Re: dim, weakly-expressed, etc...

[Guest guest]

CD20 dim means that there is just a lower number of molecules of CD20

on each CLL B cell compared to what is seen on normal B cells. The

CD20 molecules are not made and not put on the surface of the cell.

> >

> > I also found Dr. Furman¹s statement that all mature B cells are

> CD20+

> > interesting. According to Dr. Byrd¹s lab at Ohio State, all of my

> B cells

> > are CD19+, but only 29% of them are CD20+.

> >

> > Does this mean that only 29% of my B cells are mature? A group

> (11%) also

> > express CD79a and 3% express CD 38. The larger group, besides

> expressing

> > CD19+, also express CD22 dim+, CD5+, CD43+ and CD23+. Would this

> lack of

> > CD20+ be a counter-indication for Rituxan?

> >

> > Might the lack of CD20+ have something to do with the fact that I

> do not

> > have any of the 4 usual deletions, but I do have a 6p23 deletion

> (whose

> > significance in CLL is not known)?

> >

> > No doubt there is a lot of research still to be done....

> >

> > Thanks very much for your contributions, Dr. Furman!

> >

> > Marcia

> >

>

>

>

>

>

>

> ---------------------------------

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[Guest guest]

Now I understand. Thank you. waynerrfman <rrfurman@...> wrote: CD20 dim means that there is just a lower number of molecules of CD20 on each CLL B cell compared to what is seen on normal B cells. The CD20 molecules are not made and not put on the surface of the cell.> >> > I also found Dr. Furman¹s statement that all mature B cells are > CD20+> > interesting. According to Dr. Byrd¹s lab at Ohio State, all of my > B cells> > are CD19+, but only 29% of them are CD20+.> > > > Does this mean that only 29% of my B cells are mature? A group > (11%) also> > express CD79a and 3% express CD 38. The larger group, besides > expressing> > CD19+, also express CD22 dim+, CD5+, CD43+ and CD23+. Would this > lack of> > CD20+ be a counter-indication for Rituxan?> > > > Might the lack of CD20+ have something to do with the fact that I > do not> > have any of the 4 usual deletions, but I do have a 6p23 deletion > (whose> > significance in

CLL is not known)?> > > > No doubt there is a lot of research still to be done....> > > > Thanks very much for your contributions, Dr. Furman!> > > > Marcia> >> > > > > > > ---------------------------------> Looking for last minute shopping deals? Find them fast with Search.>

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