MDACC - FCR pretreated trail

[Guest guest]

Journal Blood has published the MD FCR trial results for pretreated CLL

patients with a median age of 60yrs. (This is somewhat similar to the REACH

trail- CLL4)

It found:

The overall response rate was 74%, with 30% complete remission.

The estimated median overall survival was 47 months.

Median progression-free survival for all patients was 21 months.

In a historical comparison between this FCR trial and earlier FC trials the

study indicates:

The ORR was similar for patients treated with FCR versus FC.

Patients receiving FCR experienced longer PFS (FCR -21 months vs FC -11 months).

Overall survival (FCR-47 months vs FC-21 months).

As part of the conclusion the paper advises:

" We recommend this regimen be used with caution in patients older than the age

of 70, with assessment of comorbidity status, dose adjustments, and

consideration of growth factor support. "

PDF Link:http://bloodjournal.hematologylibrary.org/cgi/reprint/117/11/3016.pdf

~chris

CLL CANADA

http://cllcanada.ca