Guest guest Posted September 25, 2005 Report Share Posted September 25, 2005 Hello Bill, For reasons that are not well understood, two types of fibrous tissue, collagen and reticulin, tend to build up in the bone marrow as CML progresses, replacing normal blood forming cells. The amount of fibrosis is graded from 0 to 4+, 4+ being complete replacement by fibrous tissue; hence " 2+ out of 4+ " means that your marrow is about 1/2 way there. Untreated, fibrosis can permanently harm the marrow as a blood producing organ, but fortunately the process is reversed in most patients soon after they start taking Gleevec (not so with Interferon, which is one of the reasons Gleevec is preferred to this older drug). Just out of interest, how long since your diagnosis? I believe it takes about a year on Gleevec for the fibrosis to resolve in most folks. It's not something we worry much about anymore. Regards, R > Date: Sat, 24 Sep 2005 22:02:17 -0000 > From: " wjmc5 " <wjmc5@...> > Subject: reticulin fibrosis > > I posted the message below on another message board and I didnt not > get any feedback. I thought I might try here. > > From reading the results of our first bone marrow reports I am curios > of what the Retuculin stain results mean. > > If anyone understands what is meant by " Bone marrow demonstrates > slight to mderately increased reticulin fibrosis I > would appreciate knowing the if this is normal in most cml patients. > > Thank you, Bill Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 27, 2005 Report Share Posted September 27, 2005 Hello , Thank you for your response. My wife was dx'ed in late August 2005 after normal blood work. I have been in super hyperdrive to find out as much as I possibly can for her. and I are very thankful to everyone who has been answering our questions and sending us warm thoughts and prayers. We send the same back to all of you and we pray for all the sick in the world. We do have a meeting with a BMT doctor tomorrow to disscuss her CML treatment. Bill > Hello Bill, > > For reasons that are not well understood, two types of fibrous tissue, > collagen and reticulin, tend to build up in the bone marrow as CML > progresses, replacing normal blood forming cells. The amount of fibrosis is > graded from 0 to 4+, 4+ being complete replacement by fibrous tissue; hence > " 2+ out of 4+ " means that your marrow is about 1/2 way there. > > Untreated, fibrosis can permanently harm the marrow as a blood producing > organ, but fortunately the process is reversed in most patients soon after > they start taking Gleevec (not so with Interferon, which is one of the > reasons Gleevec is preferred to this older drug). > > Just out of interest, how long since your diagnosis? I believe it takes > about a year on Gleevec for the fibrosis to resolve in most folks. It's not > something we worry much about anymore. > > Regards, > > R > > > Date: Sat, 24 Sep 2005 22:02:17 -0000 > > From: " wjmc5 " <wjmc5@y...> > > Subject: reticulin fibrosis > > > > I posted the message below on another message board and I didnt not > > get any feedback. I thought I might try here. > > > > From reading the results of our first bone marrow reports I am curios > > of what the Retuculin stain results mean. > > > > If anyone understands what is meant by " Bone marrow demonstrates > > slight to mderately increased reticulin fibrosis I > > would appreciate knowing the if this is normal in most cml patients. > > > > Thank you, Bill Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.