitute. It is found in the fibers of many fruits and

vegetables, and can be extracted from various berries, oats, and mushrooms, as

well as fibrous material such as corn husks and sugar cane bagasse, and birch.

Pubmed study:

The osmolyte xylitol reduces the salt concentration of airway surface liquid and

may enhance bacterial killing.

Zabner J, Seiler MP, Launspach JL, Karp PH, Kearney WR, Look DC, JJ, Welsh

MJ.

Source

Medical Institute, Departments of Internal Medicine, Pediatrics,

and Physiology and Biophysics, and Nuclear Magnetic Resonance Facility,

University of Iowa College of Medicine, Iowa City, IA 52242, USA.

joseph-zabner@...

Abstract

The thin layer of airway surface liquid (ASL) contains antimicrobial substances

that kill the small numbers of bacteria that are constantly being deposited in

the lungs. An increase in ASL salt concentration inhibits the activity of airway

antimicrobial factors and may partially explain the pathogenesis of cystic

fibrosis (CF). We tested the hypothesis that an osmolyte with a low

transepithelial permeability may lower the ASL salt concentration, thereby

enhancing innate immunity. We found that the five-carbon sugar xylitol has a low

transepithelial permeability, is poorly metabolized by several bacteria, and can

lower the ASL salt concentration in both CF and non-CF airway epithelia in

vitro. Furthermore, in a double-blind, randomized, crossover study, xylitol

sprayed for 4 days into each nostril of normal volunteers significantly

decreased the number of nasal coagulase-negative Staphylococcus compared with

saline control. Xylitol may be of value in decreasing ASL salt concentration and

enhancing the innate antimicrobial defense at the airway surface.

>

> I have had infections of the sinuses for so long and continue to be on

antibiotics. I am now on 2. I have a biofilm that has MRSA in it. I have a poor

sense of smell and have had many polyp surgeries, have had aspirin des. , on

Xolair injections , zyflo, and many asthma meds , Have others had Mrsa and how

did you manage with it?

>

[Guest guest]

Don't know about MRSA, but I did have pseudomonas which is also extremely

tenacious, and I went on IV therapy for two weeks with Ceftazidime. It seemed

to do the trick. Once they put the IV in my arm, a nurse came by to show me how

to give myself the meds twice a day - not too bad. Oral antibiotics frequently

don't work on chronic bacteria and biofilm. This last therapy seemed to work

(knock on wood) and I just had desens so hopefully I am in the clear. Ask about

IV therapy.

- In samters , " damianodavid " <damianodavid@...> wrote:

>

> Have you heard of Xylitol?

> I found a study on xylitol an staph and the full text is available pubmed.

Their are xylitol nasal sprays available.

>

> Web link xylitol nasal spray:

>

> http://www.xlear.com/nasal-spray.aspx

>

> From Wikipedia:

>

> Xylitol (play /?za?l?t?l/; Greek: ?????, xyl[on], " wood " + suffix -itol, used

to denote sugar alcohols) is a sugar alcohol sweetener used as a naturally

occurring sugar substitute. It is found in the fibers of many fruits and

vegetables, and can be extracted from various berries, oats, and mushrooms, as

well as fibrous material such as corn husks and sugar cane bagasse, and birch.

>

>

> Pubmed study:

>

> The osmolyte xylitol reduces the salt concentration of airway surface liquid

and may enhance bacterial killing.

> Zabner J, Seiler MP, Launspach JL, Karp PH, Kearney WR, Look DC, JJ,

Welsh MJ.

> Source

>

> Medical Institute, Departments of Internal Medicine, Pediatrics,

and Physiology and Biophysics, and Nuclear Magnetic Resonance Facility,

University of Iowa College of Medicine, Iowa City, IA 52242, USA.

joseph-zabner@...

> Abstract

>

> The thin layer of airway surface liquid (ASL) contains antimicrobial

substances that kill the small numbers of bacteria that are constantly being

deposited in the lungs. An increase in ASL salt concentration inhibits the

activity of airway antimicrobial factors and may partially explain the

pathogenesis of cystic fibrosis (CF). We tested the hypothesis that an osmolyte

with a low transepithelial permeability may lower the ASL salt concentration,

thereby enhancing innate immunity. We found that the five-carbon sugar xylitol

has a low transepithelial permeability, is poorly metabolized by several

bacteria, and can lower the ASL salt concentration in both CF and non-CF airway

epithelia in vitro. Furthermore, in a double-blind, randomized, crossover study,

xylitol sprayed for 4 days into each nostril of normal volunteers significantly

decreased the number of nasal coagulase-negative Staphylococcus compared with

saline control. Xylitol may be of value in decreasing ASL salt concentration and

enhancing the innate antimicrobial defense at the airway surface.

