Re: A simple sinusitis classification test in the future ?

[Guest guest]

Looks the abstract didn't post ; here it is :

Laryngoscope. 2008 Oct 29. [Epub ahead of print]Click here to read Links

Proteomics Blood Testing to Distinguish Chronic Rhinosinusitis Subtypes.

Das S, Maeso PA, Becker AM, Prosser JD, Adam BL, Kountakis SE.

From the Department of Otolaryngology-Head and Neck Surgery (S.D.), The

Ohio State University, Columbus, Ohio, U.S.A.; the Department of

Otolaryngology-Head and Neck Surgery (P.A.M.), University of Texas

Medical Branch, Galveston, Texas, U.S.A.; and the Department of

Otolaryngology-Head and Neck Surgery (A.M.B., J.D.P., B-L.A., S.E.K.),

Medical College of Georgia, Augusta, Georgia, U.S.A.

OBJECTIVES:: To evaluate the potential of surface enhanced laser

desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS)

proteomic profiling of serum samples to distinguish chronic

rhinosinusitis subtypes.

STUDY DESIGN:: Translational study of serum samples from prospectively

enrolled patients undergoing sinus surgery. METHODS:: Patients

undergoing endoscopic sinus surgery for chronic rhinosinusitis with

nasal polyposis were prospectively enrolled in an ongoing, institutional

review board approved proteomics study.

SELDI-TOF-MS was performed on 42 serum samples in patients with chronic

rhinosinusitis with nasal polyposis

(15 patients diagnosed with allergic fungal rhinosinusitis, 10 patients

with Samter's triad, and 17 with chronic rhinosinusitis with nasal

polyposis). Classification tree analysis on protein spectra developed

from peaks detected in the 0 to 100 kD range was performed to identify

disease subtypes.

RESULTS:: SELDI-TOF-MS correctly identified patients with allergic

fungal rhinosinusitis from serum samples with 84% sensitivity and 90%

specificity, and correctly identified patients with Samter's triad with

88% sensitivity and 88% specificity in two subtype comparison groups.

SELDI-TOF-MS correctly identified patients with allergic fungal

rhinosinusitis with 76% sensitivity and 82% specificity, and correctly

identified patients with Samter's triad with 80% sensitivity and 90%

specificity in three subtype comparison groups.

CONCLUSION:: The study provides molecular evidence that allergic fungal

rhinosinusitis is a discrete subtype of chronic rhinosinusitis.

SELDI-TOF-MS is a promising technology that could lead to the

development of a rapid blood test, to identify severe chronic

rhinosinusitis subtypes. Further investigation into the utility of this

technology is warranted.

[Guest guest]

Amen. The part about being "subjected to reckless disbelief" and getting " appropriate treatment" totally fits my case. I suffered needlessly for years because I had a doctor who treated me a like overblown hypochondriac and poo pooed me when I kept telling her something else was wrong with me than the usual sinus troubles.

Evie

-- A simple sinusitis classification test in the future ?

The idea of trying to distinguish between the variants of chronic sinusitis (Samter's, fungal, etc) with a simple test is something many researchers have already written about, with little success. So, if this new blood testing concept (a type of mass spectrometry) is confirmed, it may well be a breakthrough. Hopefully, the day will come when Samter's patients won't be subjected to reckless disbelief by their docs anymore, and get appropriate treatment outright instead of having the sinuses go untreated or poorly treated for years.BTW, the test's name (SELDI-TOF-MS) is also something only researchers can invent ; maybe this is why they also try to use funny names such as SNOT so that they can be more easily remembered :-)-----------

Laryngoscope. 2008 Oct 29. [Epub ahead of print]

[Guest guest]

Hi Evie,

I found this recently which goes further on what you were talking

about. Very interesting article. Good news!

Hugo

>

> Amen. The part about being " subjected to reckless disbelief " and

getting "

> appropriate treatment " totally fits my case. I suffered needlessly

for years

> because I had a doctor who treated me a like overblown

hypochondriac and poo

> pooed me when I kept telling her something else was wrong with me

than the

> usual sinus troubles.

>

> Evie

>

> -- A simple sinusitis classification test in the

future ?

