Guest guest Posted March 5, 2011 Report Share Posted March 5, 2011 > > Hi, I seem to have Samaters and have been rather unwell for mths now. Now stabilising on flixonse nasal drops, singulair, anti histamines and inhalers for asthma. Have just started the salicylate free diet which is a bit of a nigghtmare. Would be grateful to hear from anyone who has tried this and if it worked for them? Any alternatives.Had CT this week so will see GP again then. Any advice would be welcome !! > hi to keep it short i have had samsters for twenty years now , the diet dose work , and will help , its like a glass that is full , you need to keep the salicyates lower than that , in your body , keep it at quarter full if you can , then you have room to move , like eat something you normally coudnt , it takes time to get it right but once you do life can be nearly normal again .cheers craig . Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 6, 2011 Report Share Posted March 6, 2011 I have an observation and question: Observation: Neither my experience nor the literature I've read supports the belief that a salicylate free diet helps Samters. Aspirin, which is an acetylated salicylate, is a COX-1 inhibitor, apparently because of its acetyl group, eg this statement in a journal article: "...aspirin inhibits cyclooxygenase-1 (COX-1) activity by acetylating..." This COX1 inhibition is supposed to be why aspirin aggravates Samters. But other salicylates are apparently different, eg this statement in a journal article: " Salicylate does not affect COX-1 or COX-2 activity." My experience supports this: Aspirin has nearly killed me but sodium salicylate and bismuth subsalicylate (Pepto Bismol) have no noticeable effect. Question: Does anybody know if I have this right. If so, is a salicylate-free diet a rational way to treat Samters? Thanks. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 7, 2011 Report Share Posted March 7, 2011 I don't know the science, whether there is s a difference between aspirin and other salicylates. It's an interesting question. My own personal experience is that before desensitization I did react to salicylates in food quite strongly. I also found a salicylate free diet extremely depressing and almost impossible to follow. And if you live where there are willow trees or aspens, there are salicylates from the bark in the air. On Mar 6, 2011, at 2:37 PM, Larry wrote: I have an observation and question: Observation: Neither my experience nor the literature I've read supports the belief that a salicylate free diet helps Samters. Aspirin, which is an acetylated salicylate, is a COX-1 inhibitor, apparently because of its acetyl group, eg this statement in a journal article: "...aspirin inhibits cyclooxygenase-1 (COX-1) activity by acetylating..." This COX1 inhibition is supposed to be why aspirin aggravates Samters. But other salicylates are apparently different, eg this statement in a journal article: " Salicylate does not affect COX-1 or COX-2 activity." My experience supports this: Aspirin has nearly killed me but sodium salicylate and bismuth subsalicylate (Pepto Bismol) have no noticeable effect. Question: Does anybody know if I have this right. If so, is a salicylate-free diet a rational way to treat Samters? Thanks. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 7, 2011 Report Share Posted March 7, 2011 my boyfriends doctor said that there was no reason to avoid foods with salicylates.. however, he was desensitized. > > > I have an observation and question: > > Observation: Neither my experience nor the literature I've read supports the belief that a salicylate free diet helps Samters. Aspirin, which is an acetylated salicylate, is a COX-1 inhibitor, apparently because of its acetyl group, eg this statement in a journal article: " ...aspirin inhibits cyclooxygenase-1 (COX-1) activity by acetylating... " This COX1 inhibition is supposed to be why aspirin aggravates Samters. But other salicylates are apparently different, eg this statement in a journal article: " Salicylate does not affect COX-1 or COX-2 activity. " My experience supports this: Aspirin has nearly killed me but sodium salicylate and bismuth subsalicylate (Pepto Bismol) have no noticeable effect. > > Question: Does anybody know if I have this right. If so, is a salicylate-free diet a rational way to treat Samters? Thanks. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 7, 2011 Report Share Posted March 7, 2011 I have never been Aspirin desensitized and I do not watch my diet at all. One aspirin almost killed me and put me in the hospital for awhile but I have never had any reaction to anything I have eaten or drunk. I do avoid aspirin and any medicines that have aspirin in their makeup. I also have no allergies, food or otherwise, which can trigger adverse reactions in some people. Remember that everyone is different. > > Hi, I seem to have Samaters and have been rather unwell for mths now. Now stabilising on flixonse nasal drops, singulair, anti histamines and inhalers for asthma. Have just started the salicylate free diet which is a bit of a nigghtmare. Would be grateful to hear from anyone who has tried this and if it