Re: Diesel fumes make polyps grow and aggravate AERDs

[Guest guest]

I appreicate all the articles you find and post here and your efforts

to find things in the scientific literature to help us and to figure

out what's behind Samter's -- but sometimes I feel like you really

editorialize with your " headlines. "

I don't see anywhere in this article where it says anything about nasal

polyps or making aspirin-exacerbated respiratory disease worse. Am I

missing something? The article does talk about IgE. Samter's is not

IgE mediated, as far as I understand it. Some people such as myself

have high IgE levels but it's not necessarily related to the Samter's.

And some people may have high IgE level with Churg-Strauss and Samter's

together in one person.

I'm quite sure exhaust fumes are bad for everybody, diesel or not,

Samters or not.

Lori

[Guest guest]

This is why I added a few lines of explanatory comments before the articles.

Sorry if they

were not clear enough - I sometimes post as fast as I can when I am short on

time and

afraid I will forget to post the article in question the next time I connect to

the newsgroup

- so please don't hesitate to say so when this is the case.

Here is the full demonstration of the post's title :

---> Diesel fumes make polyps grow

This is a deduction from the article titled :

" Diesel exhaust particles upregulate eotaxin gene expression in human bronchial

epithelial cells via nuclear factor-kappa B-dependent pathway "

As I pointed out in the comments, eotaxin is a signaling molecule which summons

eosinophils to an infection/inflammation site :

http://en.wikipedia.org/wiki/CCL11

Eosinophils are white blood cells that are part of the immune response. They are

very

useful in a number of situations (fighting parasites, for instance), but it

happens that they

are overproduced in most nasal polyps :

" Eosinophil cells are the most commonly identified inflammatory cell (of nasal

polyps),

occurring in 80-90% of polyps. "

from :

http://www.emedicine.com/ped/topic1550.htm

This is true for nasal polyps in general, and this is also true in Samter's

polyps, which are

eosinophil polyps (this is explained in :

J Allergy Clin Immunol. 2006 Oct;118(4):773-86; quiz 787-8. Epub 2006 Sep 1.

Links

Clinical and pathologic perspectives on aspirin sensitivity and asthma.

son DD, Szczeklik A.

Division of Allergy, Asthma and Immunology and the Department of Medicine,

Scripps

Clinic and the Scripps Research Institute, La Jolla, USA. dstevemd@...

So, when diesel particles reach an epithelium, they increase local production of

eotaxin,

which in turn summons more eosinophils, which, in nasal epithelium, supports

polyps'

inflammation and growth. In fact, anything that stimulates eosinophils is bad

for polyps.

What is notable with diesel is that its action on eosinophils is dose-dependant,

which

means the more you breath diesel fumes, the worse an eosinophil inflammation

gets.

Of course, you are right to point out that breathing any fumes is bad for the

nose and

lungs !

----> Diesel aggravates AERDs

This follows from the previous demonstration : AERD are (among others)

eosinophil-

mediated, so whatever increases eosinophil infiltration locally automatically

aggravates

AERDs.

But this also follows from another article I quoted, titled :

J Immunol. 2005 Feb 15;174(4):2412-9. Links

Cellular basis of the role of diesel exhaust particles in inducing Th2-dominant

response.Ohtani T, Nakagawa S, Kurosawa M, Mizuashi M, Ozawa M, Aiba S.

Department of Dermatology, Tohoku University Graduate School of Medicine,

Sendai,

Japan.

The article's title says that diesel induces a Th2-dominant response. AERDs

happen to be a

Th2-dominant disease. This can be deduced from the 2006 article by son and

Szczeklik in the Journal of Allergy and Clinical Immunology, where a graphic

(figure 1 in

the article) clearly shows that Th2 cells are among the 3 major cell mediators

of AERDs,

along with eosinophils and mast-cells.

By the way, I wish I could post the graphic, but I am afraid this would be a

copyright

infringement. This is a really thorough article, with some the best drawings on

AERDs I

have seen, and would be well worth including in the group's library. Perhaps you

could

contact the Journal of Allergy and Clinical Immunology on behalf of the group,

and ask for

a permission to freely reproduce the article ?

>

> I appreicate all the articles you find and post here and your efforts

> to find things in the scientific literature to help us and to figure

> out what's behind Samter's -- but sometimes I feel like you really

> editorialize with your " headlines. "

>

> I don't see anywhere in this article where it says anything about nasal

> polyps or making aspirin-exacerbated respiratory disease worse. Am I

> missing something? The article does talk about IgE. Samter's is not

> IgE mediated, as far as I understand it. Some people such as myself

> have high IgE levels but it's not necessarily related to the Samter's.

> And some people may have high IgE level with Churg-Strauss and Samter's

> together in one person.

>

> I'm quite sure exhaust fumes are bad for everybody, diesel or not,

> Samters or not.

>

> Lori

>