Re: Now glut cream- How to improve your childs auditory working memory

[Guest guest]

I haven't used the Glut cream with him. We've added Reduced L-Glut (in powder form) when there's a cold going around or something like that. I read some studies that showed that Glut helped tremendously with the flu and the symptoms of it, so that's why we got it. We don't give it on a regular basis, but I'm sure we'll be giving it more regularly (if not everyday) now, during this winter/cold season, since some of our friends are sick alot during the winter. It has actually helped him get through or not get some colds that went around the past few months. These are the main two studies I read:

http://www.thorne.com/altmedrev/fulltext/glut.html - this one is very good and in depth

*Inhibition of influenza infection by glutathione*.

Cai J, Chen Y, Seth S, Furukawa S, Compans RW, DP.

Department of Biochemistry, Emory University School of Medicine,

Atlanta, GA 30322, USA. jcai@...

Infection by RNA virus induces oxidative stress in host cells.

Accumulating evidence suggests that cellular redox status plays an important role in regulating viral replication and infectivity. In this study, experiments were performed to determine whether the thiol antioxidant glutathione (GSH) blocked influenza viral infection in cultures of Madin-Darby canine kidney cells or human small airway epithelial cells. Protection against production of active virus particles was observed at a low (0.05-0.1) multiplicity of infection (MOI). GSH inhibited expression of viral matrix protein and inhibited virally induced caspase activation and Fas upregulation. In BALB/c mice, inclusion of GSH in the drinking water decreased viral titer in both lung and trachea homogenates 4 d after intranasal inoculation with a mouse-adapted influenza strain A/X-31. Together, the data suggest that the thiol antioxidant GSH has an anti-influenza activity in vitro and in vivo. Oxidative stress or other conditions that deplete GSH in the epithelium of the oral, nasal, and upper airway may, therefore, enhance susceptibility to influenza infection.

Qadoshyah

*Got Down Syndrome?

www.gotdownsyndrome.net

From: Down Syndrome Treatment [mailto:Down Syndrome Treatment ] On Behalf Of Carol in ILSent: Sunday, November 26, 2006 12:13 PMDown Syndrome Treatment Subject: Now glut cream- How to improve your childs auditory working memory

Ya, I do know what you mean LOL I was very happy to discover our pharmacy also has an alternative med data base for looking up drug interactions and side effects for common alternative remedies... I think that that lowers me just a bit on the whack-o-meter with them. ;-)

Here is where I get the glut cream -

http://www.kirkmanlabs.com/products/antioxidant/l-glutathione/LGlutathione_Lotion_Spec226.html

Q, this reminds me, what did you read that prompted you to add this to your brother's supplements? I know at first you weren't too sure about it. Carol in IL Mom to seven including , 6 with TOF, AVcanal, GERD, LS, Asthma, subglottal stenosis, and DS.My problem is not how I look. It's how you see me.

[DownSyndromeInfoEx change] How to improve your childs auditory working memory

Hello all,I found an interesting study explaining a very simple means of how toimprove the auditory working memory of children with DS.http://information. downsed.org/ library/periodic als/dsrp/ 07/1/025/ dsrp-07-1- 025-EN-GB- P.pdfHave a nice weekend,/Switzerlandwith Saskia, Nora-jane/5, 5yrs & /23mo/DS/ ASDII/GERD____________ _________ _________ _________ _________ __

[Guest guest]

Maybe low glutithione levels are one reason some kids get have longer and more frequent bouts of illness?

The Kirkman's cream is reduced-L as well and the reason I chose the cream over the oral was reports on the ASD list that levels didn't seem to go up with the oral due to the gut destroying it, so transdermal was thought to be better as it went directly into the blood stream. Carol in IL Mom to seven including , 6 with TOF, AVcanal, GERD, LS, Asthma, subglottal stenosis, and DS.My problem is not how I look. It's how you see me.

[DownSyndromeInfoEx change] How to improve your childs auditory working memory

Hello all,I found an interesting study explaining a very simple means of how toimprove the auditory working memory of children with DS.http://information. downsed.org/ library/periodic als/dsrp/ 07/1/025/ dsrp-07-1- 025-EN-GB- P.pdfHave a nice weekend,/Switzerlandwith Saskia, Nora-jane/5, 5yrs & /23mo/DS/ ASDII/GERD____________ _________ _________ _________ _________ __

[Guest guest]

Oh yeah, I definently believe that's why some kids get the flu more and have it worse.

I know, the cream is supposed to be absorbed better by the body. There's another liquid form of glutathione that's supposed to be absorbed the best - http://www.gshnow.com/ . I've heard that the oral glut doesn't cross the blood brain barrier, but I haven't heard it won't help with other processes in the body. It may not be absorbed as well, but I think it certainly helps at least some . So far, my mom, my brother (with DS) and myself are the only ones who haven't gotten the cold that all the other kids have right now . . .

