Low Dose Cytoxan

[Guest guest]

Dave:

I didn't have a specific discussion about it. I've been consulting with Dr.

Canellos at Dana Farber and it was his recommendation. I believe it was because

of the mild toxicity. I had no nausea and no hair loss. It was convenient and

pretty cheap. And it seemed to do the trick, together with Rituxan.

Toby

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[Guest guest]

About 4 years ago I went into kidney failure and had to start

treating my SLL/CLL. We used 2 rounds of rituxan a month apart and low

dose cytoxan (100 mg daily) for about 10 months. Because my kidneys

were so inflamed due to cryoglobulemia I also had high dose prednisone

thrown in at the beginning, and then tapered off over a 3 month period

of time. All in all (except for the prednisone), it was a well

tolerated treatment and put me in CR for four years. Now platelets

are dropping (142) and I'm considering whether to treat again, low

dose cytoxan and rituxan.

>

> Toby Hollander

> dx 7/99 SLL/CLL, tx w/ rituxan x2 in 2003, w/ low dose cytoxan, CR

since

>

hello everyone,

that's something I've been wondered too after my oncol suggested

cytoxan-rituxan combo as a chemo approach, if it comes to that. She

never explained why. Maybe it was because she thought I might have

autoimmune cytopenias, AIHA and ITP. Dr. Kanti Rai used C-R +steroid

(dexamethasone) in such patients, but that was no low dosage protocol.

I myself would prefer to stay away from fludara because of it's

T-cell and bone marrow toxicity. I'm leary of cytoxan too, and low

dosage sounds intriguing, but i never heard cytoxan being used this

way. Maybe Dr. Furman can comment.

Arnold

dx 7/07 cll/sll, prednisone 60 mg several months, off now