>

> The idea of trying to distinguish between the variants of chronic

sinusitis

> (Samter's, fungal, etc) with a simple test is something many

researchers

> have already written about, with little success. So, if this new

blood

> testing concept (a type of mass spectrometry) is confirmed, it may

well be a

> breakthrough. Hopefully, the day will come when Samter's patients

won't be

> subjected to reckless disbelief by their docs anymore, and get

appropriate

> treatment outright instead of having the sinuses go untreated or

poorly

> treated for years.

>

> BTW, the test's name (SELDI-TOF-MS) is also something only

researchers can

> invent ; maybe this is why they also try to use funny names such as

SNOT so

> that they can be more easily remembered :-)

>

> -----------

>

> Laryngoscope. 2008 Oct 29. [Epub ahead of print]

>

[Guest guest]

Sorry here is the article.

http://www.abcactionnews.com/content/taking_action_for_you/story/New-

blood-test-detects-chronic-sinusitis/RbPwmntZ90-6nEk_fZtwLQ.cspx

> >

> > Amen. The part about being " subjected to reckless disbelief " and

> getting "

> > appropriate treatment " totally fits my case. I suffered

needlessly

> for years

> > because I had a doctor who treated me a like overblown

> hypochondriac and poo

> > pooed me when I kept telling her something else was wrong with me

> than the

> > usual sinus troubles.

> >

> > Evie

> >

> > -- A simple sinusitis classification test in the

> future ?

> >

> > The idea of trying to distinguish between the variants of chronic

> sinusitis

> > (Samter's, fungal, etc) with a simple test is something many

> researchers

> > have already written about, with little success. So, if this new

> blood

> > testing concept (a type of mass spectrometry) is confirmed, it

may

> well be a

> > breakthrough. Hopefully, the day will come when Samter's patients

> won't be

> > subjected to reckless disbelief by their docs anymore, and get

> appropriate

> > treatment outright instead of having the sinuses go untreated or

> poorly

> > treated for years.

> >

> > BTW, the test's name (SELDI-TOF-MS) is also something only

> researchers can

> > invent ; maybe this is why they also try to use funny names such

as

> SNOT so

> > that they can be more easily remembered :-)

> >

> > -----------

> >

> > Laryngoscope. 2008 Oct 29. [Epub ahead of print]

> >

>

[Guest guest]

Unfortunately I keep getting an error message ‘page not found’

From: hugorebs

[mailto:villagefc@...]

Sent: Wednesday, 28 January 2009 4:06 AM

samters

Subject: Re: A simple sinusitis classification test in the

future ?

Sorry here is the article.

http://www.abcactionnews.com/content/taking_action_for_you/story/New-

blood-test-detects-chronic-sinusitis/RbPwmntZ90-6nEk_fZtwLQ.cspx

> >

> > Amen. The part about being " subjected to reckless

disbelief " and

> getting "

> > appropriate treatment " totally fits my case. I suffered

needlessly

> for years

> > because I had a doctor who treated me a like overblown

> hypochondriac and poo

> > pooed me when I kept telling her something else was wrong with me

> than the

> > usual sinus troubles.

> >

> > Evie

> >

> > -- A simple sinusitis classification test in the

> future ?

> >

> > The idea of trying to distinguish between the variants of chronic

> sinusitis

> > (Samter's, fungal, etc) with a simple test is something many

> researchers

> > have already written about, with little success. So, if this new

> blood

> > testing concept (a type of mass spectrometry) is confirmed, it

may

> well be a

> > breakthrough. Hopefully, the day will come when Samter's patients

> won't be

> > subjected to reckless disbelief by their docs anymore, and get

> appropriate

> > treatment outright instead of having the sinuses go untreated or

> poorly

> > treated for years.

> >

> > BTW, the test's name (SELDI-TOF-MS) is also something only

> researchers can

> > invent ; maybe this is why they also try to use funny names such

as

> SNOT so

> > that they can be more easily remembered :-)

> >

> > -----------

> >

> > Laryngoscope. 2008 Oct 29. [Epub ahead of print]

> >

>

[Guest guest]

For some reason as the link is on two lines it has cut off half of

the link. You need to copy and paste the whole address

Try again:

http://www.abcactionnews.com/content/taking_action_for_you/story/New-

blood-test-detects-chronic-sinusitis/RbPwmntZ90-6nEk_fZtwLQ.cspx

Hugo

> > >

> > > Amen. The part about being " subjected to reckless disbelief "

and

> > getting "

> > > appropriate treatment " totally fits my case. I suffered

> needlessly

> > for years

> > > because I had a doctor who treated me a like overblown

> > hypochondriac and poo

> > > pooed me when I kept telling her something else was wrong with

me

> > than the

> > > usual sinus troubles.