Qadoshyah

*Got Down Syndrome?

www.gotdownsyndrome.net

From: Down Syndrome Treatment [mailto:Down Syndrome Treatment ] On Behalf Of Carol in ILSent: Sunday, November 26, 2006 4:17 PMDown Syndrome Treatment Subject: Re: Now glut cream- How to improve your childs auditory working memory

Maybe low glutithione levels are one reason some kids get have longer and more frequent bouts of illness?

The Kirkman's cream is reduced-L as well and the reason I chose the cream over the oral was reports on the ASD list that levels didn't seem to go up with the oral due to the gut destroying it, so transdermal was thought to be better as it went directly into the blood stream. Carol in IL Mom to seven including , 6 with TOF, AVcanal, GERD, LS, Asthma, subglottal stenosis, and DS.My problem is not how I look. It's how you see me.

[DownSyndromeInfoEx change] How to improve your childs auditory working memory

Hello all,I found an interesting study explaining a very simple means of how toimprove the auditory working memory of children with DS.http://information. downsed.org/ library/periodic als/dsrp/ 07/1/025/ dsrp-07-1- 025-EN-GB- P.pdfHave a nice weekend,/Switzerlandwith Saskia, Nora-jane/5, 5yrs & /23mo/DS/ ASDII/GERD____________ _________ _________ _________ _________ __

[Guest guest]

Qadoshyah,

you're just so resourceful - how the h.. do you manage to unearth all

this info?

I was looking up a few things on glutathione, most of which I had read

about before but had forgotten in the meantime. One thing I wasn't

able to find anymore, but is still lingering somewhere in my brain is

that supplementing with cysteine, the main glutathione precursor,

isn't supposed to be very good for people with Down Syndrome. still, I

found a study at PubMed showing the benefits of supplementing kids

with DS with Cysteine...

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

4621070 & dopt=Abstract

Do you know anything about that, or perhaps Carol??

Thanks,

>

> Oh yeah, I definently believe that's why some kids get the flu more

and have

> it worse.

>

> I know, the cream is supposed to be absorbed better by the body.

There's

> another liquid form of glutathione that's supposed to be absorbed

the best -

> http://www.gshnow.com/ <BLOCKED::http://www.gshnow.com/> . I've

heard that

> the oral glut doesn't cross the blood brain barrier, but I haven't

heard it

> won't help with other processes in the body. It may not be absorbed as

> well, but I think it certainly helps at least some . So far, my

mom, my

> brother (with DS) and myself are the only ones who haven't gotten

the cold

> that all the other kids have right now . . .

>

> Qadoshyah

> <http://www.geocities.com/gotgenetics/home.html>

> *Got Down Syndrome?

> www.gotdownsyndrome.net <http://www.gotdownsyndrome.net/>

> <http://www.geocities.com/dsinfo05/home.html>

> <http://www.geocities.com/westernsuntack>

>

> _____

>

> From: Down Syndrome Treatment

> [mailto:Down Syndrome Treatment ] On Behalf Of Carol

in IL

> Sent: Sunday, November 26, 2006 4:17 PM

> Down Syndrome Treatment

> Subject: Re: Now glut cream- How to

improve your

> childs auditory working memory

>

>

>

>

> Maybe low glutithione levels are one reason some kids get have

longer and

> more frequent bouts of illness?

>

> The Kirkman's cream is reduced-L as well and the reason I chose the

cream

> over the oral was reports on the ASD list that levels didn't seem to

go up

> with the oral due to the gut destroying it, so transdermal was

thought to be

> better as it went directly into the blood stream.

>

> Carol in IL

> Mom to seven including , 6 with TOF, AVcanal, GERD, LS, Asthma,

> subglottal stenosis, and DS.

>

> My problem is not how I look. It's how you see me.

>

>

>

> [DownSyndromeInfoEx change] How to improve your childs auditory

> working memory

>

>

>

> Hello all,

>

> I found an interesting study explaining a very simple means of how to

> improve the auditory working memory of children with DS.

>

> http://information. downsed.org/ library/periodic

>

<http://information.downsed.org/library/periodicals/dsrp/07/1/025/dsrp-07-1-

> 025-EN-GB-P.pdf> als/dsrp/ 07/1/025/ dsrp-07-1- 025-EN-GB- P.pdf

>

> Have a nice weekend,

>

> /Switzerland

> with Saskia, Nora-jane/5, 5yrs & /23mo/DS/ ASDII/GERD

>

>

>

>

>

> ____________ _________ _________ _________ _________ __

>

[Guest guest]

Hi -

Yeah, I've looked at the cysteine issue a few times, I'll get back to this email later tonight, Lord willing . . .

