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IVIG Side Effects

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If your referring to the kid who is bouncing off the walls post infusion, you

must be speaking of Cassie. I always blame it on the dextrose that was used.

It was like getting a sugar rush without getting to enjoy it : )

But in all seriousness, Cassie does get a little more active after infusions

and it tends to last for a few days. She then is usually back to her old

self and then the last week drag comes up.

Hope all are doing well. Have a great weekend.

Belinda Rose,

Mom to Allyssa (10) and Cassie (7), igg immunodeficient, asthma, sinusitis,

IVIG for 5 years (trialing off for retesting)

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Hi Kim,

No, your son is not the only one!!! My was always like that

too after an infusion. He was always never much of an eater but when

he got an infusion, boy did he eat!!! He said it was because he felt

better. So I would have to say that the ivig was giving the body

enough of a brake from fighting off things that it gave more of the

energy that they would normally have to run around and play. My son

also would not want to be out running around with the kids but would

just sit and play with his legos and watch tv. Now he plays with the

others more willingly, could be too that he is getting older, who

knows.

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It would take an anchor to hold down the first week after IVIG.

8-)

Wenoka

At 06:44 PM 04/05/2002 -0000, you wrote:

>I was wondering how other children respond to the IVIG that first

>week. usually falls asleep during the end of the infusion, but

>he is really hyper for a few days after. Then, about a week before

>he is due again, he slows down. Not drastically, but noticable, i.e.

>naps in the afternoon when he normally doesn't. The Dr. never heard

>of any kids getting hyper after their treatment and we were the

>first. He laughed, since doesn't fit a whole lot of anything

>book wise.

>

>Just wondering if it maybe has nothing to do with the IVIG or if

>others do experience this " BOOST " of energy after treatment.

>

>Kim - Mom to Nick, (CVID) and

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Kim:

My son Blake is 10 yrs. old and he receives IVIG every 2 weekw. We

travel 2 hrs. one way for him to receive this. He is on 10 grams.

Each time he receives it, they always premedicate him with Solumedrol

(steroids) and Benadryl. We actually have stock in the company that

manufactures Benadryl(Pfizer). When we get through, I swear Blake is

a different child. He will drive you crazy. And let me tell you one

thing, he also eats like a pig after the steroids kick in. He could

care less for food at any other time of the week, but give him

Solumedrol, and boy, he wants things you could never get him to eat

at any other time. And he " bounces every where(my Tigger).

We also deal with the behavior problems that come with Solumedrol.

Because Blake has the Sensory Intergration problems and ADHD(a gift

from his prematurity) the meds. inhance the " undesired " behavior as

well as the hyperactivity. But by the Tues. before he gets his bi-

weekly infusion, you can tell he is in no mood to dispute his parents.

What I mean by this is, you would nt think he was the same child the

week before. He becomes sooooo listless and very tired. This is

also the time he starts really having problems with his breathing.

His Teacher that comes to our house can tell the difference also in

his school work. He will start yawning and become so sleepy that

when she leaves he goes to bed!! And she is only here for 1 hr.!!!!

Then Fri. comes and here comes the " Happy Juice " as Blake calls it.

He is sooooooooo ready to get the stuff that he will now sit and let

teh nurses get his IV in with out fighting. And for Blake to not

fight them, they are shocked(I think part of it is age too!).

Well gotta go. It's time to try and get the " rug-rat " to eat.

Hope all the other children are doing fine(as can be expected with

Spring hitting full bloom). I will update at a later time on

the " Adventures of Blake " as soon as I get a chance.

(mom to Blake CVID with Selective T-Cell

Dysfunction,Asperger's Syndrome,Severe Asthma

Sensory Intergrated Motor Issues and a rare

Blood disorder-Prothrombin Genetic Defect

WHEW!!!!!!!!!)

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I feel better that I am not alone regarding the " Boost " of energy my son

gets right after his treatment. When the Dr. said I was the first he ever

heard I was so shocked. If you think about it, it just makes sense that

they would get a little hyper after having the treatment - their bodies are

lacking what they need and then to have it all replenished all at once.

Especially if they are not feeling well before. And my Dr. is a pediatric

immunologist at children's hospital, so it's not like he doesn't see a lot

of kids. Chris' teacher can tell when he has his treatment. She says he is

distracted, impulsive and can't sit still. I remember a visit to Wal-Mart

right after one of our first treatments...he literally cart wheeled down the

isles. He couldn't contain his energy! It's kind of funny now, I was

mortified at the time.

Anyway, I would rather have him hyper and well - then contained and sick.

I'm sure we would all agree.

Also, when I told the Dr. that he slows down that last week, taking more

naps, etc..., he said the treatment might not be lasting the entire four

weeks (we've only been doing this since July). He is running his blood work

at it's peak and again right before the next treatment to see. He gave me

the option to go to every three weeks if I thought it was a problem or to up

his dose a little. I opted for the increased dose for now. I would rather

not go to every three weeks unless it's really necessary. He's not getting

any breakthrough infections, just gets a little tired and achy that last

week. Not enough to impact his activities, just enough that I notice it. I

know a lot of you get your treatments every 3 weeks ( and sometimes less).

Is it because of breakthrough infections or just the protocol of different

doctors. I am curious.

