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I have attached to this email an excert of

my last 6 months of blood work (including charts which makes easier reading). Just

in case some members feel nervous about opening the attachment, I have appended

the key numbers below:

12/08/2007

11/10/2007

23/11/2007

15/02/2008

30/03/2008

HB

14.3

13.2

14.1

12.7

12.3

12/08/2007

11/10/2007

23/11/2007

15/02/2008

30/03/2008

Whites

6.3

6.6

7.9

7.8

NK

12/08/2007

11/10/2007

23/11/2007

15/02/2008

30/03/2008

Platelets

118

125

137

104

79

12/08/2007

11/10/2007

23/11/2007

15/02/2008

30/03/2008

Neuts

3.7

3.1

3.3

3.3

NK

12/08/2007

11/10/2007

23/11/2007

15/02/2008

30/03/2008

Lymphs

1.8

3.1

4.2

4.1

2.6

I am now 25 months post Rituxan and

Chlorambucil which has served me extremely well, but symptoms have returned

over recent months. My story is somewhat complicated in that I have found

myself without a Haematologist in recent months until yesterday when I meet my

new Haematologist for the first time. She was very meticulous in her

examination of my previous history and of myself, so I feel quite confident

that I can work with her going forward. She ordered a battery of blood

tests, including CD38 and FISH to recheck my markers before any future

treatment. She even called me later in the day to say that she had taken

a look at some of my blood results and she was concerned about the failing HB

and Platelets and in view of this she has scheduled me for a more blood tests, BMB

and CT Scan. She was concerned that my CLL has transformed into something

more aggressive, or ITP, or a viral activation such as CMV.

Over the last 6 months my health has been

a little up and down, muscle and joint pains in the lower limbs, tiredness and

fatigue.

My questions is two fold, (i) do you feel

that my Haematologist is just being cautious in ordering these additional tests

and (ii) do my blood results demonstrate that something serious is going on,

other than just a marrow that’s becoming a little compacted and therefore

restricting the production of normal cell lines.

Appreciate any views you may have and

maybe Dr Furman might be able to pass comment.

Regards

UK, Bournemouth. Dx May 2000. Age 51. Oral

Fludarabine 2002. 4 weeks of Rituxan June 04 and Jan 05.

Oct 05/Feb 06 monthly Rituxan and Chlorambucil.

Trisomy 12, IgVH mutated, ZAP70 –ve, CD38 –ve.

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