Guest guest Posted October 7, 2005 Report Share Posted October 7, 2005 Hi to everyone. I have been so overwhelmed with work the last few weeks.I also had a chance to travel with my husband for a short vacation.. I want you to know though that I have been reading all your e-mails and all the valuable information provided by on Dr. Bubalo's notes and others. Congratulation to Cheryl for her 5 th anniversary. I Hate to ask for advice when I've been so lax lately, but I need some opinions. I got my QPCR results . Counts were higher than the last test. My B2A2 is less than 0.001% limit (thanks GOD) but B3A2 is now 0.045. Last time I had a reading of 0.025% for B3A2. My stubborn count of B3A2 has been fluctuating between 0.06 and 0.025 for the last 10 months. I am on 400 mg of Gleevec. I will see my doctor in two weeks. Although I know that this is still a low count but I wonder if any one had the same situation and had to increase dosage.I think this standard dose is not enough to kill all leukemia cells and achieve PCRU. Don't take me wrong, I am grateful to Gleevec/ IM for giving me hope for a better life with CML. Love and Peace to you all T dxd 1/03 CCR 7/3 Zero Club# 764 PCRU pending [ ] Dr. Bubalo, #2 Dr. Bubalo, #2 Drug Interactions * cause reduction of chemotherapeutic effects........ St. 's Wort, garlic, gingko, grape seed, Kava, nutmeg, quercitin (partial list) *chemotherapy drugs affected............ includes Gleevec, Taxol, Tamoxifen (partial list, included many familiar sounding drugs used with BMT, preconditioning and treatment) **per Dr. Bubalo, problem with St. 's Wort, it speeds up metabolism of Gleevec and it is not as effective. ____________________ some herbals or supplements increase the effects of selected chemotherapy drugs these include: echinacea, ginseng, goldenseal, grapefruit juice/seed extract, licorice, milk thistle (fruit and seed), red clover, red yeast, valerian, wild cherry ____________________ ____________________ Effects on Blood Elements **may lower platelets **may affect red blood cell production **may increase early types of blood cells **may increae the risk of bleeding when used with blood thinning agents (ie warfarin/Coudadin) Agents which may reduce platelet numbers (complete list given) *alpha lipoic acid (IV) *chromium picolinate *Gingko biloba (WHO ADR Report) *kava kava (chronic use) *L-arginine (IV) *Lentinan (shiitake mushroom component) *parsley (massive amount of volatile oil) *pokeweed *selenium *ephedra (6 cases with FDA)......banned substance Agents which may increase the effects of blood thinners (complete list given) *arnica *bilberry *Bishop's Weed *borage seed oil *bromelian *chamomile *clove *coenzyme Q-10 *danshen *dexpanthenol *Devil's Claw *Dong Quai *Fenugreek *feverfew *fish oils *garlic *ginger *gingko biloba *ginseng *green tea *horse chestnut sweet clover *IP-6 (inositol 6 hexaphosphate) *licorice *meadowsweet *onion *papain *parsley *passion flower *quassia *quinine...........which some of us use for muscle cramps *red clover *Reishi mushroom *St. 's Wort *sweet clover *tumeric *Vit E-containing herbs (ie sunflower seeds) ______________ Agents that may decrease iron absorption *black cohosh *chamomile *feverfew *hawthorn *gossypol *nettle *plantain *saw palmetto *St. 's Wort *valerian Take these 2 hours away from any iron supplements ______________ Increase early forms of blood cells (may be undesirable) *alkylglycerols (shark cartilage and shark liver oil) *melatonin __________________ Agents of concern with surgery **Stop these agents 2 weeks before surgery echinacea - affects liver function ephedra (Ma huang) - increased cardiac risk ......now banned garlic, ginkgo, ginseng - affect blood clotting St. 's Wort - decreases efficacy of anesthetics valerian - makes anesthesia unpredictable resume them when it is OK with your surgeon _____________________ next installment.....herbal safety issue, regulation of herbal industry Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2005 Report Share Posted October 7, 2005 Hi , Your PCR results are very steady. You will never get two tests that are the same and even if you tested the same sample twice, it would show different results. This is simply the nature of the test. The difference between 0.060 and 0.025 is not significant. PCR scores only become significant when they change by a full log which is not your case so I don't see any concern here. Tracey Quote Link to comment Share on other sites More sharing options...
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