Re: VTE ? Blood clotting issues in CLL

[Guest guest]

I cannot speak to clotting issues in CLL. I have read and

been told that cancer in general creates a risk for blood

clots. There is a supplement that is a soy product that is

called Nattokinase. I know a number of people diagnosed

with different types of cancer who take this as a precaution.

Nattokinase may be contra-indicated in the case of CLL, but

there's no harm in finding out more about it, in general.

We are getting a call tomorrow morning from a doctor who

will answer some questions about it for us. I will ask him

about CLL. We are dealing with taking a drug that can cause

clotting, this is why we are looking into using it.

I am on this list because I am trying to help a friend

understand what he is dealing with a CLL diagnosis. Also,

I'm trying to help him add integrative medicine- but so far

I haven't seen anything.

grace

[Guest guest]

I have the opposite. When I was diagnosed in 2006 with CLL,

I was also diagnosed with Acquired von Willebrands Disease.

It's like hemophilia. I've been told it was acquired by the CLL.

[Guest guest]

Located this item on VTE ... just the abstract.

Leuk Res. 2011 Mar;35(3):419-21. Epub 2010 Dec 14.

Chronic lymphocytic leukaemia is a risk factor for venous thromboembolism.

Whittle AM, Allsup DJ, JR.

http://www.ncbi.nlm.nih.gov/pubmed/21156322

Department of Haematology, Queens Oncology Centre, Castle Hill Hospital,

Cottingham, East Yorkshire HU16 5JQ, UK.

Abstract

Venous thromboembolism (VTE) is a major cause of morbidity and mortality in

cancer patients. The literature is sparse on the incidence in the most common

lymphoid malignancy, chronic lymphocytic leukaemia (CLL). We calculated the

incidence rates for VTE in an unselected UK CLL clinic population at 1.45% per

patient year.

This represents a tenfold increase over previously published estimates of

incidence in the general population and a twofold increase over that of the

local hospital inpatient population. In our cohort, the risk of VTE was related

to stage C disease. Clinicians should be aware that CLL patients are at risk of

VTE.

Elsevier Ltd. All rights reserved.

PMID: 21156322

Karl

[Guest guest]

Karl

Thank you, I am sure many would like to be aware of this paper. I am pleased to

I see a document that firms up the belief that the risk of another event may

increase in CLL for me. As I would normaly be considered at a greater risk

because of my history, this information adds to my vigalence in reducing the

chance of other risk factors.

I currently have a saftey net of Symvistatin, Asprin, dipridamol and manage my

hypertension. The abstract states; " the risk of VTE was related to stage C

disease " . Which suggests a need remain vigalent as my disease progresses.

Part of the reason for my current exorcise is to narrow down any concern I have,

to allow me to express this in a relevant fashion during my next visit with my

CLL specialist. As hypertension is managed also, I don't know how treatment or

the disease may affect this, but will be keeping a watch full eye. Perhaps you

may be able to shed a little light for me on inflammation in CLL as this is a

cause factor, I wonder if Arthritis may also be a player?

Nick

>

> Located this item on VTE ... just the abstract.

>

> Leuk Res. 2011 Mar;35(3):419-21. Epub 2010 Dec 14.

>

> Chronic lymphocytic leukaemia is a risk factor for venous thromboembolism.

> Whittle AM, Allsup DJ, JR.

>

> http://www.ncbi.nlm.nih.gov/pubmed/21156322

[Guest guest]

Hi, You're welcome. I'm hardly an expert in this area. Here's a paper

providing background on the risk factors which includes therapy.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727713/

There's one theory that clotting could be an adaptation of the body to an

advanced cancer in order to slow down its spread. As you will see the

mechanisms of thrombosis are many and the interactions are very complex. So I

expect that timely and effective therapy of the cancer is most important VTE

preventive strategy.

Regarding reducing other risk factors, it certainly can't hurt to also work on

improving fitness and general health ...

All the best,

Karl

>

> Karl

>

> Thank you, I am sure many would like to be aware of this paper. I am pleased

to I see a document that firms up the belief that the risk of another event may

increase in CLL for me. As I would normaly be considered at a greater risk

because of my history, this information adds to my vigalence in reducing the

chance of other risk factors.

>

> I currently have a saftey net of Symvistatin, Asprin, dipridamol and manage my

hypertension. The abstract states; " the risk of VTE was related to stage C

disease " . Which suggests a need remain vigalent as my disease progresses.

>

> Part of the reason for my current exorcise is to narrow down any concern I

have, to allow me to express this in a relevant fashion during my next visit

with my CLL specialist. As hypertension is managed also, I don't know how

treatment or the disease may affect this, but will be keeping a watch full eye.

Perhaps you may be able to shed a little light for me on inflammation in CLL as

this is a cause factor, I wonder if Arthritis may also be a player?

>

> Nick