>

>

> >

> > I have had infections of the sinuses for so long and continue to be on

antibiotics. I am now on 2. I have a biofilm that has MRSA in it. I have a poor

sense of smell and have had many polyp surgeries, have had aspirin des. , on

Xolair injections , zyflo, and many asthma meds , Have others had Mrsa and how

did you manage with it?

> >

>

[Guest guest]

This is interesting. I’ve had an H.flu infection for months, have been on 4 different antibiotics and nothing has worked. They’re supposed to be doing a test to find an antibiotic it isn’t resistant to, but so far the lab has screwed up and done the wrong test, so I’m still waiting. Has anyone had luck with antibiotics directly in the nose?On Jul 31, 2011, at 6:20 PM, wrote:

Don't know about MRSA, but I did have pseudomonas which is also extremely tenacious, and I went on IV therapy for two weeks with Ceftazidime. It seemed to do the trick. Once they put the IV in my arm, a nurse came by to show me how to give myself the meds twice a day - not too bad. Oral antibiotics frequently don't work on chronic bacteria and biofilm. This last therapy seemed to work (knock on wood) and I just had desens so hopefully I am in the clear. Ask about IV therapy.

- In samters , "damianodavid" <damianodavid@...> wrote:

>

> Have you heard of Xylitol?

> I found a study on xylitol an staph and the full text is available pubmed. Their are xylitol nasal sprays available.

>

> Web link xylitol nasal spray:

>

> http://www.xlear.com/nasal-spray.aspx

>

> From Wikipedia:

>

> Xylitol (play /?za?l?t?l/; Greek: ?????, xyl[on], "wood" + suffix -itol, used to denote sugar alcohols) is a sugar alcohol sweetener used as a naturally occurring sugar substitute. It is found in the fibers of many fruits and vegetables, and can be extracted from various berries, oats, and mushrooms, as well as fibrous material such as corn husks and sugar cane bagasse, and birch.

>

>

> Pubmed study:

>

> The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing.

> Zabner J, Seiler MP, Launspach JL, Karp PH, Kearney WR, Look DC, JJ, Welsh MJ.

> Source

>

> Medical Institute, Departments of Internal Medicine, Pediatrics, and Physiology and Biophysics, and Nuclear Magnetic Resonance Facility, University of Iowa College of Medicine, Iowa City, IA 52242, USA. joseph-zabner@...

> Abstract

>

> The thin layer of airway surface liquid (ASL) contains antimicrobial substances that kill the small numbers of bacteria that are constantly being deposited in the lungs. An increase in ASL salt concentration inhibits the activity of airway antimicrobial factors and may partially explain the pathogenesis of cystic fibrosis (CF). We tested the hypothesis that an osmolyte with a low transepithelial permeability may lower the ASL salt concentration, thereby enhancing innate immunity. We found that the five-carbon sugar xylitol has a low transepithelial permeability, is poorly metabolized by several bacteria, and can lower the ASL salt concentration in both CF and non-CF airway epithelia in vitro. Furthermore, in a double-blind, randomized, crossover study, xylitol sprayed for 4 days into each nostril of normal volunteers significantly decreased the number of nasal coagulase-negative Staphylococcus compared with saline control. Xylitol may be of value in decreasing ASL salt

concentration and enhancing the innate antimicrobial defense at the airway surface.

>

>

> >

> > I have had infections of the sinuses for so long and continue to be on antibiotics. I am now on 2. I have a biofilm that has MRSA in it. I have a poor sense of smell and have had many polyp surgeries, have had aspirin des. , on Xolair injections , zyflo, and many asthma meds , Have others had Mrsa and how did you manage with it?

> >

>

[Guest guest]

Hi there!

I suffer from frequent MRSA sinus infections, several of which have involved

biofilms. Here is the current regimen that my doctors and I follow when I get

such an infection:

1) According to the infectious disease specialist that my ENT has me consult

with regarding MRSA, the only effective way to eliminate the biofilm is for my

ENT to suction it out. As I understand it, biofilms encapsulate the bacteria...

because of that, the bacteria is not exposed to the blood stream, which means

that antibiotics [whether given orally or via IV] have no impact on it.