> > >

> > > Evie

> > >

> > > -- A simple sinusitis classification test in

the

> > future ?

> > >

> > > The idea of trying to distinguish between the variants of

chronic

> > sinusitis

> > > (Samter's, fungal, etc) with a simple test is something many

> > researchers

> > > have already written about, with little success. So, if this

new

> > blood

> > > testing concept (a type of mass spectrometry) is confirmed, it

> may

> > well be a

> > > breakthrough. Hopefully, the day will come when Samter's

patients

> > won't be

> > > subjected to reckless disbelief by their docs anymore, and get

> > appropriate

> > > treatment outright instead of having the sinuses go untreated

or

> > poorly

> > > treated for years.

> > >

> > > BTW, the test's name (SELDI-TOF-MS) is also something only

> > researchers can

> > > invent ; maybe this is why they also try to use funny names

such

> as

> > SNOT so

> > > that they can be more easily remembered :-)

> > >

> > > -----------

> > >

> > > Laryngoscope. 2008 Oct 29. [Epub ahead of print]

> > >

> >

>

[Guest guest]

Thank you for the link, I am reading it now. That is pretty cool that they can do that test.

Evie

-- A simple sinusitis classification test in the > > future ?> > > > > > The idea of trying to distinguish between the variants of chronic > > sinusitis> > > (Samter's, fungal, etc) with a simple test is something many > > researchers> > > have already written about, with little success. So, if this new > > blood> > > testing concept (a type of mass spectrometry) is confirmed, it > may > > well be a> > > breakthrough. Hopefully, the day will come when Samter's patients > > won't be> > > subjected to reckless disbelief by their docs anymore, and get > > appropriate> > > treatment outright instead of having the sinuses go untreated or > > poorly> > > treated for years.> > > > > > BTW, the test's name (SELDI-TOF-MS) is also something only > > researchers can> > > invent ; maybe this is why they also try to use funny names such > as > > SNOT so> > > that they can be more easily remembered :-)> > > > > > -----------> > > > > > Laryngoscope. 2008 Oct 29. [Epub ahead of print]> > >> >>

[Guest guest]

Thanks Huge, it worked this time. Very interesting and the blocked

sinus?, we all know how that feels.  Have to admit she’s a very talented

artist.

From: hugorebs

[mailto:villagefc@...]

Sent: Wednesday, 28 January 2009 10:02 AM

samters

Subject: Re: A simple sinusitis classification test in the

future ?

For some reason as the link is on two lines it

has cut off half of

the link. You need to copy and paste the whole address

Try again:

http://www.abcactionnews.com/content/taking_action_for_you/story/New-

blood-test-detects-chronic-sinusitis/RbPwmntZ90-6nEk_fZtwLQ.cspx

Hugo

> > >

> > > Amen. The part about being " subjected to reckless disbelief "

and

> > getting "

> > > appropriate treatment " totally fits my case. I suffered

> needlessly

> > for years

> > > because I had a doctor who treated me a like overblown

> > hypochondriac and poo

> > > pooed me when I kept telling her something else was wrong with

me

> > than the

> > > usual sinus troubles.

> > >

> > > Evie

> > >

> > > -- A simple sinusitis classification test in

the

> > future ?

> > >

> > > The idea of trying to distinguish between the variants of

chronic

> > sinusitis

> > > (Samter's, fungal, etc) with a simple test is something many

> > researchers

> > > have already written about, with little success. So, if this

new

> > blood

> > > testing concept (a type of mass spectrometry) is confirmed, it

> may

> > well be a

> > > breakthrough. Hopefully, the day will come when Samter's

patients

> > won't be

> > > subjected to reckless disbelief by their docs anymore, and get

> > appropriate

> > > treatment outright instead of having the sinuses go untreated

or

> > poorly

> > > treated for years.

> > >

> > > BTW, the test's name (SELDI-TOF-MS) is also something only

> > researchers can

> > > invent ; maybe this is why they also try to use funny names

such

> as

> > SNOT so

> > > that they can be more easily remembered :-)

> > >

> > > -----------

> > >

> > > Laryngoscope. 2008 Oct 29. [Epub ahead of print]

> > >

> >

>