Re: New Zealand green lipped mussel

[Guest guest]

This is fascinating and exciting! Wouldn't it be amazing if a real cure was out there somewhere! It is heartening to know research is being done that may help or even cure us one day. Thanks for finding this, .

Becky

From: damianodavid <damianodavid@...>samters Sent: Sat, 27 August, 2011 23:10:13Subject: New Zealand green lipped mussel

Has anyone tried or heard of green-lipped mussels?It seems that green-lipped mussels contain a unique combination of fatty acids that are not found in any other marine or plant life. One of these fatty acids is eicosatetraenoic acid and it appears to act as dual inhibitor of arachidonic acid oxygenation by both the cyclooxygenase (COX) and lipoxygenase pathway. To my understanding the present theory regarding Samter's is the disorder is: caused by an anomaly in the arachidonic acid cascade, which causes undue production of leukotrienes, a series of chemicals involved in the body's inflammatory response. When prostaglandin production is blocked by NSAIDS like aspirin, the cascade shunts entirely to leukotrienes, causing overproduction of LT-4 and producing the severe allergy-like effects.(wikipedia) Studies have been done with asthma (non Samter I'm assuming). Maybe I am oversimplifying the problem but it seems as if this could help in theory. Any

thoughts?-Link to company that produces New Zealand Green-Lipped Mussel (worldwide):www.lyprinol.comAbstractTreatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trialAsthma is a chronic inflammatory disease of the airways mediated, at least in part, by leukotrienes and other lipid mediators. Experimental studies have shown that lipid extract of New Zealand green-lipped mussel, Perna canaliculus, is effective in inhibiting 5?-lipoxygenase and cyclo-oxygenase pathways responsible for production of eicosanoids, including leukotrienes and prostaglandins. The aim of this study was to assess its effect on symptoms, peak expiratory flow (PEF) and hydrogen peroxide (H2O2) in expired breath condensate as a marker of airway inflammation in patients with steroid-naïve atopic asthma in a double-blind randomised, placebo-controlled clinical trial.Forty six

patients with atopic asthma received two capsules of lipid extract (Lyprinol®) or placebo b.i.d. for 8?weeks. Each capsule of lipid extract contained 50?mg ?-3 polyunsaturated fatty acids and 100?mg olive oil, whereas placebo capsules contained only 150?mg olive oil.There was a significant decrease in daytime wheeze, the concentration of exhaled H2O2 and an increase in morning PEF in the lipid extract group compared to the placebo group. There were no significant side-effects.The authors conclude that lipid extract of New Zealand green-lipped mussel may have some beneficial effect in patients with atopic asthma.Full text at:http://erj.ersjournals.com/content/20/3/596.full

[Guest guest]

Omega-3 and Omega-6 are well known to help ameliorate the symptomatology in Samter's, and many people from this group are taking omega-3 & omega-6 fatty acids supplements. The green-lipped mussels product will probably have the same benefit as taking plain omega-3 and omega-6 fatty acids or other brands from the local drug store, but it costs a lot more. http://www.lyprinol.fr/home/uploads/distribution.html. There are better resources from which to read about Samter's, one being our Files section. I posted a while back a pdf - Aspirin exacerbated respiratory disease (AERD) or Samter's Triad which is a very good read if you want to familiarize yourself with the pathophysiology of Samter's, not that that I say that what you can read on wikipedia is bogus, but the info posted there is often incomplete and inexact, everyone can edit it.Regards,SergiuFrom: damianodavid <damianodavid@...>samters Sent: Sunday, August 28, 2011 1:10 AMSubject: New Zealand green lipped mussel

Has anyone tried or heard of green-lipped mussels?It seems that green-lipped mussels contain a unique combination of fatty acids that are not found in any other marine or plant life. One of these fatty acids is eicosatetraenoic acid and it appears to act as dual inhibitor of arachidonic acid oxygenation by both the cyclooxygenase (COX) and lipoxygenase pathway. To my understanding the present theory regarding Samter's is the disorder is: caused by an anomaly in the arachidonic acid cascade, which causes undue production of leukotrienes, a series of chemicals involved in the body's inflammatory response. When prostaglandin production is blocked by NSAIDS like aspirin, the cascade shunts entirely to leukotrienes, causing overproduction of LT-4 and producing the severe allergy-like effects.(wikipedia) Studies have been done with asthma (non Samter I'm assuming). Maybe I am oversimplifying the problem but it seems as if this could help in theory. Any thoughts?

