Re: Question about stromal cells, AT-101

[Guest guest]

This is one of the most interesting and productive areas of research. There are

some data emerging that the efficacy of CAL-101 and PCI-32765 are the result of

these molecules inhibiting the signals to the CLL cells from the stromal cells.

The more we work with these new agents, the more we learn about basic CLL

biology.

There has also been a great deal of difficulty culturing CLL cells in the

laboratory. The fact that this is possible with stromal cells further supports

the importance of stromal cells in CLL cell survival.

Rick Furman

>

> There has been a few research papers that suggest that stromal cells in the

bone marrow may act to protect malignant B-cells from apoptosis in their

micro-environment.

>

> So why is this approach not being studied with more vigour?

>

> Further it appears that stromal cells act to prevent purine analogue and

spontaneous apoptosis by increasing Mcl-1 levels.

>

> http://bloodjournal.hematologylibrary.org/cgi/content/full/114/20/4441

>

> In 2008 it was noted that AT-101 (gossypol) was able to overcome this.

>

> http://bloodjournal.hematologylibrary.org/cgi/content/abstract/113/1/149

>

> , Castro, Kipps et al

>

http://www.asco.org/ascov2/Meetings/Abstracts? & vmview=abst_detail_view & confID=40\

& abstractID=34951

>

> More on Gossypol:

>

http://download.journals.elsevierhealth.com/pdfs/journals/0944-7113/PIIS09447113\

08000913.pdf

>

>

> ~chris

>