The sinuses can seed the lungs with bacteria

[Guest guest]

ISME J. 2011 Jun 30. doi: 10.1038/ismej.2011.83. [Epub ahead of print]Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection.Hansen SK, Rau MH, Johansen HK, Ciofu O, Jelsbak L, Yang L, Folkesson A, Jarmer HO, Aanæs K, von Buchwald C, Høiby N, Molin S.SourceDepartment of Systems Biology, Technical University of Denmark, Lyngby, Denmark.AbstractThe opportunistic pathogen Pseudomonas aeruginosa is a frequent colonizer of the airways of patients suffering from cystic fibrosis (CF). Depending on early treatment regimens, the colonization will, with high probability, develop into chronic infections sooner or later, and it is important to establish under which conditions the switch to chronic infection takes place. In association with a recently established sinus surgery treatment program for CF patients at the Copenhagen CF Center, colonization of the paranasal sinuses with P. aeruginosa has been investigated, paralleled by sampling of sputum from the same patients. On the basis of genotyping and phenotypic characterization including transcription profiling, the diversity of the P. aeruginosa populations in the sinuses and the lower airways was investigated and compared. The observations made from several children show that the paranasal sinuses constitute an important niche for the colonizing bacteria in many patients. The paranasal sinuses often harbor distinct bacterial subpopulations, and in the early colonization phases there seems to be a migration from the sinuses to the lower airways, suggesting that independent adaptation and evolution take place in the sinuses. Importantly, before the onset of chronic lung infection, lineages with mutations conferring a large fitness benefit in CF airways such as mucA and lasR as well as small colony variants and antibiotic-resistant clones are part of the sinus populations. Thus, the paranasal sinuses potentially constitute a protected niche of adapted clones of P. aeruginosa, which can intermittently seed the lungs and pave the way for subsequent chronic lung infections.

[Guest guest]

I find this so very interesting, especially because my father suffered so terribly with lung disease and I have not had any asthma symptoms since age 14. I am now 52 and facing my 9th polyp surgery. I would be very interested to know how many of us with Samters Triad Disease suffer with only one of either Asthma or Polyps, but not both? Or, how many suffered with Polyps only for a time, but then began having asthma symptoms?JaneFrom: asfy <asfyso@...>Subject: The sinuses can seed the lungs with bacteriasamters Date: Sunday, July 3, 2011, 10:40 AM

ISME J. 2011 Jun 30. doi: 10.1038/ismej.2011.83. [Epub ahead of print]Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection.Hansen SK, Rau MH, Johansen HK, Ciofu O, Jelsbak L, Yang L, Folkesson A, Jarmer HO, Aanæs K, von Buchwald C, Høiby N, Molin S.SourceDepartment of Systems Biology, Technical University of Denmark, Lyngby, Denmark.AbstractThe opportunistic pathogen Pseudomonas aeruginosa is a frequent colonizer of the airways of patients suffering from cystic fibrosis (CF). Depending on early treatment regimens, the colonization will, with high probability, develop into chronic infections sooner or later, and it is important to establish under which conditions the switch to chronic infection takes place. In association with a recently established sinus surgery treatment program for CF patients at the Copenhagen CF Center, colonization of the paranasal sinuses with P. aeruginosa has been investigated, paralleled by sampling of sputum from the same patients. On the basis of genotyping and phenotypic characterization including transcription

profiling, the diversity of the P. aeruginosa populations in the sinuses and the lower airways was investigated and compared. The observations made from several children show that the paranasal sinuses constitute an important niche for the colonizing bacteria in many patients. The paranasal sinuses often harbor distinct bacterial subpopulations, and in the early colonization phases there seems to be a migration from the sinuses to the lower airways, suggesting that independent adaptation and evolution take place in the sinuses. Importantly, before the onset of chronic lung infection, lineages with mutations conferring a large fitness benefit in CF airways such as mucA and lasR as well as small colony variants and antibiotic-resistant clones are part of the sinus populations. Thus, the paranasal sinuses potentially constitute a protected niche of adapted clones of P. aeruginosa, which can intermittently seed the lungs and pave the way for

subsequent chronic lung infections.

[Guest guest]

A few months ago I posted an article about the effects of iodine in killing bacteria, fungi, microbes in the mucus membranes and the lungs.

Over the last couple of years there have been numerous studies identifying that iodine deficiency exists in the U.S., U.K., and Australian population. This condition is of greater significance for women.

Below is a link to a recent U.K. article

New Study Suggests UK Is Now Iodine-deficient Article Date: 11 Apr 2011 - 17:00 PDT

http://www.medicalnewstoday.com/releases/221960.php

-----Original Message-----From: samters [mailto:samters ]On Behalf Of asfySent: Sunday, July 03, 2011 11:40 AMsamters Subject: The sinuses can seed the lungs with bacteria

ISME J. 2011 Jun 30. doi: 10.1038/ismej.2011.83. [Epub ahead of print]

Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection.

Hansen SK, Rau MH, Johansen HK, Ciofu O, Jelsbak L, Yang L, Folkesson A, Jarmer HO, Aanæs K, von Buchwald C, Høiby N, Molin S.

Source

Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.

Abstract

The opportunistic pathogen Pseudomonas aeruginosa is a frequent colonizer of the airways of patients suffering from cystic fibrosis (CF). Depending on early treatment regimens, the colonization will, with high probability, develop into chronic infections sooner or later, and it is important to establish under which conditions the switch to chronic infection takes place. In association with a recently established sinus surgery treatment program for CF patients at the Copenhagen CF Center, colonization of the paranasal sinuses with P. aeruginosa has been investigated, paralleled by sampling of sputum from the same patients. On the basis of genotyping and phenotypic characterization including transcription profiling, the diversity of the P. aeruginosa populations in the sinuses and the lower airways was investigated and compared. The observations made from several children show that the paranasal sinuses constitute an important niche for the colonizing bacteria in many patients. The paranasal sinuses often harbor distinct bacterial subpopulations, and in the early colonization phases there seems to be a migration from the sinuses to the lower airways, suggesting that independent adaptation and evolution take place in the sinuses. Importantly, before the onset of chronic lung infection, lineages with mutations conferring a large fitness benefit in CF airways such as mucA and lasR as well as small colony variants and antibiotic-resistant clones are part of the sinus populations. Thus, the paranasal sinuses potentially constitute a protected niche of adapted clones of P. aeruginosa, which can intermittently seed the lungs and pave the way for subsequent chronic lung infections.