Re: CLL and Kidney involvement

[Guest guest]

Toby posted a note stating that his lymphoma was causing cryglobulema (inflammation of the kidneys). My initial diagnosis was CLL/SLL confirmed by a bone marrow biopsy with glomerulonephritis (confirmed by a biopsy and the fact that my 24 hour urine count was about 5000 and it was expected that my kidneys would fail), and autoimmune disease. The doctor who saw me, Dr. Bevra Hahn, head or rhumatology at UCLA said it is not unusual to have kidney or autoimmune disorders, but unusual to have both. How do these relate to CLL? I was treated with rituxan for 4 weeks the first year, cytoxin monthly for 6 months the second year and rituxan again the third year, in all cases for the kidneys. I otherwise would be a watch and wait with IVIG to boost the immune system.**************Ideas to please picky eaters. Watch video on AOL Living. (http://living.aol.com/video/how-to-please-your-picky-eater/rachel-campos-duffy/2050827?NCID=aolcmp00300000002598)

[Guest guest]

Autoimmunity (which includes glomerulonephritis some of the time) and

Immunodeficiency go hand in hand. Everyone is familar with the

immunodeficiency of CLL, but the autoimmunity is also quite

significant. Almost half of all patients will have antibodies

directed against their red blood cells (though only 20% will develop

clinical signs of hemolytic anemia). Other autoimmunity include ITP

(anti-platelet antibodies), cold agglutinin disease, and

cryoglobulinemia. The autoimmunity results from either a deficiency

of the T cells to control the B cells (in essence a T cell

deficiency) or inappropriate antigen presentation by the CLL B

cells. Both of these in essence are immunodeficiencies.

Rick Furman, MD

>

> Toby posted a note stating that his lymphoma was causing

cryglobulema

> (inflammation of the kidneys). My initial diagnosis was CLL/SLL

confirmed by a bone

> marrow biopsy with glomerulonephritis (confirmed by a biopsy and

the fact that

> my 24 hour urine count was about 5000 and it was expected that my

kidneys

> would fail), and autoimmune disease. The doctor who saw me, Dr.

Bevra Hahn, head

> or rhumatology at UCLA said it is not unusual to have kidney or

autoimmune

> disorders, but unusual to have both. How do these relate to CLL? I

was treated

> with rituxan for 4 weeks the first year, cytoxin monthly for 6

months the second

> year and rituxan again the third year, in all cases for the

kidneys. I

> otherwise would be a watch and wait with IVIG to boost the immune

system.

>

>

>

> **************

> Ideas to please picky eaters. Watch video on AOL Living.

>

> (http://living.aol.com/video/how-to-please-your-picky-eater/rachel-

campos-duffy/2050827?NCID=

> aolcmp00300000002598)

>

[Guest guest]

Please re-send Dr. Furman’s response

to this. I accidentally deleted it. Thank you.

Bonnie

From:

[mailto: ] On Behalf Of pkennedy16@...

Sent: Friday, February 29, 2008

12:46 AM

;

rrfurman@...

Subject: Re: CLL and

Kidney involvement

Toby posted a note stating that his lymphoma

was causing cryglobulema (inflammation of the kidneys). My initial diagnosis

was CLL/SLL confirmed by a bone marrow biopsy with glomerulonephritis

(confirmed by a biopsy and the fact that my 24 hour urine count was about 5000

and it was expected that my kidneys would fail), and autoimmune disease. The

doctor who saw me, Dr. Bevra Hahn, head or rhumatology at UCLA said it is not

unusual to have kidney or autoimmune disorders, but unusual to have both. How

do these relate to CLL? I was treated with rituxan for 4 weeks the first year,

cytoxin monthly for 6 months the second year and rituxan again the third year,

in all cases for the kidneys. I otherwise would be a watch and wait with IVIG

to boost the immune system.

**************

Id eas to please picky eaters. Watch video on AOL Living.

(http://living.aol.com/video/how-to-please-your-picky-eater/rachel-campos-duffy/2050827?NCID=aolcmp00300000002598)