Re: granulocytic sarcoma/Sott and R.

[Guest guest]

> if any of you remember my leg pain complaints, well they were recently

> diagnosed after a surgical biopsy as a " Granulocytic Sarcoma " which is

> made up of normal CML type cancer cells. I have begun radiation

> treatments to get rid of the tumor and my hemotologist is now

> suggesting that I consider a SCT as a more aggressive treatment for

> the CML. I am arguing that this may not be required as I have had an

> Extremely good response with Gleevec and I feel that as the leg pain

> was present before being diagnosed with CML that the Tumor was

> probably underway before Gleevec treatment was started. If anyone has

> any experience with this please let me know, I have not seen any other

> references to this on any boards. This is not great news but much

> better than it being a sarcoma of a differnent kind of cancer so I

> will continue to be the optimist. :-)

Hi ,

I'm not a medical professional, but I think that what you have been

diagnosed with may be a chloroma. This is an excerpt from an article I

just pulled up:

A chloroma is a solid tumor composed of immature white blood cells

called myeloid precursor cells. They are most often found in acute

myelocytic leukemia (AML) but may be found in other myeloproliferative

disorders such as polycythemia vera, hypereosinophilia, and myeloid

metaplasia. Chloromas get their name from the Greek chloros (meaning

green) since these tumors often have a green tint due to the presence

of myeloperoxidase. Chloromas may be seen under the skin, around the

eyes, or in the mouth. They are often very tender. Treatment is

usually radiation therapy as chloromas are exquisitely sensitive to

low doses of radiation.

, do you have any thoughts on this?

[Guest guest]

Hi and ,

Yes, a granulocytic sarcoma is the same as a chloroma. I'm not sure, but I

believe these may suggest more advanced CML, so it's understandable that

your heme/onc would at least want to start thinking about SCT.

, at diagnosis, did you have any other hallmarks of more advanced

disease, such as a high blast or basophil count, especially high platelets

or low hemoglobin, or chromosomal abnormalities other than BCR-ABL? If not,

then I agree with you that it's may be worth continuing with IM which has

worked so well for you - especially if you're convinced that the chloroma

predated your diagnosis and the start of Gleevec. How long ago was that, by

the way? Also, how sure are you that the bone pain you had then is the same

as what brought you to the doctor recently?

Best wishes,

R

> Date: Sun, 14 Aug 2005 18:34:32 -0000

> From: " kisocean " <kisocean@...>

> Subject: Re: granulocytic sarcoma/Sott and R.

>

>

>> if any of you remember my leg pain complaints, well they were recently

>> diagnosed after a surgical biopsy as a " Granulocytic Sarcoma " which is

>> made up of normal CML type cancer cells. I have begun radiation

>> treatments to get rid of the tumor and my hemotologist is now

>> suggesting that I consider a SCT as a more aggressive treatment for

>> the CML. I am arguing that this may not be required as I have had an

>> Extremely good response with Gleevec and I feel that as the leg pain

>> was present before being diagnosed with CML that the Tumor was

>> probably underway before Gleevec treatment was started. If anyone has

>> any experience with this please let me know, I have not seen any other

>> references to this on any boards. This is not great news but much

>> better than it being a sarcoma of a differnent kind of cancer so I

>> will continue to be the optimist. :-)

>

> Hi ,

>

> I'm not a medical professional, but I think that what you have been

> diagnosed with may be a chloroma. This is an excerpt from an article I

> just pulled up:

>

> A chloroma is a solid tumor composed of immature white blood cells

> called myeloid precursor cells. They are most often found in acute

> myelocytic leukemia (AML) but may be found in other myeloproliferative

> disorders such as polycythemia vera, hypereosinophilia, and myeloid

> metaplasia. Chloromas get their name from the Greek chloros (meaning

> green) since these tumors often have a green tint due to the presence

> of myeloperoxidase. Chloromas may be seen under the skin, around the

> eyes, or in the mouth. They are often very tender. Treatment is

> usually radiation therapy as chloromas are exquisitely sensitive to

> low doses of radiation.

>

>

> , do you have any thoughts on this?