Thanks all for responding...

Kim - Mom to Nick 7, 5 (CVID) and 2

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Rebekah is rather hyper for about 3 days afterwards. After the very first

infusion, she ran around the house for a solid hour. We did think she even

knew HOW to run.

Pam

wife to (15 years)

mother to , 8, Hannah, 5, Rebekah 2, and Leah (5-11-2001)

IVIG Side effects

I was wondering how other children respond to the IVIG that first

week. usually falls asleep during the end of the infusion, but

he is really hyper for a few days after

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  • 4 years later...

A new article was published about IVIG side effects: Arch. Dis. Child.

2006;91;651-654; D Singh-Grewal, A Kemp and M Wong. I can't attach the article

so I'll post some of the main findings for those that are interested:

Title: Immunoglobin Infusions Adverse Events Following Intravenous: A

Prospective Study of the Immediate and Delayed

http://adc.bmjjournals.com/cgi/content/full/91/8/651

AIM: To document the incident of immediate and delayed adverse events (AEs)

following IVIG in children

METHODS: AEs were recorded for 345 infusions among 58 children with immune

deficiency. Parents were asked ¡¡Did you notice any problems after the

immunoglobulin infusion?¢¢, followed by a list of common adverse effects (fever,

headache, rash, abdominal pain, tiredness, nausea, vomiting)

RESULTS: Immediate AEs occurred in 10% and delayed adverse event in 41% of

children. Sixty nine (72.6%) of the delayed reactions occurred within 24 hours

of IVIG.

A significant number of delayed reactions occurred > 24 hours post IVIG:

10 between 24-48 hours,

6 between 48-72 hours,

10 between 72-96 hours.

CONCLUSIONS: Delayed adverse events to IVIG are common; they occure more

frequently than immediate AEs and are the cause of significant morbidity.

Recognition of delayed AEs is important in the care of children receiving IVIG

therapy.

DISCUSSION: To our knowledge this is the first study to document the high rate

of delayed AEs (20.9% of infusions and 41.4% of patients). Delayed AE were six

times more frequent than immediate reactions per patient and four times more

frequent per infusion. The previous lack of recognition of the significance of

delayed AE indicates that unless these delayed symptoms are actively sought they

are likely to be overlooked.

In conclusion, delayed AEs to IVIG are common in children and occur more

frequently than immediate AEs. They were the principal cause of lost school

time, need for additional therapies, and medical consultations in this study.

Recognition of the high frequency of delayed AEs is important in the care of

children receiving IVIG therapy.

___________________

mom to CVIDer

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this is very upsetting to me

---- Schulman <dietdoc@...> wrote:

> A new article was published about IVIG side effects: Arch. Dis. Child.

2006;91;651-654; D Singh-Grewal, A Kemp and M Wong. I can't attach the article

so I'll post some of the main findings for those that are interested:

>

> Title: Immunoglobin Infusions Adverse Events Following Intravenous: A

Prospective Study of the Immediate and Delayed

> http://adc.bmjjournals.com/cgi/content/full/91/8/651

>

> AIM: To document the incident of immediate and delayed adverse events (AEs)

following IVIG in children

>

> METHODS: AEs were recorded for 345 infusions among 58 children with immune

deficiency. Parents were asked ¡¡Did you notice any problems after the

immunoglobulin infusion?¢¢, followed by a list of common adverse effects

(fever, headache, rash, abdominal pain, tiredness, nausea, vomiting)

>

> RESULTS: Immediate AEs occurred in 10% and delayed adverse event in 41% of

children. Sixty nine (72.6%) of the delayed reactions occurred within 24 hours

of IVIG.

>

> A significant number of delayed reactions occurred > 24 hours post IVIG:

> 10 between 24-48 hours,

> 6 between 48-72 hours,

> 10 between 72-96 hours.

> CONCLUSIONS: Delayed adverse events to IVIG are common; they occure more

frequently than immediate AEs and are the cause of significant morbidity.

Recognition of delayed AEs is important in the care of children receiving IVIG

therapy.

>

> DISCUSSION: To our knowledge this is the first study to document the high

rate of delayed AEs (20.9% of infusions and 41.4% of patients). Delayed AE were

six times more frequent than immediate reactions per patient and four times more

frequent per infusion. The previous lack of recognition of the significance of

delayed AE indicates that unless these delayed symptoms are actively sought they

are likely to be overlooked.

>

> In conclusion, delayed AEs to IVIG are common in children and occur more

frequently than immediate AEs. They were the principal cause of lost school

time, need for additional therapies, and medical consultations in this study.

Recognition of the high frequency of delayed AEs is important in the care of

children receiving IVIG therapy.

> ___________________

>

>

> mom to CVIDer

>

>

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  • 11 months later...

Thanks Carol. I had heard a self injected version was available, but didn't know the name. Appreciate the link.

Ann

AlbuquerqueSee AOL's top rated recipes and easy ways to stay in shape for winter.

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I was told by a nurse in the infusion center at UCLA that IVIG has

been hard to come by and we, therefore, don't necessarily get the same

brand every time which can cause the side effects to vary. They use

tylenol and benedryl to help lessen the effects, but won't let you

drive for several hours if you take the benedryl.

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