Re: Re: basophils/Amy/A related question

[Guest guest]

Ok. Last week I was told that I had 3% interphase cells. Is that the same as

basophils? My doc upped my dosage from 600 mg Gleevec to 800 mg where I was

before.

L.

[ ] Re: basophils/Amy

Tracey,

Dr. Kantarjian said it is possible that it may be nothing but he was

definitely concerned. My absolute basophil count was 17. My

percentage was 2%. They talked about the BMS trial and what it would

entail for me to be a part of it. They said to wait for the results

and we would proceed from there. He said since my basophils had been

at " 0 " that the increase is significant. Thats all I know right

now. But when I get more information I'll let you know. My

eosinophil count was elevated as well but he didn't say anything

about that. WBC's, PLT and Hemoglobin all with in normal limits.

Thats all I know for now.

Amy

> > Hey everyone! I'm home. I had my appointment with Dr.

Kantarjian

> > yesterday and my BMA. Not the best experience to date. Two dry

> bma

> > draws, didn't start my visit off right. Third one worked, now

w/o

> my

> > shedding some tears <I just hate that> Saw Dr. K and he was

> concerned

> > because my Basophils are now at 2% from 0, which he said 'COULD'

> mean

> > my phillies are coming back or are up. I should have the BMA

> results

> > in two weeks and we will decide at that time which course to

> take. He

> > gave me a couple of options........1. We could raise my dose on

> > Gleevec, as I only take 400mg, and have for the last two years.

He

> is

> > concerned about the increased side effects, since I have a

> difficult

> > time now. 2. I could go on the Phase II trail of BMS 3. AMN107

> > Trial. Now with either of the last two options I have to be in

> Houston

> > for a minimum of 1 month, and then be there once monthly there

> after.

> > I can do that. Anyway thats my news and my choices. I don't

know

> much

> > about the AMN107, except that it is by Novartis. Anyone have

more

> > details? Thanks for listening!

> >

> > Amy B.

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[Guest guest]

Thanks Tracey,

I've always had a zero fish so this was considered to be a significant increase.

I also asked Dr. Goldman about it but he didn't say anything about changing to a

trial drug either. I'm seeing him again Sept. 2nd though. He also performed a

qpcr so that information will be helpful, too. Also, I'm getting a BMB next

Monday.

Thanks!

[ ] Re: basophils/Amy/A related question

Hi ,

From what I understand (and remember from biology class), the

term " interphase cells " refers to a particular part of the cell

cycle.....in other words it describes a part of the life of a cell

as it divides through the various stages....Gap 0, Gap 1, Synthesis

and Gap 2 are all part of the interphase cycle. Whereas a basophil

is a particular type of cell.

You would know what percentage of basophils you had from a simple

CBC but you would need to have a FISH to see how many cells are in

the interphase cycle...I'm not sure what percentage are supposed to

be in the interphase cycle so I can't tell you if 3% is high or low

or normal...sorry.

Tracey

> > > Hey everyone! I'm home. I had my appointment with Dr.

> Kantarjian

> > > yesterday and my BMA. Not the best experience to date. Two

dry

> > bma

> > > draws, didn't start my visit off right. Third one worked,

now

> w/o

> > my

> > > shedding some tears <I just hate that> Saw Dr. K and he was

> > concerned

> > > because my Basophils are now at 2% from 0, which he

said 'COULD'

> > mean

> > > my phillies are coming back or are up. I should have the

BMA

> > results

> > > in two weeks and we will decide at that time which course to

> > take. He

> > > gave me a couple of options........1. We could raise my dose

on

> > > Gleevec, as I only take 400mg, and have for the last two

years.

> He

> > is

> > > concerned about the increased side effects, since I have a

> > difficult

> > > time now. 2. I could go on the Phase II trail of BMS 3.

AMN107

> > > Trial. Now with either of the last two options I have to be

in

> > Houston

> > > for a minimum of 1 month, and then be there once monthly

there

> > after.

> > > I can do that. Anyway thats my news and my choices. I

don't

> know

> > much

> > > about the AMN107, except that it is by Novartis. Anyone

have

> more

> > > details? Thanks for listening!