Qadoshyah

From: Down Syndrome Treatment [mailto:Down Syndrome Treatment ] On Behalf Of MüllerSent: Thursday, November 30, 2006 5:24 AMDown Syndrome Treatment Subject: Re: Now glut cream- How to improve your childs auditory working memory

Qadoshyah,you're just so resourceful - how the h.. do you manage to unearth allthis info?I was looking up a few things on glutathione, most of which I had readabout before but had forgotten in the meantime. One thing I wasn'table to find anymore, but is still lingering somewhere in my brain isthat supplementing with cysteine, the main glutathione precursor,isn't supposed to be very good for people with Down Syndrome. still, Ifound a study at PubMed showing the benefits of supplementing kidswith DS with Cysteine...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=14621070 & dopt=AbstractDo you know anything about that, or perhaps Carol??Thanks, >> Oh yeah, I definently believe that's why some kids get the flu moreand have> it worse.> > I know, the cream is supposed to be absorbed better by the body. There's> another liquid form of glutathione that's supposed to be absorbedthe best -> http://www.gshnow.com/ <BLOCKED::http://www.gshnow.com/> . I'veheard that> the oral glut doesn't cross the blood brain barrier, but I haven'theard it> won't help with other processes in the body. It may not be absorbed as> well, but I think it certainly helps at least some . So far, mymom, my> brother (with DS) and myself are the only ones who haven't gottenthe cold> that all the other kids have right now . . .> > Qadoshyah > <http://www.geocities.com/gotgenetics/home.html> > *Got Down Syndrome?> www.gotdownsyndrome.net <http://www.gotdownsyndrome.net/>> <http://www.geocities.com/dsinfo05/home.html> > <http://www.geocities.com/westernsuntack> > > _____ > > From: Down Syndrome Treatment > [mailto:Down Syndrome Treatment ] On Behalf Of Carolin IL> Sent: Sunday, November 26, 2006 4:17 PM> Down Syndrome Treatment > Subject: Re: Now glut cream- How toimprove your> childs auditory working memory> > > > > Maybe low glutithione levels are one reason some kids get havelonger and> more frequent bouts of illness?> > The Kirkman's cream is reduced-L as well and the reason I chose thecream> over the oral was reports on the ASD list that levels didn't seem togo up> with the oral due to the gut destroying it, so transdermal wasthought to be> better as it went directly into the blood stream.> > Carol in IL > Mom to seven including , 6 with TOF, AVcanal, GERD, LS, Asthma,> subglottal stenosis, and DS.> > My problem is not how I look. It's how you see me.> > > > [DownSyndromeInfoEx change] How to improve your childs auditory> working memory> > > > Hello all,> > I found an interesting study explaining a very simple means of how to> improve the auditory working memory of children with DS.> > http://information. downsed.org/ library/periodic><http://information.downsed.org/library/periodicals/dsrp/07/1/025/dsrp-07-1-> 025-EN-GB-P.pdf> als/dsrp/ 07/1/025/ dsrp-07-1- 025-EN-GB- P.pdf> > Have a nice weekend,> > /Switzerland> with Saskia, Nora-jane/5, 5yrs & /23mo/DS/ ASDII/GERD> > > > > > ____________ _________ _________ _________ _________ __>

[Guest guest]

Hi ,

I've done tons of searching and looking around since we found out about all the nutrition stuff. I have a file cabinet drawer full of research studies and info and I have tons of info saved in my email . I'm on lots of list too, including a couple autism research type lists and that gives lots of info!!

Onto the cysteine issue -

While supplementing with cysteine does help to raise glutathione (as it is one of the amino acids that makes up Glutathione), supplementing with n-acetyl-cysteine is the best way to go. There are a few things though . . . . Here's one abstract that shows that (note bolded part) -

Dose-dependent pharmacokinetics of acetaminophen: evidence of glutathione depletion in humans.Slattery JT, JM, Kalhorn TF, SD.The time course of excretion of acetaminophen and its metabolites in urine was determined in eight healthy adults (seven men and one woman) who ingested 1 gm of the drug and collected timed urine samples for 24 hours. The mean time of peak excretion rate was 1.3 to 3.7 hours for acetaminophen, its glucuronide, sulfate, cysteine, mercapturate, and methoxy metabolites but 13.5 hours for methylthioacetaminophen. The mean half-life of acetaminophen was 3.1 hours and the mean half-life of the metabolites other than methylthioacetaminophen ranged from 4.1 to 5.7 hours. The half-life of methylthiometabolite could not be determined because of its very late peak time. In a second study the effect of dose on the clearance of acetaminophen was determined in nine healthy adult subjects (eight men and one woman) who received doses of 0.5 and 3 gm acetaminophen on separate occasions, separated by 4 to 10 days. The renal clearance of acetaminophen and the formation clearances of the sulfate, glutathione, and catechol metabolites were lower (by 38%, 41%, 35%, and 46%, respectively) at the higher dose. The renal clearance of acetaminophen sulfate and glucuronide conjugates were not different between doses. In a third study (10 men), 10 gm N-acetylcysteine was found to increase the formation clearance of the sulfate conjugate by 27% and that of the glutathione conjugate by 10%. The data suggest that the hepatic supply of reduced glutathione and 3'-phosphoadenosine 5'-phosphosulfate begins to be depleted over the range of 0.5 to 3 gm acetaminophen and that the depletion is overcome by the administration of N-acetylcysteine.

