Re: CLL much different than we thought...

[Guest guest]

It carries on for me, my visit to London last week, to the UK CLL Forum's

Annual Scientific Day, conference " From bench to bedside " and outlines some of

the new research techniques I am learning about (of course I was well out of my

depth, but attended as a CLLSA delegate, witnessing events from a novice

patients point of view)All soon to be on their site following it's update, which

will give specialists and researchers greater access to pooled information.

This paper gave me a little insight into how connected CLL and inflammation are.

Raising the question again about the relationship of Arthritis and CLL.

Sampled from document

Antigen stimulation/inflammation and the natural history

of chronic lymphocytic leukemia

The relationship between

antigen stimulation/inflammation and the natural history

of CLL is not surprising considering that inflammation is

involved in the initiation and progression of several chronic

lymphoid malignancies of B-cell type.

Tissue events

(iii)proliferate in specific

niches, the pseudofollicular proliferation centers, which

are not detected in any other B-cell malignancy, but are

observed in inflamed tissues of patients with systemic

autoimmune/inflammatory disorders;

Novel perspectives

Understanding which genes are involved in the transition

of monoclonal B-cell lymphocytes into overt CLL

and investigating to what extent antigen stimulation

and an inflammatory proactive microenvironment

favor this transition may provide a clue to many unanswered

questions

I see now that Arthritus cure may not just be a benificial side effect of

treatment, but an important factor for consideration as part of treatment.

Monoclonal antibody treatments perhaps being the agent. Suggest that the

arthritus should be considered as part of the condition for treatment?

I know this overlaps with my post on VTE and inflamation issues, but it is very

current for me. Thankyou for the post.

Nick(UK)

>

> This is perspective article " Inflammation, the microenvironment and chronic

lymphocytic leukemia " by Federico Caligaris-Cappio

>

> Department of Oncology and Division of Molecular Oncology, San Raffaele

Scientific Institute and Università Vita-Salute San Raffaele, Milano, Italy.

>

> It explains how we are beginning to understand what CLL is and how it

works...based on the idea of cell proliferation in the nodes and spleen.

>

> " CLL cells circulating in the peripheral blood are the tip of the iceberg.

The most significant pathophysiological events occur in tissues where leukemic

cells are activated by exposure to antigens, although it is still unclear where

and how this exposure takes place. "

>

>

> Full PDF

> http://www.haematologica.org/cgi/reprint/96/3/353.pdf

>

> ~chris

> CLL CANADA

> http://cllcanada.ca

>