An AERD prevalence study in Turkey

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Prevalence of

aspirin-exacerbated respiratory disease in patients with asthma in Turkey: A

cross-sectional survey.

Bavbek S, Yılmaz

I, Celik G, Aydın O, Erkekol FO, Orman A, Kurt E, Ediger D, Dursun B, Abadoğlu

O, OzÅŸeker F, Akkaya E, Karakış GP, Canbakan S, Yüksel S, Mısırlıgil Z.

SourceAnkara

University, School of Medicine, Department of Chest Diseases, Division of Immunology

and Allergy, Ankara, Turkey.

Abstract

BACKGROUND: There

are no country-based data focused on aspirin (ASA)-exacerbated respiratory

disease (AERD) in Turkey.

OBJECTIVE: To

assess the prevalence of AERD in adult patients with asthma.

METHODS: A structured

questionnaire was administered via face-to-face interview by a specialist in

pulmonology/allergy at seven centres across Turkey.

RESULTS: A total

of 1344 asthma patients (F/M: 1081/263: 80.5%/19.5%, mean age: 45.7±14.2 years)

were enrolled. Atopy rate was 47%. Prevalence of allergic rhinitis, chronic

rhinosinusitis/rhinitis, and nasal polyposis (NP) were 49%, 69% and 20%,

respectively. Of 270 patients with NP, 171 (63.3%) reported previous nasal

polypectomy and 40 (25%) had a history of more than three nasal polypectomies.

Aspirin hypersensitivity was diagnosed in 180 (13.6%) asthmatic patients, with

a reliable history in 145 (80.5%), and oral ASA provocation test in 35 (19.5%)

patients. Clinical presentations of ASA hypersensitivity were respiratory in

76% (n=137), respiratory/cutaneous in 15% (n=27), and systemic in 9% (n=16) of

the patients. Multivariate analysis indicated that a family history of ASA

hypersensitivity (p: 0.001, OR: 3.746, 95% CI: 1.769-7.929), history of chronic

rhinosinusitis/rhinitis (p: 0.025, OR: 1.713, 95% CI: 1.069-2.746) and presence

of NP (p<0.001, OR: 7.036, 95% CI: 4.831-10.247) were independent predictors

for AERD.

CONCLUSION: This

cross-sectional survey showed that AERD is highly prevalent among adult

asthmatics and its prevalence seems to be affected by family history of ASA

hypersensitivity, history of rhinosinusitis and presence of NP.