> > >

> > > Amy B.

>

>

>

>

>

> -------------------------------------------------------------------

-----------

>

[Guest guest]

Thanks, Amy. I'm still baffled but am getting a BMB Monday and am waiting for

results of a qpcr done last week. All that information together should be

helpful.

L

[ ] Re: basophils/Amy/A related question

Interphase cells are on a much more cytogenic level than Basophils,

from what I read. I asked Dr. K about the increase in Gleevec and he

said he would rather go to one one trial medications. Due to the side

effects. Basophils are one of the components of the WBC, and show up in

a CBC/Differential.

http://www.funpecrp.com.br/gmr/year2002/vol2-1/gmr0013_full_text.htm

This is where I read about interphase cells.

------------------------------------------------------------------------------

[Guest guest]

Amy, Thank you also for the hyperlink. Some of it is above my noggin but it was

helpful.

[ ] Re: basophils/Amy/A related question

Interphase cells are on a much more cytogenic level than Basophils,

from what I read. I asked Dr. K about the increase in Gleevec and he

said he would rather go to one one trial medications. Due to the side

effects. Basophils are one of the components of the WBC, and show up in

a CBC/Differential.

http://www.funpecrp.com.br/gmr/year2002/vol2-1/gmr0013_full_text.htm

This is where I read about interphase cells.

------------------------------------------------------------------------------

[Guest guest]

Hi Tracey and ,

Just to clarify this a bit--when you have interphase FISH done it is

done on interphase cells only. It only looks at cells in the interphase

cell cycle. Among those cells it looks to see what percent are normal

and what percent have the bcr-abl gene. So the 3% is really not how

many were in the interphase cycle it's how many were cml vs. normal

cells. --there is always a false positive number for a FISH test

so you should ask what that number is at your lab. The false positive

is typically 1%-7% or so and if you are at or below the false positive

number for the lab you are considered negative (or at best they don't

really know for sure whether or not they have found any cml cells). I

hope this helps.

Best wishes,

Dorothy

Tracey wrote:

> Hi ,

>

> >From what I understand (and remember from biology class), the

> term " interphase cells " refers to a particular part of the cell

> cycle.....in other words it describes a part of the life of a cell

> as it divides through the various stages....Gap 0, Gap 1, Synthesis

> and Gap 2 are all part of the interphase cycle. Whereas a basophil

> is a particular type of cell.

>

> You would know what percentage of basophils you had from a simple

> CBC but you would need to have a FISH to see how many cells are in

> the interphase cycle...I'm not sure what percentage are supposed to

> be in the interphase cycle so I can't tell you if 3% is high or low

> or normal...sorry.

>

> Tracey

>

>

>

> > > > Hey everyone! I'm home. I had my appointment with Dr.

> > Kantarjian

> > > > yesterday and my BMA. Not the best experience to date. Two

> dry

> > > bma

> > > > draws, didn't start my visit off right. Third one worked,

> now

> > w/o

> > > my

> > > > shedding some tears <I just hate that> Saw Dr. K and he was

> > > concerned

> > > > because my Basophils are now at 2% from 0, which he

> said 'COULD'

> > > mean

> > > > my phillies are coming back or are up. I should have the

> BMA

> > > results

> > > > in two weeks and we will decide at that time which course to

> > > take. He

> > > > gave me a couple of options........1. We could raise my dose

> on

> > > > Gleevec, as I only take 400mg, and have for the last two

> years.

> > He

> > > is

> > > > concerned about the increased side effects, since I have a

> > > difficult

> > > > time now. 2. I could go on the Phase II trail of BMS 3.

> AMN107

> > > > Trial. Now with either of the last two options I have to be

> in

> > > Houston

> > > > for a minimum of 1 month, and then be there once monthly

> there

> > > after.

> > > > I can do that. Anyway thats my news and my choices. I

> don't

> > know

> > > much

> > > > about the AMN107, except that it is by Novartis. Anyone

> have

> > more

> > > > details? Thanks for listening!

> > > >

> > > > Amy B.

> >

> >

> >

> >

> >

> > -------------------------------------------------------------------

> -----------

> >