Re: New options for patients with CML

[Guest guest]

In a message dated 9/12/2005 7:08:29 P.M. Eastern Daylight Time,

kisocean@... writes:

explore.

Dasatinib (BMS-354825) is a kinase inhibitor, and is 300 to 1000 times

more potent than imatinib (gleevec) for inhibition of bcr-abl tyrosine

kinase. Dasatinib is also an SRC inhibitor as well as an abl

inhibitor. Dasatinib is orally bio-available and can be taken as an

I was wondering about something. First, if BMS is greater than Gleevec, how

come there are fewer side effects reported? And, I know we all hated taking

IFN by injection. But I had a thought: has anyone taken Gleevec intravenously,

by injection??? I am wondering if it would be better for those with

stomach irritation due to Gleevec being taken by mouth. Think it would be an

option? The beauty of Gleevec is that we can take it orally, but just

wondering if

it has ever been administered other ways.- Lynne A.

[Guest guest]

At 05:49 PM 9/13/05 -0400, you wrote:

>I was wondering about something. First, if BMS is greater than Gleevec, how

>come there are fewer side effects reported? And, I know we all hated taking

>IFN by injection. But I had a thought: has anyone taken Gleevec

>intravenously,

>by injection??? I am wondering if it would be better for those with

>stomach irritation due to Gleevec being taken by mouth. Think it would be an

>option? The beauty of Gleevec is that we can take it orally, but

>just wondering if

>it has ever been administered other ways.- Lynne A.

Hi Lynne,

Here is the reason....as discussed with Dr. Druker.

BMS is a more potent drug.....so you need less of it, and therefore have

fewer side effects.

For example......I am taking 800mg of IM a day......and someone on BMS

might be taking 140mg (or even less)........so much less drug to cause side

effects.

BUT, because the drug is stronger, it affects the blood more........and if

you follow those on phase 2 on Jerry's site you will see that many of them

are dealing with crashing blood counts at the dose for that trial, and

needing to decrease the dose.

so, stronger drug but smaller dose = more blood effects but fewer side effects

and NO.......Gleevec is not available as an injectable....

they worked really hard to make it something people could take by mouth and

not have to inject

because they thought that that was more acceptable to people who needed a

long term drug

How are you doing?

Maui Nanc