Gleevec Usage Prior to Transplant and Transplant Related Mortality

[Guest guest]

I remember someone asking about Gleevec before transplant. I couldn't

remember which group posted the question, so I am posting this

information to all groups, excuse the repetition. This is an article

specifically about CML and stem cell transplants. There is also

discussion about taking Gleevec prior to transplant. The advice given

is to stop Gleevec usage 30 days prior to transplant because of liver

toxicity. Wish I would've read this sooner.

Here is a brief snippet of the article and the website:

Conference Coverage

Stem Cell Transplants for Chronic Myeloid Leukemia (CML) EBMT 2004

Date: March 28-31, 2004

Location: Barcelona, Spain

Author: C. D. Buckner, MD

Introduction

The European Group for Bone Marrow Transplantation (EBMT) held the 30th

annual meeting in Barcelona from March 28-31 2004. At this meeting

there were several presentations about the outcomes of patients

receiving allogeneic stem cell transplants for CML. All the transplant

centers have observed a 50% or greater reduction in the number of

patients transplanted for CML in the chronic phase since the

introduction of Gleevec® in 2000. Dr. Goldman of Hammersmith

Hospital, who is considered to be the world’s experts on CML, delivered

an opening address outlining the status of allogeneic stem cell

transplantation in the Gleevec® era.

http://professional.cancerconsultants.com/conference_ebmt_2004.aspx?

id=30036

Barb Neddo,

Mom to Tom,

dx CML 8/04, MUD BMT 05/05/05

http://www.caringbridge.org/wi/tomneddo