Re: Sesame oil Nasal spray for nasal irritation and as a VEGF inhibitor

[Guest guest]

Thanks , this is very interesting.

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> I have been having problems with nasal irritation and nose bleeds as a result

of nasal steroid use and/or recent surgery. I have been using sesame oil nasal

spray I bought at a local compounding pharmacy and I do notice a difference. I

also found a study on sesame oil as a VEGF inhibitor. Has anyone else tried

this?

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> Rhinology. 2000 Dec;38(4):200-3.

> Fewer problems with dry nasal mucous membranes following local use of sesame

oil.

> Björk-sson T, Gunnarsson M, Holmström M, Nordqvist A, Petruson B.

> Source

>

> Department of Oncology, Sahlgrenska University Hospital, Göteborg, Sweden.

thomas.bjork-eriksson@...

> Abstract

>

> Many people experience problems with a dry nasal mucous membrane, often

without wondering why. Their noses itch and burn and dried mucus collects there.

These problems are exacerbated during the winter, in air-conditioned

environments and after nasal irradiation. Twenty patients experiencing problems

with dryness of the nose were selected from outpatient clinics, together with

twenty patients who had previously undergone nasal irradiation. During the first

five days no treatment was administered. For the following twenty days the

patients sprayed sesame oil into each nostril three times a day. For the last

five days no treatment was given. When both groups received treatment and

sprayed sesame oil (Nozoil) in their noses, the nasal problems decreased

significantly. The greatest effect is exerted on dryness. The side effects from

using this oil are few in number and mild.

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> Pure sesame oil vs isotonic sodium chloride solution as treatment for dry

nasal mucosa.

> sen J, Bratt BM, Michel-Barron O, Glennow C, Petruson B.

> Source

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> Department of Otorhinolaryngology, County Hospital, Skellefteå, Sweden.

> Abstract

> OBJECTIVE:

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> To evaluate whether there was any difference in efficacy when nasal mucosa

dryness was treated with pure sesame oil (Nozoil) compared with isotonic sodium

chloride solution (ISCS).

> DESIGN:In a randomized, crossover study, 79 subjects with nasal mucosa dryness

were enrolled. Half the subjects received pure sesame oil for 14 days followed

by ISCS for 14 days, and the other half received ISCS for 14 days followed by

pure sesame oil for 14 days. During the test period from March 13 to May 30,

2000, the outdoor absolute humidity was low. Nasal mucosa dryness, stuffiness,

and crusts were scored every evening with a visual analog scale.

> SETTING:

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> The County Hospital, Skellefteå, Sweden.

> RESULTS:

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> Nasal mucosa dryness improved significantly when pure sesame oil was used

compared with ISCS (P<.001). The improvement in nasal stuffiness was also better

with pure sesame oil (P<.001) as was improvement in nasal crusts (P<.001). Eight

of 10 subjects reported that their nasal symptoms had improved with pure sesame

oil compared with 3 of 10 for ISCS (P<.001). Adverse events were few and

temporary.

> CONCLUSION:

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> When nasal mucosa dryness due to a dry winter climate was treated, pure sesame

oil was shown statistically to be significantly more effective than ISCS.

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> Lee CC, Liu KJ, Wu YC, Lin SJ, Chang CC, Huang TS.

> National Institute of Cancer Research, National Health Research Institutes,

No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan, Republic of China.

>

> Abstract

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> Sesamin is a sesame component with antihypertensive and antioxidative

activities and has recently aroused much interest in studying its potential

anticancer application. Macrophage is one of the infiltrating inflammatory cells

in solid tumor and may promote tumor progression via enhancement of tumor

angiogenesis. In this study, we investigated whether sesamin inhibited

macrophage-enhanced proangiogenic activity of breast cancer cell lines MCF-7 and

MDA-MB-231. Using vascular endothelial cell capillary tube and network formation

assays, both breast cancer cell lines exhibited elevated proangiogenic

activities after coculture with macrophages or pretreatment with

macrophage-conditioned medium. This elevation of proangiogenic activity was

drastically suppressed by sesamin. Vascular endothelial growth factor (VEGF) and

matrix metalloproteinase-9 (MMP-9) induced by macrophages in both cell lines

were also inhibited by sesamin. Nuclear levels of HIF-1alpha and NF-kappaB,

important transcription factors for VEGF and MMP-9 expression, respectively,

were obviously reduced by sesamin. VEGF induction by macrophage in MCF-7 cells

was shown to be via ERK, JNK, phosphatidylinositol 3-kinase, and

NF-kappaB-mediated pathways. These signaling molecules and additional p38(MAPK)

were also involved in macrophage-induced MMP-9 expression. Despite such diverse

pathways were induced by macrophage, only Akt and p38(MAPK) activities were

potently inhibited by sesamin. Expression of interleukin (IL)-6, IL-8, and tumor

necrosis factor-alpha were substantially increased and involved in

macrophage-induced VEGF and MMP-9 mRNA expression in MCF-7 cells. Sesamin

effectively inhibited the expression of these cytokines to avoid the reinforced

induction of VEGF and MMP-9. In conclusion, sesamin potently inhibited

macrophage-enhanced proangiogenic activity of breast cancer cells via inhibition

of VEGF and MMP-9 induction.

> PMID: 20617373

>