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Flavopiridol report: Induces Durable Responses in Relapsed CLL

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Flavopiridol (Alvocidib) Induces Durable Responses in Relapsed Chronic

Lymphocytic Leukemia (CLL) Patients with High-Risk Cytogenetic

Abnormalities

http://ash.confex.com/ash/2008/webprogram/Paper11242.html

n = 117 pts with relapsed CLL (n=107) or small lymphocytic lymphoma

(n=10) , median age 60 years, 116 pts had received prior purine analog

therapy, and 85 pts (73%) were refractory to (n=82) or intolerant of

purine analog (n=3). Ninety-three pts were Rai stage III/IV (79%), and

85 pts had bulky lymph nodes ³ 5 cm (73%).

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