Re: Re: Omega 3's.

September 18, 2008

I remember reading somewhere ( I will see if I can find it ) that we should limit Omega 6s and try to increase Omega 3's. I remember them mentioning that farm raised Talapia is very high in Omega 6's and should be avoided. Wild fish is high in Omega 3's.

Omega 3's.> > > There is still some concern about those with aspirin sensitivity andomega 3's. > > When plugging in flaxseed oil and aspirin sensitivity I got this:> "Asthmatics who are sensitive to aspirin should not take omega-3oils because they may intensify their sensitivity. "> > I know that most people with asthma react positively to omega 3's. But I do think we have to monitor our own reactions individually.>

September 19, 2008

In the book: Food Allergies and Food Intolerance By Brostoff, Gamlin

There is information about how our bodies (Samter's) may not treat omegs 3's the same way as others. It's on page 77 and you can google it.

And there are more studies being done. On some fish oil/omega 3 sites you will see warnings that you should be careful if you are allergic to aspirin.

These are theories, and while they have not been proven, at very least we should be cautious of this. Maybe it's certain omega e's, for instance: flax seed oil vs. fish oil. But we don't know. We don't know why our bodies produce too many leukrotrines.

But this says our bodies have a different metabolism of prostaglandins ... and omega 3's may effect that as well.

There are earlier studies that show there was no difference or a decline in people with aspirin sensitivity and fish oil.

The bottom line is we don't know. And I hope this at least gives us something to think about ... especially in those that aren't finding relief or that are having a decline in their health.

Michele

From: asfyso <asfyso@...>Subject: Re: Omega 3's.samters Date: Thursday, September 18, 2008, 5:47 PM

Do you have the reference of the text mentioning potential isolatedOmega3-sensitivity in aspirin-sensitive asthma patients ?There may have been a case mentioned in literature, perhaps, but thisis definitely not the general norm.As you mentioned, most, if not all studies, rather point out theBENEFICIAL effect of Omega3s on asthma, even on aspirin-sensitiveasthma, consistent with theory.See below for a few examples, and especially the first article aboutthree salicylate-sensitiv e patients feeling better with 10g fish oilsdaily.(Unless you really want to experiment, I would not recommend a dose ashigh as 10g daily, except very short term. Eskimaus might eat thatdaily, but their metabolism has been adapted over time by naturalselection to tolerate such levels better than the average person. Andeven then there may be side effects not mentioned. Also note that thearticle speaks of salicylate

sensitivity, not Samter's, which is notexactly the same thing - but still close enough of course.)Regarding sensitivity, I would interpret the quotation as possiblymeaning : if you evict Omega6s, and replace them only by Omega3s, youmight experience increased Omega6s sensitivity, which would be logical. Anyhow, it is not recommended to totally evict Omega6s. We need themjust as we need Omega3s, so a more moderate advice would be toincrease O3s, especially through fish oil supplementation, decreaseO6s, decrease direct arachidonic acid (eggs, fat meat, farmed fish).Avoid all trans fats (hydrogenated oils). Never try to totally evict ALL fats ; just eat BETTER fats.And if you really feel adventurous, you can always try some high-levelfish oil supplementation, but not too high and only on a very shortterm basis (not more than a few weeks at most) to see if you wouldrespond to that. For

some info on the inflammatory content of foods, arecommended reading is Dr. Chilton's book "Inflammation Nation".Br J Dermatol. 2008 Sep 15. [Epub ahead of print]------------ --Control of salicylate intolerance with fish oils.------------ --Healy E, Newell L, Howarth P, Friedmann PS.Dermatopharmacology Unit, Southampton University Hospitals Trust,Southampton SO16 6YD, U.K.We report three patients with disabling salicylate-inducedintolerance who experienced abrogation of symptoms following dietarysupplementation with omega-3 polyunsaturated fatty acids (PUFAs). Allthree patients experienced severe urticaria, asthma requiring systemicsteroid therapy and anaphylactic reactions. After dietarysupplementation with 10 g daily of fish oils rich in omega-3 PUFAs for6-8 weeks all three experienced complete or virtually completeresolution of symptoms allowing discontinuation of

