Sesame oil Nasal spray for nasal irritation and as a VEGF inhibitor

[Guest guest]

I have been having problems with nasal irritation and nose bleeds as a result of

nasal steroid use and/or recent surgery. I have been using sesame oil nasal

spray I bought at a local compounding pharmacy and I do notice a difference. I

also found a study on sesame oil as a VEGF inhibitor. Has anyone else tried

this?

Rhinology. 2000 Dec;38(4):200-3.

Fewer problems with dry nasal mucous membranes following local use of sesame

oil.

Björk-sson T, Gunnarsson M, Holmström M, Nordqvist A, Petruson B.

Source

Department of Oncology, Sahlgrenska University Hospital, Göteborg, Sweden.

thomas.bjork-eriksson@...

Abstract

Many people experience problems with a dry nasal mucous membrane, often without

wondering why. Their noses itch and burn and dried mucus collects there. These

problems are exacerbated during the winter, in air-conditioned environments and

after nasal irradiation. Twenty patients experiencing problems with dryness of

the nose were selected from outpatient clinics, together with twenty patients

who had previously undergone nasal irradiation. During the first five days no

treatment was administered. For the following twenty days the patients sprayed

sesame oil into each nostril three times a day. For the last five days no

treatment was given. When both groups received treatment and sprayed sesame oil

(Nozoil) in their noses, the nasal problems decreased significantly. The

greatest effect is exerted on dryness. The side effects from using this oil are

few in number and mild.

Pure sesame oil vs isotonic sodium chloride solution as treatment for dry nasal

mucosa.

sen J, Bratt BM, Michel-Barron O, Glennow C, Petruson B.

Source

Department of Otorhinolaryngology, County Hospital, Skellefteå, Sweden.

Abstract

OBJECTIVE:

To evaluate whether there was any difference in efficacy when nasal mucosa

dryness was treated with pure sesame oil (Nozoil) compared with isotonic sodium

chloride solution (ISCS).

DESIGN:In a randomized, crossover study, 79 subjects with nasal mucosa dryness

were enrolled. Half the subjects received pure sesame oil for 14 days followed

by ISCS for 14 days, and the other half received ISCS for 14 days followed by

pure sesame oil for 14 days. During the test period from March 13 to May 30,

2000, the outdoor absolute humidity was low. Nasal mucosa dryness, stuffiness,

and crusts were scored every evening with a visual analog scale.

SETTING:

The County Hospital, Skellefteå, Sweden.

RESULTS:

Nasal mucosa dryness improved significantly when pure sesame oil was used

compared with ISCS (P<.001). The improvement in nasal stuffiness was also better

with pure sesame oil (P<.001) as was improvement in nasal crusts (P<.001). Eight

of 10 subjects reported that their nasal symptoms had improved with pure sesame

oil compared with 3 of 10 for ISCS (P<.001). Adverse events were few and

temporary.

CONCLUSION:

When nasal mucosa dryness due to a dry winter climate was treated, pure sesame

oil was shown statistically to be significantly more effective than ISCS.

Lee CC, Liu KJ, Wu YC, Lin SJ, Chang CC, Huang TS.

National Institute of Cancer Research, National Health Research Institutes, No.

35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan, Republic of China.

Abstract

Sesamin is a sesame component with antihypertensive and antioxidative activities

and has recently aroused much interest in studying its potential anticancer

application. Macrophage is one of the infiltrating inflammatory cells in solid

tumor and may promote tumor progression via enhancement of tumor angiogenesis.

In this study, we investigated whether sesamin inhibited macrophage-enhanced

proangiogenic activity of breast cancer cell lines MCF-7 and MDA-MB-231. Using

vascular endothelial cell capillary tube and network formation assays, both

breast cancer cell lines exhibited elevated proangiogenic activities after

coculture with macrophages or pretreatment with macrophage-conditioned medium.

This elevation of proangiogenic activity was drastically suppressed by sesamin.

Vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9)

induced by macrophages in both cell lines were also inhibited by sesamin.

Nuclear levels of HIF-1alpha and NF-kappaB, important transcription factors for

VEGF and MMP-9 expression, respectively, were obviously reduced by sesamin. VEGF

induction by macrophage in MCF-7 cells was shown to be via ERK, JNK,

phosphatidylinositol 3-kinase, and NF-kappaB-mediated pathways. These signaling

molecules and additional p38(MAPK) were also involved in macrophage-induced

MMP-9 expression. Despite such diverse pathways were induced by macrophage, only

Akt and p38(MAPK) activities were potently inhibited by sesamin. Expression of

interleukin (IL)-6, IL-8, and tumor necrosis factor-alpha were substantially

increased and involved in macrophage-induced VEGF and MMP-9 mRNA expression in

MCF-7 cells. Sesamin effectively inhibited the expression of these cytokines to

avoid the reinforced induction of VEGF and MMP-9. In conclusion, sesamin

potently inhibited macrophage-enhanced proangiogenic activity of breast cancer

cells via inhibition of VEGF and MMP-9 induction.

PMID: 20617373