AmphoB irrigation post-op not necessarily better than saline

[Guest guest]

(that is, if there is no reason to suspect fungal sinusitis)J Res Med Sci. 2011 Jan;16(1):74-8.Does amphotericin B nasal douching help prevent polyp recurrence following functional endoscopic sinus surgery?Hashemi SM, Mokhtarinejad F, Karim M, Okhovat SH.Associate Professor of Otolaryngology, Kashani Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.AbstractBACKGROUND: Recurrence of nasal polyposis following surgical intervention is very common. Antifungal therapy has been an appealing alternative to reduce its recurrence and severity. Early studies showed definite positive response, but recent studies have raised doubts about its efficacy in treatment of polyposis.METHODS: This prospective case-control clinical trial was conducted on 50 patients suffering from nasal polyposis in Isfahan University of medical sciences. All patients underwent functional endoscopic sinus surgery. CT scanning of paranasal sinuses was done preoperatively and 6 months postoperatively to stage the disease. Patients were assigned to two groups: amphotericine B group were instructed to irrigate the nasal cavity with a solution of amphotericine B, while the normal saline group used the physiologic normal saline for 6 months.RESULTS: 68% of patients in Normal saline and 84% of cases in amphotericine B group reported history of allergies. In amphotericine B group, stage of the disease improved in 84% of patients and remained unchanged in the rest. In normal saline group, imaging stage improved in 22 patients and remained unchanged in 3. The two cohorts were compared for reduction in imaging stage and no significant difference was found between them.CONCLUSIONS: This study showed no benefits for topical amphotericin B solution over normal saline. It might be better to retreat to the traditional normal saline nasal douching following functional endoscopic sinus surgery in the treatment of polyposis.

[Guest guest]

I did the Amp B nasal rinse mixed with something else..can't remember.  It was from the Mayo Clinic in Minn.  I was so sick and honestly never felt more like I was slowly dying then at that time.  I was on it for a month.  It was horrible stuff.

I called Mayo and they were not very interested in my issues with it.

Just my 2 cents.

Tami

True Ark CreationsTami's Berry Farmwww.truearkcreations.comEveryday holds a possibility of a miracle! 

On Mon, Apr 4, 2011 at 3:52 PM, asfy <asfyso@...> wrote:

 

(that is, if there is no reason to suspect fungal sinusitis)

J Res Med Sci. 2011 Jan;16(1):74-8.

Does amphotericin B nasal douching help prevent polyp recurrence following functional endoscopic sinus surgery?

Hashemi SM, Mokhtarinejad F, Karim M, Okhovat SH.

Associate Professor of Otolaryngology, Kashani Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

BACKGROUND: Recurrence of nasal polyposis following surgical intervention is very common. Antifungal therapy has been an appealing alternative to reduce its recurrence and severity. Early studies showed definite positive response, but recent studies have raised doubts about its efficacy in treatment of polyposis.

METHODS: This prospective case-control clinical trial was conducted on 50 patients suffering from nasal polyposis in Isfahan University of medical sciences. All patients underwent functional endoscopic sinus surgery. CT scanning of paranasal sinuses was done preoperatively and 6 months postoperatively to stage the disease. Patients were assigned to two groups: amphotericine B group were instructed to irrigate the nasal cavity with a solution of amphotericine B, while the normal saline group used the physiologic normal saline for 6 months.

RESULTS: 68% of patients in Normal saline and 84% of cases in amphotericine B group reported history of allergies. In amphotericine B group, stage of the disease improved in 84% of patients and remained unchanged in the rest. In normal saline group, imaging stage improved in 22 patients and remained unchanged in 3. The two cohorts were compared for reduction in imaging stage and no significant difference was found between them.

CONCLUSIONS: This study showed no benefits for topical amphotericin B solution over normal saline. It might be better to retreat to the traditional normal saline nasal douching following functional endoscopic sinus surgery in the treatment of polyposis.