systemiccorticosteroid therapy. Symptoms relapsed after dose reduction. Fishoil appears a safe and effective treatment for this difficult andoften serious condition.Am J Clin Nutr. 2008 Jul;88(1):167- 75.Click here to read Links------------ - Fish oil intake compared with olive oil intake in late pregnancy andasthma in the offspring: 16 y of registry-based follow-up from arandomized controlled trial.------------ -Olsen SF, Østerdal ML, Salvig JD, Mortensen LM, Rytter D, SecherNJ, Henriksen TB.Maternal Nutrition Group, Department of Epidemiology Research,Statens Serum Institut, Copenhagen, Denmark. sfo@...BACKGROUND: Evidence suggests that asthma is rooted in theintrauterine environment and that intake of marine n-3 polyunsaturatedfatty acids (n-3 PUFAs) in pregnancy may have immunomodulatory effectson the child.

OBJECTIVE: Our aim was to examine whether increasingmaternal intake of n-3 PUFAs in pregnancy may affect offspring risk ofasthma. DESIGN: In 1990, a population-based sample of 533 women withnormal pregnancies were randomly assigned 2:1:1 to receive four 1-ggelatin capsules/d with fish oil providing 2.7 g n-3 PUFAs (n = 266);four 1-g, similar-looking capsules/d with olive oil (n = 136); or nooil capsules (n = 131). Women were recruited and randomly assignedaround gestation week 30 and asked to take capsules until delivery.Among 531 live-born children, 528 were identified in registries and523 were still alive by August 2006. Diagnoses from the InternationalCoding of Diseases version 10 were extracted from a mandatory registrythat recorded diagnoses reported from hospital contacts. RESULTS:During the 16 y that passed since childbirth, 19 children from thefish oil and olive oil groups had received an

asthma-relateddiagnosis; 10 had received the diagnosis allergic asthma. The hazardrate of asthma was reduced by 63% (95% CI: 8%, 85%; P = 0.03), whereasthe hazard rate of allergic asthma was reduced by 87% (95% CI: 40%,97%; P = 0.01) in the fish oil compared with the olive oil group.CONCLUSION: Under the assumption that intake of olive oil in the doseprovided here was inert, our results support that increasing n-3 PUFAsin late pregnancy may carry an important prophylactic potential inrelation to offspring asthma.Exerc Sport Sci Rev. 2008 Jul;36(3):135- 44.Click here to read Links----------- A nutritional approach to managing exercise-induced asthma.------------ Mickleborough TD.Department of Kinesiology, Indiana University, Bloomington, IN47401, United States. tmicklebindiana (DOT) eduExercise-induced asthma (EIA) is

traditionally treated with theuse of pharmacotherapy. However, there is now convincing evidence thata variety of dietary factors such as elevated omega-3 polyunsaturatedfatty acids and antioxidant intake, and a sodium-restricted diet canreduce this condition. New therapies that are safe, effective, andlikely to be used by individuals with EIA are needed.Curr Med Res Opin. 2008 Feb;24(2):559- 67.Click here to read Links---------- The impact of a medical food containing gammalinolenic andeicosapentaenoic acids on asthma management and the quality of life ofadult asthma patients.-----------Surette ME, Stull D, Lindemann J.Department of Chemistry and Biochemistry, University of Moncton,Moncton, NB, Canada. marc.surette@ umoncton. caBACKGROUND: Leukotriene synthesis inhibitors and receptorantagonists are efficacious