Dr. L has observed that NAC increased OS in DS. I asked him for the info for that and he said he couldn't find it. But it was part of his own observation of patients worsening with NAC. He also said, at least in part, the reason for that would be that it converts to cysteine which already is in overabundance (typically). I'd have to agree with him on this.

I also emailed Dr. Jill on this subject and she gave me some info. She said that methylcobalamin B12 helps raise Glutathione levels. I know this is really good for DS kids as well, for their SAM cycle. Actually, when coming to think about it . . . it would make sense if methylB12 helped raise Glut levels. Since, cysteine and the methylB12 and all that are tied into the SAM cycle not functioning properly . . . hmm. I'm going to email Dr. Jill again and ask her about any studies she could refer me to where MeB12 raised glut levels. If you want to supplement cysteine, it'd be best to get an amino acid profile to see what their cysteine levels are, since it's not good to supp cysteine if it is in overabundance.

I'll forward a couple emails here that cover this subject.

Qadoshyah

*Got Down Syndrome?

www.gotdownsyndrome.net

From: Down Syndrome Treatment [mailto:Down Syndrome Treatment ] On Behalf Of MüllerSent: Thursday, November 30, 2006 5:24 AMDown Syndrome Treatment Subject: Re: Now glut cream- How to improve your childs auditory working memory

Qadoshyah,you're just so resourceful - how the h.. do you manage to unearth allthis info?I was looking up a few things on glutathione, most of which I had readabout before but had forgotten in the meantime. One thing I wasn'table to find anymore, but is still lingering somewhere in my brain isthat supplementing with cysteine, the main glutathione precursor,isn't supposed to be very good for people with Down Syndrome. still, Ifound a study at PubMed showing the benefits of supplementing kidswith DS with Cysteine...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=14621070 & dopt=AbstractDo you know anything about that, or perhaps Carol??Thanks, >> Oh yeah, I definently believe that's why some kids get the flu moreand have> it worse.> > I know, the cream is supposed to be absorbed better by the body. There's> another liquid form of glutathione that's supposed to be absorbedthe best -> http://www.gshnow.com/ <BLOCKED::http://www.gshnow.com/> . I'veheard that> the oral glut doesn't cross the blood brain barrier, but I haven'theard it> won't help with other processes in the body. It may not be absorbed as> well, but I think it certainly helps at least some . So far, mymom, my> brother (with DS) and myself are the only ones who haven't gottenthe cold> that all the other kids have right now . . .> > Qadoshyah > <http://www.geocities.com/gotgenetics/home.html> > *Got Down Syndrome?> www.gotdownsyndrome.net <http://www.gotdownsyndrome.net/>> <http://www.geocities.com/dsinfo05/home.html> > <http://www.geocities.com/westernsuntack> > > _____ > > From: Down Syndrome Treatment > [mailto:Down Syndrome Treatment ] On Behalf Of Carolin IL> Sent: Sunday, November 26, 2006 4:17 PM> Down Syndrome Treatment > Subject: Re: Now glut cream- How toimprove your> childs auditory working memory> > > > > Maybe low glutithione levels are one reason some kids get havelonger and> more frequent bouts of illness?> > The Kirkman's cream is reduced-L as well and the reason I chose thecream> over the oral was reports on the ASD list that levels didn't seem togo up> with the oral due to the gut destroying it, so transdermal wasthought to be> better as it went directly into the blood stream.> > Carol in IL > Mom to seven including , 6 with TOF, AVcanal, GERD, LS, Asthma,> subglottal stenosis, and DS.> > My problem is not how I look. It's how you see me.> > > > [DownSyndromeInfoEx change] How to improve your childs auditory> working memory> > > > Hello all,> > I found an interesting study explaining a very simple means of how to> improve the auditory working memory of children with DS.> > http://information. downsed.org/ library/periodic><http://information.downsed.org/library/periodicals/dsrp/07/1/025/dsrp-07-1-> 025-EN-GB-P.pdf> als/dsrp/ 07/1/025/ dsrp-07-1- 025-EN-GB- P.pdf> > Have a nice weekend,> > /Switzerland> with Saskia, Nora-jane/5, 5yrs & /23mo/DS/ ASDII/GERD> > > > > > ____________ _________ _________ _________ _________ __>