-

Link to company that produces New Zealand Green-Lipped Mussel (worldwide):

www.lyprinol.com

Abstract

Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial

Asthma is a chronic inflammatory disease of the airways mediated, at least in part, by leukotrienes and other lipid mediators. Experimental studies have shown that lipid extract of New Zealand green-lipped mussel, Perna canaliculus, is effective in inhibiting 5?-lipoxygenase and cyclo-oxygenase pathways responsible for production of eicosanoids, including leukotrienes and prostaglandins. The aim of this study was to assess its effect on symptoms, peak expiratory flow (PEF) and hydrogen peroxide (H2O2) in expired breath condensate as a marker of airway inflammation in patients with steroid-naïve atopic asthma in a double-blind randomised, placebo-controlled clinical trial.

Forty six patients with atopic asthma received two capsules of lipid extract (Lyprinol®) or placebo b.i.d. for 8?weeks. Each capsule of lipid extract contained 50?mg ?-3 polyunsaturated fatty acids and 100?mg olive oil, whereas placebo capsules contained only 150?mg olive oil.

There was a significant decrease in daytime wheeze, the concentration of exhaled H2O2 and an increase in morning PEF in the lipid extract group compared to the placebo group. There were no significant side-effects.

The authors conclude that lipid extract of New Zealand green-lipped mussel may have some beneficial effect in patients with atopic asthma.

Full text at:

http://erj.ersjournals.com/content/20/3/596.full

[Guest guest]

We just bought Moxxor (green lipped mussel & grapeseed extract combo). We are going to give is try beginning September to see if it has any effect on Samters and/or diabetes symptoms. Will keep you posted.

[Guest guest]

Yea keep us updated! To my understanding Fish oil is rich in DHA

(docosahexaenoic acid) and EPA (eicosapentaenoic acid). While Green lipped

mussels are also rich in DHA and EPA. What makes then unique is that they're a

potent source of a rare omega-3 fatty acid called Eicosatetraenoic Acid (ETA).

While it makes logical sense that fish oil would reduce samter symptoms (and

for many people I'm sure it does) the only study I've found pertaining to fish

oil and Samter shows it could make it worse. While I have taken fish oil without

any negative (or positive) effects the conclusion of the study was that the

omega-3 in fish oil block cyclooxygenase in a way similar to aspirin and can

make asthma worse. Keep this in mind and alert your Dr. of any problems or

changes in your health.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1020748/

Thorax. 1988 February; 43(2): 93–97.

PMCID: PMC1020748

Effects of a fish oil enriched diet on aspirin intolerant asthmatic patients: a

pilot study.

C Picado, J A Castillo, N Schinca, M Pujades, A Ordinas, A Coronas, and A

Agusti-Vidal

Servei de Pneumologia, Hospital Clinic, Facultad de Medicina, Barcelona, Spain.

Abstract

The effect of a fish oil enriched diet containing about 3 g of eicosapentaenoic

acid was studied in 10 patients with aspirin intolerant asthma. Subjects were

studied during six weeks on a control diet followed by six weeks on the fish oil

diet in a single blind study design. They were asked to record their peak

expiratory flow (PEF) twice daily, bronchodilator and steroid doses, and

subjective ratings of pulmonary symptoms on diary cards. There were no

significant changes in symptom scores over the six weeks of either the control

diet or the fish oil diet. PEF values, however, were significantly lower during

the fifth and sixth week of the fish oil diet than during the control diet (308

v 262 l/min week 5 and 306 v 256 l/min week 6). Bronchodilator usage was also

greater during the fifth and sixth week of the fish oil diet than during the

control period (12.0 v 7.4 and 13.0 v 7.4 puffs a day in weeks 5 and 6). This

pilot study suggests that fish diets may have a DELETERIOUS EFFECT on patients

with aspirin intolerant asthma.

>

> We just bought Moxxor (green lipped mussel & grapeseed extract combo).  We are

going to give is try beginning September to see if it has any effect on Samters

and/or diabetes symptoms.  Will keep you posted.

>