for the treatment of asthma. Dietscontaining the fatty acids gammalinolenic acid (GLA) andeicosapentaenoic acid (EPA) decrease leukotriene synthesis; however,their impact on asthma management and quality of life (QOL) has notbeen evaluated in asthmatic subjects. OBJECTIVE: To evaluate asthmamanagement and the QOL of asthmatic adult subjects consuming a medicalfood emulsion containing GLA and EPA. RESEARCH DESIGN AND METHODS:Trial 1 was a randomized, prospective, double-blind,placebo-controlled, parallel group trial in atopic subjects withmild-to-moderate asthma (n = 35 evaluable) consuming a low dose (0.75g GLA + 0.5 g EPA), high dose (1.13 g GLA + 0.75 g EPA) or placeboemulsion daily. Subjects were questioned about their asthma managementusing a non-validated questionnaire after 2 and 4 weeks. Bloodleukotrienes were measured at baseline and after 4 weeks. Trial 2 wasan open-label study (n = 65

evaluable) where subjects consumed thelow-dose medical food emulsion, EFF1009, daily. QOL and asthmamanagement were measured using the validated Mini Asthma Quality ofLife (MiniAQLQ) and the Asthma Control (ACQ) questionnaires,respectively, administered at baseline and after 4 weeks. RESULTS: InTrial 1, leukotriene biosynthesis decreased (p < 0.05). Self-reportedasthma status and bronchodilator use improved in subjects consuminglow- and high-dose emulsion between week 2 and week 4 (p < 0.01), butnot compared to placebo (p > 0.1). In Trial 2, mean +/- standard errortotal MiniAQLQ and ACQ scores improved by 1.5 +/- 0.2 and 1.0 +/- 0.1,respectively (p < 0.001). Subdomain scores from MiniAQLQ improved andrescue bronchodilator use decreased (p < 0.001). CONCLUSION: Theinclusion of the medical food EFF1009 in asthma management regimenscan improve patient quality of life and decrease reliance

on rescuemedication.Rev Clin Esp. 2007 Jan;207(1):24- 5.Click here to read Links------------ [influence of omega 3 fatty acid dietary intake on asthma] [Articlein Spanish]------------de DA, León R, Izaola O.Instituto de Endocrinologí a y Nutrición, Facultad de Medicina,Unidad de Apoyo a la Investigación, Hospital Universitario RíoHortega, Valladolid, España. dadluis (DOT) esResults of clinical studies are contradictories, with differentresults in adults and children. Some studies detected a beneficialeffect of Omega 3 (w3) fatty acid dietary intake in the risk of asthmaand other studies have demonstrated a beneficial effect on clinicalsymptoms. In our area, a low intake of w3 fatty acids is rare.However, we need to recommend a right intake of w3 and w6 fattypolyunsaturated fatty acids to reach a good

ratio w-6/w-3. Perhaps,the influence of polyunsaturated fatty acid intake could be due to theratio w-6/w-3 and no to the total amount of w3 intake. A generalrecommendation is a dietary intake of fish three times each week, oneof them fat fish.Int J Tuberc Lung Dis. 2007 Jan;11(1):103- 9.Click here to read Links---------- Fat and fish intake and asthma in Japanese women: baseline data fromthe Osaka Maternal and Child Health Study.----------- Miyamoto S, Miyake Y, Sasaki S, Tanaka K, Ohya Y, Matsunaga I, YoshidaT, Oda H, Ishiko O, Hirota Y; Osaka Maternal and Child Health Study Group.Department of Public Health, Osaka City University Graduate Schoolof Medicine, Osaka, Japan.OBJECTIVE: It remains controversial whether the intake of n-3polyunsaturated fatty acids and fish is preventive against asthma.This cross-sectional study investigated the relationship between fatand fish intake and

the prevalence of asthma using baseline data froma prospective study. DESIGN: The subjects were 1002 pregnant Japanesefemales. A diet history questionnaire was used to assess dietaryhabits. Current asthma and asthma after age 18 were defined as presentif subjects had been treated with medications at some time in theprevious 12 months and after reaching the age of 18, respectively.RESULTS: Fish consumption was independently associated with adecreased prevalence of asthma after age 18 and current asthma. Asignificant inverse relationship was observed between the ratio of n-3to n-6 polyunsaturated fatty acid intake and the prevalence of currentasthma, but not asthma after age 18. Intake of total fat, saturated,monounsaturated, n-3 polyunsaturated and n-6 polyunsaturated fattyacids, cholesterol, meat, eggs or dairy products was not evidentlyrelated to either outcome for asthma. CONCLUSION: Our results