worked for them? Any alternatives.Had CT this week so will see GP again then. Any advice would be welcome !! > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 7, 2011 Report Share Posted March 7, 2011 Larry,That is an excellent and tough question.First, Aspirin does work by COX-1 acetylation. Salicylates do have real effects but are weak inhibitors of COX and therefore may also have other means of action that have not been fully elucidated yet. Naturally salicylated compounds, such as willow bark, actually contain a number of other active principles that may also be responsible for their effects, perhaps even more than salicylates. Second, AERDs are linked to an overproduction of leukotrienes relatively to prostaglandin production, so the rational "avoidance" strategy actually is to avoid anything that will upset this ratio. Third, salicylate-avoidance diets may work either because of salicylate avoidance, or because they also imply avoiding foods that have effects through other active principles - or a combination of both. They may also work poorly, depending on the individual. Overall, published experiments and educated guesses help make useful hypothesis. This being said, in practice, it's up to everyone to see what causes the typical reactions and to what extent, also remembering the fact that AERD may coexist (or not) with a number of other triggered conditions (notably allergies) that may confuse analysis.>> > I have an observation and question: > > Observation: Neither my experience nor the literature I've read supports the belief that a salicylate free diet helps Samters. Aspirin, which is an acetylated salicylate, is a COX-1 inhibitor, apparently because of its acetyl group, eg this statement in a journal article: "...aspirin inhibits cyclooxygenase-1 (COX-1) activity by acetylating..." This COX1 inhibition is supposed to be why aspirin aggravates Samters. But other salicylates are apparently different, eg this statement in a journal article: " Salicylate does not affect COX-1 or COX-2 activity." My experience supports this: Aspirin has nearly killed me but sodium salicylate and bismuth subsalicylate (Pepto Bismol) have no noticeable effect.> > Question: Does anybody know if I have this right. If so, is a salicylate-free diet a rational way to treat Samters? Thanks.> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 8, 2011 Report Share Posted March 8, 2011 The science is interesting, but we are complex biological animals with unique sensitivities and responses. Science and statistics are useful to steer us to helpful solutions, but the only meaningful result is individual reaction to treatment. The bottom line is that it either helps you or it does not. If not, move on. If it does help and you can tolerate a limited diet, that's great. > > > I have an observation and question: > > Observation: Neither my experience nor the literature I've read supports the belief that a salicylate free diet helps Samters. Aspirin, which is an acetylated salicylate, is a COX-1 inhibitor, apparently because of its acetyl group, eg this statement in a journal article: " ...aspirin inhibits cyclooxygenase-1 (COX-1) activity by acetylating... " This COX1 inhibition is supposed to be why aspirin aggravates Samters. But other salicylates are apparently different, eg this statement in a journal article: " Salicylate does not affect COX-1 or COX-2 activity. " My experience supports this: Aspirin has nearly killed me but sodium salicylate and bismuth subsalicylate (Pepto Bismol) have no noticeable effect. > > Question: Does anybody know if I have this right. If so, is a salicylate-free diet a rational way to treat Samters? Thanks. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 10, 2011 Report Share Posted March 10, 2011 My doctor explained it to me in quite the same way that is stated below, that the chemical make up is completely different and there is no reason to avoid foods with salicylates in them..... From: lynn b <itsrosie30@...>samters Sent: Mon, March 7, 2011 6:15:01 PMSubject: Re: salicylate free diet my boyfriends doctor said that there was no reason to avoid foods with salicylates.. however, he was desensitized.>> > I have an observation and question: > > Observation: Neither my experience nor the literature I've read supports the belief that a salicylate free diet helps Samters. Aspirin, which is an acetylated salicylate, is a COX-1 inhibitor, apparently because of its acetyl group, eg this statement in a journal article: "...aspirin inhibits cyclooxygenase-1 (COX-1) activity by acetylating..." This COX1 inhibition is supposed to be why aspirin aggravates Samters. But other salicylates are apparently different, eg this statement in a journal article: " Salicylate does not affect COX-1 or COX-2 activity." My experience supports this: Aspirin has nearly killed me but sodium salicylate and bismuth subsalicylate (Pepto Bismol) have no noticeable effect.> > Question: Does anybody know if I have this right. If so, is a salicylate-free diet a rational way to treat Samters? Thanks.> Quote Link to comment Share on other sites More sharing options...
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