Re: Gleevec Rash

[Guest guest]

At 08:49 PM 3/13/05 -0500, Zavie wrote:

>I thought that I had the Gleevec prickly rash for a long time. I saw my

>dermatologist last week. Hadn't been there in a couple of years. I have had

>psoriasis in the past. Severe enough to develop into psoriatic arthritis.

>The psoriasis has been in check for the past 4 years.

>

>The dermatologist said that what I had was small cell Guttate Psoriasis and

>it was not drug related. I explained that I was taking Gleevec. She had not

>heard of the drug. I explained that one of the side effects was a pin point

>prickly rash.

>

>Zavie

>___________________

Hi Zavie,

I can't give you information about any articles on Gleevec rash....

might

have one on her list???

but I did want to share some info on a couple comments that you made above:

I also have a hx of chronic psoriasis......and it is much better on IM.

They now

know the reason for this. It has been confirmed that IM suppresses T-cells and

T-cells trigger the psoriasis. Psoriasis is an auto-immune skin disease.

The type of psoriasis I have always had is guttate. It is also called 'tear

drop "

psoriasis, because it is little small areas and not the usual large areas

that you

see with plaque type psoriasis. When you have one type of psoriasis, it can

convert to another type. When I first started on Gleevec and had a rash, we

did

not know for sure if it was just psoriasis or an allergic reaction to

Gleevec. We

actually did a skin biopsy for Dr. Druker to confirm that some of it was an

allergic reaction to IM.

One way to try to tell which this is...is to scrape it with something.

Psoriasis

is a too rapid build-up of skin cells and you will actually be able to

scrape them

off....some say they look silvery. Also, areas of psoriasis have increased

circulation and they bleed easily when scraped. (Of course, fragile IM skin

also

bleeds pretty easily).

Maybe the good news is that either should respond well to some cortisone

ointment (I listed a product on my earlier post to ). So, maybe you don't

need to know which it is??? same remedy.

Maui Nanc

[Guest guest]

Hi Zavie, It's interesting that you bring this topic up because I

have been experiencing a weird skin thing too.

Although I've never had psoriasis, I have had acne issues in my

life. I still get minor breakouts now, but since being on Gleevec,

I've been getting small, almost goosebump looking " acne " type bumps

on my arms and shoulders/back. Nowhere else.

At first, I thought it was a reaction to a new bath product or

clothes washing detergent, but I've switched products and the problem

still exists.

I don't know what it is.

Sincerely, Lynn

> Hi all,

>

> Could someone point me to a paper that discuses the Gleevec rash?

>

> I am looking for something that discusses what it is from s

dermatological

> point of view.

>

> I thought that I had the Gleevec prickly rash for a long time. I

saw my

> dermatologist last week. Hadn't been there in a couple of years. I

have had

> psoriasis in the past. Severe enough to develop into psoriatic

arthritis.

> The psoriasis has been in check for the past 4 years.

>

> The dermatologist said that what I had was small cell Guttate

Psoriasis and

> it was not drug related. I explained that I was taking Gleevec. She

had not

> heard of the drug. I explained that one of the side effects was a

pin point

> prickly rash.

>

> Zavie

[Guest guest]

I was having a rash on my chest about six months ago and when I

asked my ONC about it he suggested that I change to an anti-

bacterial soap and to use unscented fabric softner in the clothes

dryer. Can't say that I'm cured but it has mostly disappeared and

the " itch " certainly has gone away.

H.

dxd 2/03

Gleevec 3/03

PCR-U 6/03

> > Hi all,

> >

> > Could someone point me to a paper that discuses the Gleevec rash?

> >

>I explained that one of the side effects was a

> pin point

> > prickly rash.

> >

> > Zavie