Question about stromal cells, AT-101

[Guest guest]

There has been a few research papers that suggest that stromal cells in the bone

marrow may act to protect malignant B-cells from apoptosis in their

micro-environment.

So why is this approach not being studied with more vigour?

Further it appears that stromal cells act to prevent purine analogue and

spontaneous apoptosis by increasing Mcl-1 levels.

http://bloodjournal.hematologylibrary.org/cgi/content/full/114/20/4441

In 2008 it was noted that AT-101 (gossypol) was able to overcome this.

http://bloodjournal.hematologylibrary.org/cgi/content/abstract/113/1/149

, Castro, Kipps et al

http://www.asco.org/ascov2/Meetings/Abstracts? & vmview=abst_detail_view & confID=40\

& abstractID=34951

More on Gossypol:

http://download.journals.elsevierhealth.com/pdfs/journals/0944-7113/PIIS09447113\

08000913.pdf

~chris