Guest guest Posted March 28, 2005 Report Share Posted March 28, 2005 Hello Everyone, For those of you that did not see my post previously regarding my PCR that was done by PB at Labcorp recently, I will re-post those results with my new ones from my BMBA Labcorp PCR by PB Date 2-25-05 = Positive (first time I ever had them done there) B2A2 0.005 B3A2 0.022 Genzyme PCR by BMA Date 3-14-05 = Negative (All Test done there since first DX 5-2000) ***However, last years (March of 2004) PCR results from Genzyme BMA test did show a SLIGHT positive in Major E14A2.0.005 After last years result showed a slight positive my Doctor and I were concerned that we could possibly start seeing an upward trend. With that I went back to Moffitt Cancer Center here in Tampa Fl so that in the event of a trend, I would already be registered as a patient and have easy access to the new trial drugs available. The PCR results from their laboratory- (not sure which one they use) were negative. They checked it every other month last year to see if there were any changes and all of them were negative. But again I am not sure which Lab they use right now. I just know it's not Labcorp because Dr. List indicated that he had made that change when he came on board. (they use to use labcorp) These conflicting results have caused me some confusion to say the least. Per my last past on this topic, I understand Zavie and I have both been going to different labs and getting different results. Because I am one of those people who prefer to have my glass 3/4 full, I prefer to choose the negative results! ***My question still remains: Do we assume a false positive is correct or a False negative And how do we know which one is false? I know the answer that I prefer and choose to believe, but scientifically, which one is correct????? M Tampa Fl Dx 5-2000 Hyd/int/arc 6-2001 Gleevec 400 mgs 8-2001 PCRU STILL PCRU! ZAVIE'S # 111 --- Outgoing mail is certified Virus Free. Checked by AVG anti-virus system (http://www.grisoft.com). Version: 6.0.859 / Virus Database: 585 - Release Date: 2/14/2005 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 28, 2005 Report Share Posted March 28, 2005 Yes, this is a big problem. I also have had different results from different labs, negative by Quest but positive by MD . My doctor at UCSF said he trusted the MD test more. At this point, I would only have confidence with PCR results from major CML research centers such as OHSU, MDACC, Fred Hutchinson, and UCLA. After all, the diagnostic value of the PCR scores comes from the studies that correlate them with clinical outcomes, and those studies are done by the centers such as the above. ho -------------------------------------------------------- ***My question still remains: Do we assume a false positive is correct or a False negative And how do we know which one is false? I know the answer that I prefer and choose to believe, but scientifically, which one is correct????? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 29, 2005 Report Share Posted March 29, 2005 Hi , Like you I prefer to go to the labs that tell me I'm PCRU. Who needs the other guys? It is not a question of 'false positive' like FISH tests or 'false negative'. It has to do with the sensitivity of the testing. In fact, you can have a test that is so sensitive it will detect CML among the normal healthy population. We know that Gleevec is not a cure, so until something else comes along we have to keep taking it. What is important is that you have achieved a 3 log reduction with your CML. It seems that if you have achieved this level, then there is not much of a chance that you will ever (10-20 years) relapse. The trick is to find a lab that does a very sensitive QPCR test and keeps on doing the same test. Then you will have the ability to compare results. Chances are any signs of relapse will been seen in the PB PCR test long before it appears in a BMB test. I have been told that Canada, with the help of Novartis, have standardized the Q PCR test in 7 laboratories across the country. Theoretically you should be able to send a sample to any or all of the 7 labs and get the same result. This testing is provided free of charge by Novartis Canada. I had one done on November 25, 2004 and it came back 0.012%. Had another one done on March 8, 2005. Will let you know when the results come in. I'm not sure I didn't like it better when the results came back as PCRU. Zavie [ ] New PCR results from BMA Hello Everyone, For those of you that did not see my post previously regarding my PCR that was done by PB at Labcorp recently, I will re-post those results with my new ones from my BMBA Labcorp PCR by PB Date 2-25-05 = Positive (first time I ever had them done there) B2A2 0.005 B3A2 0.022 Genzyme PCR by BMA Date 3-14-05 = Negative (All Test done there since first DX 5-2000) ***However, last years (March of 2004) PCR results from Genzyme BMA test did show a SLIGHT positive in Major E14A2.0.005 After last years result showed a slight positive my Doctor and I were concerned that we could possibly start seeing an upward trend. With that I went back to Moffitt Cancer Center here in Tampa Fl so that in the event of a trend, I would already be registered as a patient and have easy access to the new trial drugs available. The PCR results from their laboratory- (not sure which one they use) were negative. They checked it every other month last year to see if there were any changes and all of them were negative. But again I am not sure which Lab they use right now. I just know it's not Labcorp because Dr. List indicated that he had made that change when he came on board. (they use to use labcorp) These conflicting results have caused me some confusion to say the least. Per my last past on this topic, I understand Zavie and I have both been going to different labs and getting different results. Because I am one of those people who prefer to have my glass 3/4 full, I prefer to choose the negative results! ***My question still remains: Do we assume a false positive is correct or a False negative And how do we know which one is false? I know the answer that I prefer and choose to believe, but scientifically, which one is correct????? M Tampa Fl Dx 5-2000 Hyd/int/arc 6-2001 Gleevec 400 mgs 8-2001 PCRU STILL PCRU! ZAVIE'S # 111 --- Outgoing mail is certified Virus Free. Checked by AVG anti-virus system (http://www.grisoft.com). Version: 6.0.859 / Virus Database: 585 - Release Date: 2/14/2005 Quote Link to comment Share on other sites More sharing options...
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