Thankfully, due to the three sinus surgeries that I have had, my sinus passages

tend to be open enough that my ENT has had good success suctioning the sticky

biofilms out.

2) After my ENT cultures the bacteria, I am put on an antibiotic that has been

found to be effective against the MRSA. Given what I said in (1) about

antibiotics not being effective against biofilms, you may wonder why the doctors

still put me on an antibiotic. It is to kill any MRSA bacteria that is sitting

along my sinus passage linings but not actually inside the biofilm.

3) I use Q-tips to apply Mupirocin (a prescription ointment) to my sinus

passages. This helps to kill any bacteria in my sinus passage openings.

4) I use Hibiclens (an over-the-counter wash) when bathing. The infectious

disease specialist recommends that I do this to eradicate any MRSA that exists

on my skin outside of my sinus passages. He does not want me to use Hibiclens

all the time, as he worries that I would build up a resistance to it... instead,

he just has me use it while I am battling an infection.

5) The infectious disease specialist also recommends that I frequently clean

with antibacterial wipes everything I touch in my home and office.

6) After my last infection, I asked my ENT if there was anything else I could do

to try to prevent biofilms from taking root. He said that I might want to

include a little baby shampoo in a sinus rinse. He said that he washes the

sinus passages with baby shampoo at the end of surgery to help prevent biofilms

from forming.

For general Samter's maintenance, I take Allegra, Singulair, and Symbicort to

control my allergy and asthma symptoms. I am aspirin-desensitized, receive

allergy shots, and do daily sinus rinses with Pulmicort.

Hope this helps a little. Take care!

Debbie

>

> I have had infections of the sinuses for so long and continue to be on

antibiotics. I am now on 2. I have a biofilm that has MRSA in it. I have a poor

sense of smell and have had many polyp surgeries, have had aspirin des. , on

Xolair injections , zyflo, and many asthma meds , Have others had Mrsa and how

did you manage with it?

>

[Guest guest]

Wow, thanks. Lots of useful information. I may print it out for my doctor.On Jul 31, 2011, at 7:58 PM, dmeiers_al wrote:

Hi there!

I suffer from frequent MRSA sinus infections, several of which have involved biofilms. Here is the current regimen that my doctors and I follow when I get such an infection:

1) According to the infectious disease specialist that my ENT has me consult with regarding MRSA, the only effective way to eliminate the biofilm is for my ENT to suction it out. As I understand it, biofilms encapsulate the bacteria... because of that, the bacteria is not exposed to the blood stream, which means that antibiotics [whether given orally or via IV] have no impact on it. Thankfully, due to the three sinus surgeries that I have had, my sinus passages tend to be open enough that my ENT has had good success suctioning the sticky biofilms out.

2) After my ENT cultures the bacteria, I am put on an antibiotic that has been found to be effective against the MRSA. Given what I said in (1) about antibiotics not being effective against biofilms, you may wonder why the doctors still put me on an antibiotic. It is to kill any MRSA bacteria that is sitting along my sinus passage linings but not actually inside the biofilm.

3) I use Q-tips to apply Mupirocin (a prescription ointment) to my sinus passages. This helps to kill any bacteria in my sinus passage openings.

4) I use Hibiclens (an over-the-counter wash) when bathing. The infectious disease specialist recommends that I do this to eradicate any MRSA that exists on my skin outside of my sinus passages. He does not want me to use Hibiclens all the time, as he worries that I would build up a resistance to it... instead, he just has me use it while I am battling an infection.

5) The infectious disease specialist also recommends that I frequently clean with antibacterial wipes everything I touch in my home and office.

6) After my last infection, I asked my ENT if there was anything else I could do to try to prevent biofilms from taking root. He said that I might want to include a little baby shampoo in a sinus rinse. He said that he washes the sinus passages with baby shampoo at the end of surgery to help prevent biofilms from forming.

For general Samter's maintenance, I take Allegra, Singulair, and Symbicort to control my allergy and asthma symptoms. I am aspirin-desensitized, receive allergy shots, and do daily sinus rinses with Pulmicort.

Hope this helps a little. Take care!

Debbie

>

> I have had infections of the sinuses for so long and continue to be on antibiotics. I am now on 2. I have a biofilm that has MRSA in it. I have a poor sense of smell and have had many polyp surgeries, have had aspirin des. , on Xolair injections , zyflo, and many asthma meds , Have others had Mrsa and how did you manage with it?

>