suggestthat fish consumption and the high ratio of n-3 to n-6 polyunsaturatedfatty acid intake may be associated with a reduced prevalence ofasthma in young female Japanese adults.BMC Complement Altern Med. 2006 Jul 19;6:26.Click here to read Clickhere to read Links------------Treating asthma with omega-3 fatty acids: where is the evidence? Asystematic review.------------ -Reisman J, Schachter HM, Dales RE, Tran K, Kourad K, D,Sampson M, on A, Gaboury I, Blackman J.Department of Pediatrics, Children's Hospital of Eastern Ontario,Ottawa, ON, Canada. jreismancheo (DOT) on.caBACKGROUND: Considerable interest exists in the potentialtherapeutic value of dietary supplementation with the omega-3 fattyacids. Given the interplay between pro-inflammatory omega-6 fattyacids, and the less pro-inflammatory omega-3

fatty acids, it has beenthought that the latter could play a key role in treating orpreventing asthma. The purpose was to systematically review thescientific-medical literature in order to identify, appraise, andsynthesize the evidence for possible treatment effects of omega-3fatty acids in asthma. METHODS: Medline, Premedline, Embase, CochraneCentral Register of Controlled Trials, CAB Health, and, DissertationAbstracts were searched to April 2003. We included randomizedcontrolled trials (RCT's) of subjects of any age that used any foodsor extracts containing omega-3 fatty acids as treatment or preventionfor asthma. Data included all asthma related outcomes, potentialcovariates, characteristics of the study, design, population,intervention/ exposure, comparators, and co interventions. RESULTS: TenRCT's were found pertinent to the present report. CONCLUSION: Giventhe largely inconsistent picture

within and across respiratoryoutcomes, it is impossible to determine whether or not omega-3 fattyacids are an efficacious adjuvant or monotherapy for children oradults. Based on this systematic review we recommend a largerandomized controlled study of the effects of high-dose encapsulatedomega-3 fatty acids on ventilatory and inflammatory measures of asthmacontrolling diet and other asthma risk factors. This review waslimited because Meta-analysis was considered inappropriate due tomissing data; poorly or heterogeneously defined populations,interventions, intervention- comparator combinations, and outcomes. Inaddition, small sample sizes made it impossible to meaningfully assessthe impact on clinical outcomes of co-variables. Last, few significanteffects were found.>> Michele,> > What other products do you know of that we should be wary of. Do youthink people could have sensitivities to treated tap water (e.g.fluoride, chlorine etc). > > Thanks> > BOB> > > > Omega 3's.> > > There is still some concern about those with aspirin sensitivity andomega 3's. > > When plugging in flaxseed oil and aspirin sensitivity I got this:> "Asthmatics who are sensitive to aspirin should not take omega-3oils because they may intensify their sensitivity. "> > I know that most people with asthma react

positively to omega 3's. But I do think we have to monitor our own reactions individually.>

September 19, 2008

Basically, aspirin is pinned as a Chief Inflammatory Agent. And yet in our bodies... it contradicts that.

So with anything else that says this is a good anti-inflammatory agent... we need to be cautious.

I would love to believe fish oils would help me. But I can't. I've tried them... and they haven't. I've tried so many things... and I've researched so much. Eating is killing me. I use to love to eat, I now go to the grocery store and can't stand to look at all the chemicals, etc.

The bottom line is that WE need to know our bodies more than any research out there. WE need to question what they say.

I believe, WE have more information about this than any scientist out there. WE give them our power.... and in doing so .... years go by... and WE suffer.

Pay attention. Share what you can. And let others.... do so as well.....

Maybe WE shouldn't leave it to them to solve this. I believe WE, in our very reactions, hold the key.

Michele

From: asfyso <asfyso (DOT) fr>Subject: Re: Omega 3's.samters@groups .comDate: Thursday, September 18, 2008, 5:47 PM